TOXICOLOGICAL SCIENCES

简称Toxicol Sci
大类医学
小类毒理学
ISSN1096-6080
EISSN1096-0929

最新文献

Late gestational exposure to flutamide alters stromal composition and immune landscape in the rat mammary gland during pre-puberty, peri-puberty, and adulthood

PMID: 421550372026-05-12

RNAseq analysis demonstrates polarization state-dependent responses to ambient particulate matter in a particle composition-specific manner

PMID: 420632262026-05-12

An environmentally relevant mixture of organophosphate esters induces cholesterol biosynthesis in THP-1 macrophages

PMID: 420153652026-05-12

Integration of mechanistic and repeat dose toxicity data in the derivation of an oral reference dose for HFPO-DA

PMID: 419680702026-05-12

Omeprazole activation of CD4+ and CD8+ T-cells through off-target covalent modification of cellular proteins

PMID: 420450072026-05-12

Integrating experimental data and mechanistic modeling to assess potential lead exposure from tampon use

PMID: 420973002026-05-07

High-concentration MEHP triggers mtDNA depletion in undifferentiated HepaRG and C2C12 cultures and disrupts mitochondrial homeostasis in both HepaRG culture states

PMID: 420546022026-04-28

Emergent latent neurotoxic effects of manganese following nominal chronic exposures in human stem cell and Caenorhabditis elegans models

PMID: 420337792026-04-07

Temporal variation in markers of immune signaling and wound repair in primary human airway epithelial cells following acute versus repeated woodsmoke condensate exposure

PMID: 418633942026-04-07

Integration of human microbiota (SIHUMIx) and zebrafish models reveals microbiome-mediated host responses to azoxystrobin

PMID: 417958362026-04-07

Quantitative estimates of inter-individual variability for new approach methodologies-based systemic safety toolbox using a population-based human in vitro model

PMID: 418831252026-04-07

An adverse outcome pathway-aligned ex vivo mouse testicular organ culture platform for mechanistic integration of multi-level endpoints with recovery assessment

PMID: 419032022026-04-07

Using fish models to understand the role of aryl hydrocarbon receptor (AHR)-interacting protein (AIP) in controlling sensitivity and resistance to dioxin-like compounds in vivo

PMID: 418407602026-03-16

Comparative investigation of the potential of glyphosate and glyphosate-based formulations (GBFs) to cause oxidative stress and DNA damage in human skin and liver cell systems

PMID: 418301632026-03-13

Expansion of preexisting cancer driver mutant clones is induced by the genotoxic carcinogen benzo[b]fluoranthene in MutaMouse lung

PMID: 418598122026-03-10

Short-term electrical stimulation promotes partial functional and morphological maturation of human-induced pluripotent stem cell-derived cardiomyocytes enabling cardiotoxicity risk mitigation at early-stage drug discovery for cardiac contractility modulation

PMID: 417127532026-03

Exposure of endothelial cells to doxorubicin inhibits extracellular matrix production by dermal fibroblasts in a paracrine manner

PMID: 417768282026-03

Removal of volatile organic compounds by chemical filters significantly inhibited the development of atopic dermatitis symptoms in mice: potential implications for air-conditioning systems in healthcare environments

PMID: 416782592026-03

Application of in vitro to in vivo extrapolation (IVIVE) to inform chemical health guidance value derivation-sample case studies comparing neuro-, hepato-, and developmental toxicities

PMID: 417036542026-03

Safetyome and specialized panels for over 3,000 phenotypes: a systematic and translational approach using human genetics and pharmacology

PMID: 417127612026-03