- 询价
- Cell Signaling Technology
- 3662
- USA
- 2026年05月28日
- W, IP, IHC-P, IF-IC, F
- Rabbit
- H,M,R,Mk,B,C,Dm
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- 文献和实验
- 技术资料
- 抗体英文名：
Acetyl-CoA Carboxylase Antibody
- 抗原：
synthetic peptide corresponding to residues surrounding Lys557 of human acetyl CoA carboxylase alpha1
- 应用范围：
W, IP, IHC-P, IF-IC, F
- 宿主：
Rabbit
- 库存：
大量
- 保质期：
详见说明书
- 供应商：
CST
- 级别：
详见MSDS文件
- 适应物种：
H,M,R,Mk,B,C,Dm
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation IHC-P=Immunohistochemistry (Paraffin) IF-IC=Immunofluorescence (Immunocytochemistry) F=Flow Cytometry
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey C=Chicken Dm=D. melanogaster B=Bovine
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP IHC-P IF-IC F | H M R Mk B (C) (Dm) | Endogenous | 280 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Acetyl CoA Carboxylase Antibody detects endogenous levels of all isoforms of acetyl CoA carboxylase protein. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys557 of human acetyl CoA carboxylase alpha1. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from 293, HeLa, A431, NIH/3T3, L929, C6, H-4-IIE and BAEC cells, using Acetyl CoA Carboxylase Antibody. IP
Immunprecipitation of Acetyl-CoA Carboxylase from AICAR treated C2C12 cell extracts using Acetyl CoA Carboxylase antibody (Lane 1). Lane 2: No antibody control. Lane 3: Input control. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human colon carcinoma, using Acetyl CoA Carboxylase Antibody in the presence of control peptide (left) or AcetylCoA Carboxylase Blocking Peptide #1062 (right). Flow Cytometry
Flow cytometric analysis of untreated HeLa cells, using Acetyl CoA Carboxylase Antibody (blue) compared to a nonspecific negative control antibody (red). IF-IC
Confocal microscopic images of A431 cells showing cytoplasmic stain with Acetyl CoA Carboxylase Antibody (A) compared to an isotype control (B). |
| Background | Acetyl-CoA carboxylase (ACC) catalyzes the carboxylation of acetyl-CoA to malonyl-CoA (1). It is the key enzyme in the biosynthesis and oxidation of fatty acids (1). In rodents, the 265 kDa ACC1 (ACCα) form is primarily expressed in lipogenic tissues, while the 280 kDa ACC2 (ACCβ) form is the main isoform in oxidative tissues (1,2). However, in humans, ACC2 is the predominant isoform in both lipogenic and oxidative tissues (1,2). Phosphorylation by AMPK at Ser79 or by PKA at Ser1200 inhibits the enzymatic activity of ACC (3). ACC is a potential target of anti-obesity drugs (4,5). |
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验The study of cellular function of a particular gene can be advanced by either specifically eliminating or blocking the function of its gene product. Although antisense RNA has frequently been used for this purpose, the hammerhead ribozyme
单酰 CoA＋ ADP 磷酸。
存在于线粒体中，是催化下列不可逆反应的酶。 EC6． 4． 1． 1．丙酮酸＋ CO2 ＋ ATP＋ H2 O→草酰乙酸＋ ADP＋ Pi，Δ Go ′＝ -0.5kcal．广泛存在于动物、霉菌和酵母中，但在植物体和大部分细菌中却不含此酶。在三羧酸循环中，它是供给草酰乙酸的主要补充反应。为一种变构酶，有乙酰 CoA时，其活性存在，同时含有生物素作为和 CO2 反应的酶的辅酶。分子量约 65万，有很多亚基。最适 pH为 4.8。
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