HMGA2 Antibody

HMGA2 Antibody

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  • 询价
  • Cell Signaling Technology已认证
  • USA
  • 2025年10月08日
  • W, IP
  • Rabbit
  • H,M,R
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    • 详细信息
    • 技术资料
    • 抗体英文名

      HMGA2 Antibody

    • 抗原

      synthetic peptide corresponding to residues near the amino-terminus of human HMGA2 protein

    • 应用范围

      W, IP

    • 宿主

      Rabbit

    • 适应物种

      H,M,R

    • 级别

      详见MSDS文件

    • 库存

      大量

    • 供应商

      CST

    • 保质期

      详见说明书

    • 是否单克隆

      2

    • 保存条件

      -20°c

    • 规格

      100 ul (10 western blots)/carrier free & custom formulation / quantity

    规格:产品价格:¥请询价
    规格:100 ul (10 western blots)产品价格:¥请询价
    规格:carrier free & custom formulation / quantity产品价格:¥请询价

    pathway more info application references datasheet PDF MSDS PDF protocols

    Applications Key:  W=Western Blotting  IP=Immunoprecipitation
    Reactivity Key:  H=Human  M=Mouse  R=Rat
    Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

    Applications Reactivity Sensitivity MW (kDa) Source
    W IP H M R Endogenous 18 Rabbit
    Protocols
    Specificity / Sensitivity

    HMGA2 Antibody detects endogenous levels of total HMGA2 protein.

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino-terminus of human HMGA2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Western Blotting

    Western Blotting

    Western blot analysis of extracts from various cell lines using HMGA2 Antibody.

    Background

    HMGA2 belongs to the family of high mobility group with AT-hook DNA binding domain. HMGA proteins are considered architectural transcription factors; they do not have direct transcriptional activation capacity, but instead regulate gene expression by changing DNA conformation through binding to AT-rich regions in the DNA and/or direct interaction with other transcription factors (1,2). HMGA2 is abundantly and ubiquitously expressed and plays a crucial role during embryonic development (3). HMGA2 promotes stem cell self-renewal and research studies have shown that decreased HMGA2 expression is associated with stem cell aging (4-7). Investigators have shown that expression levels of HMGA2 are very low in normal adult tissues, while either overexpression or rearrangement is associated with many types of cancer (8-11).

    1. Cleynen, I. and Van de Ven, W.J. (2008) Int J Oncol 32, 289-305.
    2. Pfannkuche, K. et al. (2009) Stem Cell Rev 5, 224-30.
    3. Monzen, K. et al. (2008) Nat Cell Biol 10, 567-74.
    4. Nishino, J. et al. (2008) Cell 135, 227-39.
    5. Li, O. et al. (2006) Genesis 44, 523-9.
    6. Li, O. et al. (2007) FEBS Lett 581, 3533-7.
    7. Pfannkuche, K. et al. (2009) Stem Cell Rev 5, 224-30.
    8. Fusco, A. and Fedele, M. (2007) Nat Rev Cancer 7, 899-910.
    9. Rawlinson, N.J. et al. (2008) Cancer Genet Cytogenet 181, 119-24.
    10. Wei, J.J. et al. (2010) Am J Surg Pathol 34, 18-26.
    11. Mahajan, A. et al. (2010) Mod Pathol 23, 673-81.
    Application References

    Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know !

    Companion Products

    For Research Use Only. Not For Use In Diagnostic Procedures.

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