Fatty Acid Synthase (C20G5) Ra

bbit mAb

价格询价

品牌Cell Signaling Technology
货号
3180
产地USA
更新日期2025年12月30日

应用范围W, IP, IHC-P, IHC-F, IF-IC
适应物种H,M,R,B

美国CST中国公司(丁香通商铺)

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详细信息
文献和实验
技术资料

抗体英文名：
Fatty Acid Synthase (C20G5) Rabbit mAb
抗原：
synthetic peptide around Gly46 corresponding to the sequence of human fatty acid synthase
应用范围：
W, IP, IHC-P, IHC-F, IF-IC
级别：
详见MSDS文件
供应商：
CST
适应物种：
H,M,R,B
库存：
大量
保质期：
详见说明书
是否单克隆：
0
保存条件：
-20°c
规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity

规格：		产品价格：	￥请询价
规格：	100 ul (10 western blots)	产品价格：	￥请询价
规格：	carrier free & custom formulation / quantity	产品价格：	￥请询价

pathway more info application references datasheet PDF MSDS PDF protocols

Applications Key: W=Western Blotting IP=Immunoprecipitation IHC-P=Immunohistochemistry (Paraffin) IHC-F=Immunohistochemistry (Frozen) IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key: H=Human M=Mouse R=Rat B=Bovine
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IHC-P IHC-F IF-IC	H M R (B)	Endogenous	273	Rabbit IgG

Protocols	3180: IHC / Frozen , IHC / Paraffin , IHC / Paraffin , Immunofluorescence , Immunoprecipitation , Western Blotting
Specificity / Sensitivity	Fatty Acid Synthase (C20G5) Rabbit mAb detects endogenous levels of total fatty acid synthase protein.
Source / Purification	Fatty Acid Synthase (C20G5) Rabbit mAb is produced by immunizing rabbits with a synthetic peptide around Gly46 corresponding to the sequence of human fatty acid synthase. Western Blotting Western blot analysis of extracts from various cell types using Fatty Acid Synthase (C20G5) Rabbit mAb. IHC-P (paraffin) Immunohistochemical analysis of paraffin-embedded breast carcinoma using Fatty Acid Synthase (C20G5) Rabbit mAb. IHC-P (paraffin) Immunohistochemical analysis of paraffin-embedded hepatocellular carcinoma using Fatty Acid Synthase (C20G5) Rabbit mAb. IHC-P (paraffin) Immunohistochemical analysis of paraffin-embedded lung carcinoma using Fatty Acid Synthase (C20G5) Rabbit mAb. IHC-P (paraffin) Immunohistochemical analysis of paraffin-embedded lymphoma, showing staining of adipocytes, using Fatty Acid Synthase (C20G5) Rabbit mAb. IHC-P (paraffin) Immunohistochemical analysis of paraffin-embedded mouse brown fat using Fatty Acid Synthase (C20G5) Rabbit mAb. IHC-F (frozen) Immunohistochemical analysis of frozen SKOV-3 xenograft using Fatty Acid Synthase (C20G5) Rabbit mAb. IF-IC Confocal immunofluorescent analysis of HeLa cells using Fatty Acid Synthase (C20G5) Rabbit mAb (green). Actin filaments have been labeled with DY-554 phalloidin (red). Blue pseudocolor = DRAQ5™ (fluorescent DNA dye).
Background	Fatty acid synthase (FASN) catalyzes the synthesis of long-chain fatty acids from acetyl-CoA and malonyl-CoA. FASN is active as a homodimer with seven different catalytic activities and produces lipids in the liver for export to metabolically active tissues or storage in adipose tissue. In most other human tissues, FASN is minimally expressed since they rely on circulating fatty acids for new structural lipid synthesis (1).Recently, increased expression of FASN has emerged as a phenotype common to most human carcinomas. In breast cancer, immunohistochemical staining showed that the levels of FASN are directly related to the size of breast tumors (2). Studies also showed that FASN is highly expressed in lung and prostate cancers and that FASN expression is an indicator of poor prognosis in breast and prostate cancer (3-5). Furthermore, inhibition of FASN is selectively cytotoxic to human cancer cells (5). Thus, increased interest has focused on FASN as a potential target for the diagnosis and treatment of cancer as well as metabolic syndrome (6,7). Katsurada, A. et al. (1990) Eur J Biochem 190, 427-33. Wells, W.A. et al. (2006) Breast Cancer Res Treat 98, 231-40. Kawamura, T. et al. (2005) Pathobiology 72, 233-240. Shah, U.S. et al. (2006) Hum Pathol 37, 401-409. Kuhajda, F.P. (2000) Nutrition 16, 202-8. Tian, W.X. (2006) Curr Med Chem 13, 967-977. Kusunoki, J. et al. (2006) Endocrine 29, 91-100.
Application References	Tiano, J.P. et al. (2011) J Clin Invest 121, 3331-42. Applications: Western Blotting Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know !
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