Phospho-Jak2 (Tyr1007/1008) An

tibody

价格询价

品牌Cell Signaling Technology
货号
3771
产地USA
更新日期2026年05月29日

应用范围W, IP
宿主Rabbit
适应物种H,M,R,B

美国CST中国公司(丁香通商铺)

品牌商

13 年钻石会员

详细信息
询价记录
文献和实验
技术资料

抗体英文名：
Phospho-Jak2 (Tyr1007/1008) Antibody
抗原：
synthetic phosphopeptide corresponding to residues surrounding Tyr1007/1008 of human Jak2 protein
应用范围：
W, IP
宿主：
Rabbit
供应商：
CST
保质期：
详见说明书
适应物种：
H,M,R,B
级别：
详见MSDS文件
库存：
大量
是否单克隆：
2
保存条件：
-20°c
规格：
100 ul (10 western blots)/300 ul (30 western blots)/carrier free & custom formulation / quantity

规格：		产品价格：	￥请询价
规格：	100 ul (10 western blots)	产品价格：	￥请询价
规格：	300 ul (30 western blots)	产品价格：	￥请询价
规格：	carrier free & custom formulation / quantity	产品价格：	￥请询价

pathway more info application references datasheet PDF MSDS PDF protocols

Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse R=Rat B=Bovine
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M (R) (B)	Endogenous	125	Rabbit

Protocols	3771: Immunoprecipitation , Western Blotting
Specificity / Sensitivity	Phospho-Jak2 (Tyr1007/1008) Antibody detects endogenous levels of Jak2 only when phosphorylated at Tyr1007/1008. This antibody may cross-react with phospho-Jak1 and phospho-Tyk2.
Source / Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1007/1008 of human Jak2 protein. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting Western blot analysis of extracts from UT7 cells, untreated or treated with GM-CSF (5 min), and BaF3 cells, untreated or treated with IL-3 (5 min), using Phospho-Jak2 (Tyr1007/1008) Antibody #3771 (upper) or total Jak2 (D2E12) XP^® Rabbit mAb #3230 (lower).
Background	Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors (1). Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats (2), Shc (3), insulin receptor substrates (4), and focal adhesion kinase (FAK) (5), typically contain SH2 or other phospho-tyrosine-binding domains. The tyrosine residues 1007/1008 of Jak2 in the putative activation loop are the homologous tyrosine residues 1054/1055 in Tyk2, which are important in the regulation of Tyk2 kinase activity (6). Leonard, W.J. and O'Shea, J.J. (1998) Annu Rev Immunol 16, 293-322. Darnell, J.E. (1997) Science 277, 1630-5. VanderKuur, J. et al. (1995) J Biol Chem 270, 7587-93. Argetsinger, L.S. et al. (1995) J Biol Chem 270, 14685-92. Zhu, T. et al. (1998) J Biol Chem 273, 10682-9. Gauzzi, M.C. et al. (1996) J. Biol. Chem. 271, 20494-20500.
Application References	Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know !
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