- 询价
- Cell Signaling Technology
- 4661
- USA
- 2026年05月28日
- W
- H,M,R,Mk
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- 文献和实验
- 技术资料
- 抗体英文名：
VDAC (D73D12) Rabbit mAb
- 抗原：
synthetic peptide corresponding to the amino terminus of human VDAC-1 protein
- 应用范围：
W
- 级别：
详见MSDS文件
- 保质期：
详见说明书
- 库存：
大量
- 供应商：
CST
- 适应物种：
H,M,R,Mk
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W | H M R Mk | Endogenous | 32 | Rabbit IgG |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | VDAC (D73D12) Rabbit mAb detects endogenous levels of total VDAC protein. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the amino terminus of human VDAC-1 protein. Western Blotting
Western blot analysis of extracts from various cell types using VDAC (D73D12) Rabbit mAb. |
| Background | Voltage-dependent anion channel (VDAC), ubiquitously expressed and located in the outer mitochondrial membrane, is generally thought to be the primary means by which metabolites diffuse in and out of the mitochondria (1). In addition, this channel plays a role in apoptotic signaling. The change in mitochondrial permeability characteristic of apoptosis is mediated by Bcl-2 family proteins, which bind to VDAC, altering the channel kinetics (2). Homodimerization of VDAC may be a mechanism for changing mitochondrial permeability and supporting release of cytochrome c (3). In mammalian cells, there are three VDAC isoforms, VDAC1, which is the most widely expressed isoform, as well as VDAC2 and VDAC3 (4,5). |
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验组织化学分析。（图 C）使用Anti-Erk1/2 Mouse mAb 鼠单抗进行目的蛋白检测；(图 D) 使用p44/42 MAPK （Erk1/2）Rabbit mAb 兔单抗进行目的蛋白检测。 图 7 免疫组化实验检测Akt表达 注：使用 Anti-Akt (pan) Rabbit mAb 对正常小鼠肝组织进行免疫组织化学分析。（图 E）使用免疫组化试剂盒 M&R HRP/DAB Detection IHC Kit，抗体1:100 稀释；(图F)使用另一种试剂盒，抗体 1:100 稀释。
、MAMs 的生理功能。MAMs 介导 Ca²⁺稳态（A）、脂质代谢合成与运输（B）、线粒体动力学（C）、内质网应激（D）、细胞凋亡（E）、自噬（F）、铁死亡（G）以及线粒体分裂因子（Mff）炎症（H）。 1、Ca²⁺稳态：MAMs通过IP3R‒GRP75‒VDAC1复合体把ER储存的Ca²⁺精准地送进线粒体，既给线粒体提供代谢信号，又防止胞质Ca²⁺过高；当细胞需求变化时，SERCA还能把线粒体多余的Ca²⁺泵回ER，形成动态循环，这种双向调控维持了整个细胞的钙稳态。 2、 脂质合成与转运：ER
Recombinant Rabbit mAb (Pacific blue Conjugate) (S-711-23) S0B6924 G4S Linker Recombinant Rabbit mAb (APC Conjugate) (S-5030) 65686 CAR (Whitlow/218 Linker) Cell Enrichment Kit 57710 Whitlow/218 Linker (E3U7Q) Rabbit Monoclonal Antibody 32523 Whitlow
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