VDAC (D73D12) Rabbit mAb产品图

VDAC (D73D12) Rabbit mAb

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  • 询价
  • Cell Signaling Technology已认证
  • USA
  • 2026年05月28日
  • W
  • H,M,R,Mk
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 抗体英文名:

      VDAC (D73D12) Rabbit mAb

    • 抗原:

      synthetic peptide corresponding to the amino terminus of human VDAC-1 protein

    • 应用范围:

      W

    • 级别:

      详见MSDS文件

    • 保质期:

      详见说明书

    • 库存:

      大量

    • 供应商:

      CST

    • 适应物种:

      H,M,R,Mk

    • 是否单克隆:

      1

    • 保存条件:

      -20°c

    • 规格:

      100 ul (10 western blots)/carrier free & custom formulation / quantity

    规格:产品价格:¥请询价
    规格:100 ul (10 western blots)产品价格:¥请询价
    规格:carrier free & custom formulation / quantity产品价格:¥请询价

    pathway more info application references datasheet PDF MSDS PDF protocols

    Applications Key:  W=Western Blotting
    Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Monkey
    Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

    Applications Reactivity Sensitivity MW (kDa) Isotype
    W H M R Mk Endogenous 32 Rabbit IgG
    Protocols
    Specificity / Sensitivity

    VDAC (D73D12) Rabbit mAb detects endogenous levels of total VDAC protein.

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the amino terminus of human VDAC-1 protein.

    Western Blotting

    Western Blotting

    Western blot analysis of extracts from various cell types using VDAC (D73D12) Rabbit mAb.

    Background

    Voltage-dependent anion channel (VDAC), ubiquitously expressed and located in the outer mitochondrial membrane, is generally thought to be the primary means by which metabolites diffuse in and out of the mitochondria (1). In addition, this channel plays a role in apoptotic signaling. The change in mitochondrial permeability characteristic of apoptosis is mediated by Bcl-2 family proteins, which bind to VDAC, altering the channel kinetics (2). Homodimerization of VDAC may be a mechanism for changing mitochondrial permeability and supporting release of cytochrome c (3). In mammalian cells, there are three VDAC isoforms, VDAC1, which is the most widely expressed isoform, as well as VDAC2 and VDAC3 (4,5).

    1. Hodge, T. and Colombini, M. (1997) J Membr Biol 157, 271-9.
    2. Shimizu, S. et al. (1999) Nature 399, 483-7.
    3. Zheng, Y. et al. (2004) Oncogene 23, 1239-47.
    4. Craigen, W.J. and Graham, B.H. (2008) J Bioenerg Biomembr 40, 207-12.
    5. Yamamoto, T. et al. (2006) J Proteome Res 5, 3336-44.
    Application References

    Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know !

    Companion Products

    For Research Use Only. Not For Use In Diagnostic Procedures.

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