- 询价
- Cell Signaling Technology
- 3331
- USA
- 2025年07月16日
- W
- Rabbit
- H,M,R,B
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- 详细信息
- 技术资料
- 抗体英文名：
Phospho-Jak1 (Tyr1022/1023) Antibody
- 抗原：
synthetic phosphopeptide corresponding to residues surrounding Tyr1022/1023 of human Jak1
- 应用范围：
W
- 宿主：
Rabbit
- 级别：
详见MSDS文件
- 供应商：
CST
- 库存：
大量
- 适应物种：
H,M,R,B
- 保质期：
详见说明书
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat B=Bovine
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H M (R) (B) | Endogenous | 130 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Phospho-Jak1 (Tyr1022/1023) Antibody detects endogenous levels of Jak1 only when phosphorylated at tyrosines 1022/1023. This antibody may cross-react with phospho-Jak2. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1022/1023 of human Jak1. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from HT-29 cells treated with IL-4 (100 ng/ml) for the indicated times, using Phospho-Jak1 (Tyr1022/1023) Antibody (upper) or Jak1 Antibody (lower). |
| Background | Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors (1). Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats (2), Shc (3), insulin receptor substrates (4), and focal adhesion kinase (FAK) (5), typically contain SH2 or other phospho-tyrosine-binding domains. The tyrosine residues 1022/1023 of Jak1 in the putative activation loop are the homologous tyrosine residues 1054/1055 in Tyk2, which are important in the regulation of Tyk2 kinase activity (6).(This product is sold under license from Chemicon, Inc., U.S. Patent No. 5,658,791.)
|
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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