- 询价
- Cell Signaling Technology
- 3670
- USA
- 2025年09月26日
- western blot,免疫组化（IHC）,免疫荧光（IF）
- 小鼠
- 人,小鼠,大鼠
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- 详细信息
- 询价记录
- 技术资料
- 抗体英文名：
GFAP (GA5) Mouse mAb
- 是否单克隆：
1
- 抗原来源：
/
- 保质期：
详见说明书
- 宿主：
小鼠
- 级别：
详见MSDS文件
- 库存：
大量
- 适应物种：
人,小鼠,大鼠
- 应用范围：
western blot,免疫组化（IHC）,免疫荧光（IF）
- 保存条件：
-20°c
- 供应商：
CST
- 抗原：
/
- 规格：
40 ul (4 western blots)/100 ul (10 western blots)/<a href="http://www.cellsignal.com/ddt/custom_reagents.html" target="_blank">carrier free & custom formulation / quantity</a> /40 ul (4 western blots)/100 ul (10 western blots)/<a href="http://www.cellsignal.com/ddt/custom_reagents.html" target="_blank">carrier free & custom formulation / quantity</a>
| 规格： | 产品价格： | ￥面议 | |
|---|---|---|---|
| 规格： | 40 ul (4 western blots) | 产品价格： | ￥请询价 |
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | <a href="http://www.cellsignal.com/ddt/custom_reagents.html" target="_blank">carrier free & custom formulation / quantity</a> | 产品价格： | ￥请询价 |
| 规格： | 40 ul (4 western blots) | 产品价格： | ￥请询价 |
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | <a href="http://www.cellsignal.com/ddt/custom_reagents.html" target="_blank">carrier free & custom formulation / quantity</a> | 产品价格： | ￥请询价 |
Product Pathways - Neuroscience
GFAP (GA5) Mouse mAb #3670
PhosphoSitePlus ® protein, site, and accession data: GFAP
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W IHC-P IF-F | H M R | Endogenous | 50 | Mouse IgG1 |
Applications Key: W=Western Blotting IHC-P=Immunohistochemistry (Paraffin) IF-F=Immunofluorescence (Frozen)
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Protocols
Specificity / Sensitivity
GFAP (GA5) Mouse mAb detects endogenous levels of total GFAP protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with native GFAP purified from pig spinal cord.
Western Blotting
Western blot analysis of extracts from mouse and rat brain, using GFAP (GA5) Mouse mAb.
IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human medulloblastoma, using GFAP (GA5) Mouse mAb.
IF-F
Confocal immunofluorescence image of rat hippocampus labeled with GFAP (GA5) Mouse mAb (red), Phospho-S6 Ribosomal Protein (Ser235/236) (2F9) Rabbit mAb (Alexa Fluor® 488 Conjugate) #4854 (green), and CREB (48H2) Rabbit mAb #9197 (blue).
Background
The cytoskeleton consists of three types of cytosolic fibers: microfilaments (actin filaments), intermediate filaments, and microtubules. Major types of intermediate filaments are specifically expressed in particular cell types: cytokeratins in epithelial cells, glial fibrillary acidic protein (GFAP) in glial cells, desmin in skeletal, visceral, and certain vascular smooth muscle cells, vimentin in cells of mesenchymal origin, and neurofilaments in neurons. GFAP and vimentin form intermediate filaments in astroglial cells and modulate their motility and shape (1). In particular, vimentin filaments are present at early developmental stages, while GFAP filaments are characteristic of differentiated and mature brain astrocytes. Thus, GFAP is commonly used as a marker for intracranial and intraspinal tumors arising from astrocytes (2). In addition, GFAP intermediate filaments are also present in non-myelin-forming Schwann cells in the peripheral nervous system (3).
- Eng, L.F. et al. (2000) Neurochem. Res. 25, 1439-51.
- Goebel, H.H. et al. (1987) Acta. Histochem. Suppl. 34, 81-93.
- Jessen, K.R. et al. (1990) Development 109, 91-103.
Application References
- Davies, J.E. et al. (2008) J Biol 7, 24. Applications: IF-IC (In Cells)
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know !
Companion Products
- 2148 α/β-Tubulin Antibody
- 7072 Phototope® -HRP Western Blot Detection System, Anti-mouse IgG, HRP-linked Antibody
- 7076 Anti-mouse IgG, HRP-linked Antibody
- 7720 Prestained Protein Marker, Broad Range (Premixed Format)
- 7727 Biotinylated Protein Ladder Detection Pack
- 7003 20X LumiGLO® Reagent and 20X Peroxide
- 8112 SignalStain® Antibody Diluent
For Research Use Only. Not For Use In Diagnostic Procedures.
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