- 询价
- Cell Signaling Technology
- 4394
- USA
- 2026年05月29日
- W, IP
- H,M,R,Mk
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- 文献和实验
- 技术资料
- 抗体英文名：
β-TrCP (D13F10) Rabbit mAb
- 抗原：
synthetic peptide corresponding to residues surrounding Ile69 of human β-TrCP protein
- 应用范围：
W, IP
- 库存：
大量
- 适应物种：
H,M,R,Mk
- 级别：
详见MSDS文件
- 保质期：
详见说明书
- 供应商：
CST
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W IP | H M R Mk | Endogenous | 62 | Rabbit IgG |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | β-TrCP (D13F10) Rabbit mAb detects endogenous levels of total β-TrCP protein. The antibody also recognizes a 40 kDa band of unknown origin. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ile69 of human β-TrCP protein. Western Blotting
Western blot analysis of extracts from various cell lines using β-TrCP (D13F10) Rabbit mAb. |
| Background | β-transducin repeat-containing protein (β-TrCP or FBW1A) is an F-box family protein characterized by the presence of the protein-protein mediating F-box domain first described in cyclin F. F box proteins act as substrate adapters that target proteins containing a specific phosphorylated sequence element, referred to as a phosphodegron, to the SCF E3 ubiquitin ligase complex for ubiquitination (1,2). β-TrCP targets many important proteins with diverse functions, such as p53, H-Ras, Smad4, IκBα, β-catenin and the cell cycle checkpoint protein claspin, for ubiquitin-mediated degradation (3-5). Inhibition of β-TrCP expression has a demonstrated benefit in the treatment of prostate cancer (6).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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