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文献和实验Targeting Tumor Vasculature Using VEGF-Toxin Conjugates
, matrix degradation, endothelial cell migration and tube formation. Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), is an important angiogenic mediator secreted by tumor cells (2 ). VEGF binds to receptor
PriCells: Primary cells culture with supplement of vascular endothelial growth factor (VEGF)
Over-expression of VEGF can cause vascular disease in the retina of the eye and other parts of the body. Drugs such as bevacizumab can inhibit VEGF and control or slow those diseases. VEGF is a sub-family of growth factors, to be specific, the platelet-derived
factor in vivo. Two high-affinity tyrosine kinase receptors for VEGF121 have been identified, VEGFR-1 (FLT -1), and VEGFR-2 (KDR). consistent with the endothelial cell-specific action of VEGF121, expression of both receptor genes
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