p38 MAPK 多克隆抗体 14064-1-AP产品图
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p38 MAPK 多克隆抗体 14064-1-AP

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  • ¥1350 - 3000
  • Proteintech已认证
  • 14064-1-AP
  • 2025年10月13日
  • WB, IHC, ELISA
  • Rabbit
  • human, mouse, rat
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    • 详细信息
    • 询价记录
    • 文献和实验
    • 技术资料
    • 免疫原:

      Recombinant human p38 MAPK protein

    • 亚型:

      IgG

    • 保存条件:

      Store at -20°C. Stable for one year after shipment.

    • 克隆性:

      Polyclonal

    • 标记物:

      Unconjugated

    • 适应物种:

      human, mouse, rat

    • 保质期:

      详见产品包装

    • 库存:

      充足

    • 宿主:

      Rabbit

    • 应用范围:

      WB, IHC, ELISA

    • 靶点:

      p38 MAPK

    • 抗体英文名:

      p38 MAPK Polyclonal antibody

    • 抗体名:

      p38 MAPK Polyclonal antibody

    • 规格:

      50ul/100ul/150ul

    规格:50ul产品价格:¥1350.0
    规格:100ul产品价格:¥2200.0
    规格:150ul产品价格:¥3000.0

    经过测试的应用

    Positive WB detected inHeLa cells, mouse heart tissue, Jurkat cells, RAW 264.7 cells, Neuro-2a cells, NIH/3T3 cells, rat spleen tissue, rat heart tissue, K-562 cells
    Positive IHC detected inhuman colon cancer tissue, human liver cancer tissue
    Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
    Planning an IHC experiment? We recommend our IHCeasy p38 MAPK Ready-To-Use IHC Kit. p38 MAPK primary antibody included.

    推荐稀释比

    应用推荐稀释比
    Western Blot (WB)WB : 1:2000-1:12000
    Immunohistochemistry (IHC)IHC : 1:200-1:800
    It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
    Sample-dependent, Check data in validation data gallery.

    产品信息

    14064-1-AP targets p38 MAPK in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

    经测试应用 WB, IHC, ELISA
    文献引用应用WB, IHC, IF
    经测试反应性 human, mouse, rat
    文献引用反应性human, mouse, rat, pig, rabbit, chicken, zebrafish, goat, fish, duck
    免疫原

    CatNo: Ag5115

    Product name: Recombinant human p38 MAPK protein

    Source: e coli.-derived, PGEX-4T

    Tag: GST

    Domain: 1-307 aa of BC031574

    Sequence: MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY

    宿主/亚型 Rabbit / IgG
    抗体类别 Polyclonal
    产品类型 Antibody
    全称 mitogen-activated protein kinase 14
    别名 MAPK14, Cytokine suppressive anti-inflammatory drug-binding protein, CSPB1, CSBP2, CSBP1
    计算分子量 360 aa, 41 kDa
    观测分子量 38-42 kDa
    GenBank蛋白编号BC031574
    基因名称 p38 MAPK
    Gene ID (NCBI) 1432
    RRIDAB_2878007
    偶联类型 Unconjugated
    形式Liquid
    纯化方式Antigen affinity purification
    UNIPROT IDQ16539
    储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
    储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

    背景介绍

    MAPK14(mitogen-activated protein kinase 14) is also named as SAPK2A, p38MAPK, CSBP1, RK, p38, EXIP, Mxi2, CSBP2, PRKM14, PRKM15, CSPB1, p38ALPHA and belongs to the MAP kinase subfamily. MAPK14-signaling is a central pathway for the integration of instructive signals in dendritic cells for T(H)17 differentiation and inflammation(PMID:22231518). It plays an important role in the regulation of hematopoietic stem cellself-renewal in vitro and inhibition of MAPK14 activation with a small molecule inhibitor may represent a novel approach to promote ex vivo expansion of hematopoietic stem cell(PMID:21198398). This protein has some isoforms with MW 29-31 kDa, 35 kDa and 41 kDa.

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    图标询价记录
    图标暂无询价记录
    图标文献和实验
    该产品被引用文献
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    [3]STING deficiency alleviates scar formation after glaucoma filtration surgery by suppressing p38 MAPK-induced inflammation in mice.
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    [4]CpG ODN Activates TLR9 and Upregulates TLR3 via the p38 MAPK-ATF3 Signaling Axis to Synergistically Enhance Dendritic Cell Vaccine Efficacy.
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    [5]Desulfovibrio vulgaris exacerbates sepsis by inducing inflammation and oxidative stress in multiple organs.
    PMID:40371102Front Microbiol2025-04-30
    [6]HSPA1A inhibits pyroptosis and neuroinflammation after spinal cord injury via DUSP1 inhibition of the MAPK signaling pathway.
    PMID:39924492Mol Med2025-02-09
    [7]Ferrostatin-1 inhibits osteoclast differentiation and prevents osteoporosis by suppressing lipid peroxidation.
    PMID:39885539J Orthop Surg Res2025-01-30
    [8]Erianin inhibits the progression of pancreatic cancer by directly targeting AKT and ASK1.
    PMID:39456094Cancer Cell Int2024-10-25
    [9]Corilagin relieves atherosclerosis via the toll-like receptor 4 signaling pathway in vascular smooth muscle cells.
    PMID:38869980Int J Immunopathol Pharmacol2024-01
    [10]The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.
    PMID:34814904BMC Endocr Disord2021-11-23
    相关实验
    • 检测RAS、MAPK、p38、p21

      【求助】请问如何检测RAS、MAPK、p38、p21 ?参与者:liqunfeng请问如何检测RAS、MAPK、p38、p21??谁帮帮我啊参与者:xiaolx你在网上搜搜别人的实验中怎么检测的,不就知道了。p38,我师姐做过免疫组化。参与者:zhangyuelin1999检测信号通路现在用的比较多的方法应该是Western blot,它是测细胞中的蛋白含量(半定量)的最好方法了,免疫组化检测是定性的!如果时间充裕的话,你可以两种方法都可以做的。RAS:Ras蛋白是细胞内的一种小分子GTP结合

    • 【求助】请教关于AP-1一抗的选择

      ampk细胞通路是通过磷酸化激活下游的,磷酸化的就是活化形式啦,比如c-jun吧,有钱的话还是要要买c-jun和p-c-jun的,紧张的话但用p-c-jun也能说明问题,里面的各型无非就是多抗,兔或鼠单抗,兔单抗比较好,选择的话还要看你做什么用途,个人浅见 ampk? 还是mapk?  如果是AMPK的话, 那么离AP-1还很远, 最起码中间还隔着MAPK. :D:D 如果LZ想看表达的话不买Total c-jun

    • 【求助】MAPK通路抑制的问题

      yy59410 在下在做MAPK通路对皮肤成纤维细胞凋亡诱导的作用,我分别用p38,JNK,ERK相应的通路抑制剂阻断相应的通路后看给药后细胞的情况,发现这些通路的阻断并不能阻断药物对细胞的凋亡诱导,想请教坛子里的高手们这是怎么回事?我接下来需要做什么? 希望大侠们赐教。不甚感激啊。 chuckdouble yy59410 wrote: 在下在做MAPK通路对皮肤成纤维

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    ¥1350 - 3000