Snail (C15D3) Rabbit mAb产品图

Snail (C15D3) Rabbit mAb

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  • 询价
  • Cell Signaling Technology已认证
  • USA
  • 2026年05月29日
  • W, IP
  • H,M,R,Mk
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    • 详细信息
    • 询价记录
    • 文献和实验
    • 技术资料
    • 抗体英文名:

      Snail (C15D3) Rabbit mAb

    • 抗原:

      recombinant human Snail protein

    • 应用范围:

      W, IP

    • 级别:

      详见MSDS文件

    • 供应商:

      CST

    • 保质期:

      详见说明书

    • 适应物种:

      H,M,R,Mk

    • 库存:

      大量

    • 是否单克隆:

      1

    • 保存条件:

      -20°c

    • 规格:

      40 ul (4 western blots)/100 ul (10 western blots)/carrier free & custom formulation / quantity

    规格:产品价格:¥请询价
    规格:40 ul (4 western blots)产品价格:¥请询价
    规格:100 ul (10 western blots)产品价格:¥请询价
    规格:carrier free & custom formulation / quantity产品价格:¥请询价

    pathway more info application references datasheet PDF MSDS PDF protocols

    Applications Key:  W=Western Blotting  IP=Immunoprecipitation
    Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Monkey
    Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

    Applications Reactivity Sensitivity MW (kDa) Isotype
    W IP H M R Mk Endogenous 29 Rabbit IgG
    Protocols
    Specificity / Sensitivity

    Snail (C15D3) Rabbit mAb detects endogenous levels of total Snail protein.

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a recombinant human Snail protein.

    Western Blotting

    Western Blotting

    Western blot analysis of extracts from various cell lines using Snail (C15D3) Rabbit mAb.

    Background

    Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells (1-3). Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines (4,5). In addition, Snail blocks the cell cycle and confers resistance to cell death (6). Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function (7-10).

    1. Barrallo-Gimeno, A. and Nieto, M.A. (2005) Development 132, 3151-3161.
    2. Cano, A. et al. (2000) Nat. Cell Biol. 2, 76-83.
    3. Batlle, E. et al. (2000) Nat. Cell Biol. 2, 84-89.
    4. Yokoyama, K. et al. (2003) Int. J. Oncol. 22, 891-898.
    5. Yokoyama, K. et al. (2001) Oral Oncol. 37, 65-71.
    6. Vega, S. et al. (2004) Genes Dev. 18, 1131-1143.
    7. Zhou, B.P. et al. (2004) Nat. Cell Biol. 6, 931-940.
    8. Bachelder, R.E. et al. (2005) J. Cell Biol. 168, 29-33.
    9. Yook, J.I. et al. (2005) J. Biol. Chem. 280, 11740-11748.
    10. Yang, Z. et al. (2005) Cancer Res. 65, 3179-3184.
    Application References

    Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know !

    Companion Products

    For Research Use Only. Not For Use In Diagnostic Procedures.

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    图标文献和实验
    该产品被引用文献
    [1]GLIS2 Promotes Epithelial-Mesenchymal Transition and Gastric Cancer Progression by Regulating BGN to Activate the Wnt/β-Catenin Pathway.
    PMID:40936440Kaohsiung J Med Sci2026-02
    [2]Developing a prognostic stratification model based on glutathione metabolism in thyroid cancer and validating RRM2's tumor-promoting role.
    PMID:41333212Front Oncol2025-11-17
    [3]A CEBPB/TYMP/GDF15 signaling axis mediates tumor growth and cisplatin resistance in bladder cancer.
    PMID:40957398Transl Oncol2025-11
    [4]Development of ZHPV16E7- granzyme B immunoaffitoxin: dual mechanisms targeting hpv16-positive cervical cancer through epithelial-mesenchymal transition inhibition and cell death.
    PMID:40761801Front Immunol2025-07-21
    [5]CYMP-AS1 Promotes Ovarian Cancer Progression by Enhancing the Intracellular Translocation of hnRNPM and Reducing the Stability of AXIN2 mRNA.
    PMID:40746892Oncol Res2025-07-18
    [6]CD151 Promotes Cancer Progression in Triple-Negative Breast Cancer by Inducing EMT through the MAPK Signaling Pathway.
    PMID:40458675Breast Cancer (Dove Med Press)2025-05-28
    [7]RAB26 promotes prostate cancer progression via the MAPK/ERK-TWIST1 signaling axis.
    PMID:40821113Genes Dis2025-05-22
    [8]Circular RNA circHSPA8 Aggravates Metastasis by Acting as a Competitive Inhibitor of miR-195-5p to Upregulate WNT3A Expression in Breast Cancer.
    PMID:40099939J Cell Mol Med2025-03
    [9]Aspartate β-hydroxylase Regulates Expression of Ly6 Genes.
    PMID:38356711J Cancer2024-01-01
    [10]A Novel Isotope-labeled Small Molecule Probe CC12 for Anti-glioma via Suppressing LYN-mediated Progression and Activating Apoptosis Pathways.
    PMID:37416766Int J Biol Sci2023-06-19
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