IκBα (44D4) Rabbit mAb产品图

IκBα (44D4) Rabbit mAb

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  • 询价
  • Cell Signaling Technology已认证
  • USA
  • 2026年05月28日
  • W, IP
  • H,M,R,Hm,Mk,Mi
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    • 详细信息
    • 询价记录
    • 文献和实验
    • 技术资料
    • 抗体英文名

      IκBα (44D4) Rabbit mAb

    • 抗原

      synthetic peptide corresponding to residues near the carboxy-terminus of human IκBα

    • 应用范围

      W, IP

    • 供应商

      CST

    • 级别

      详见MSDS文件

    • 保质期

      详见说明书

    • 适应物种

      H,M,R,Hm,Mk,Mi

    • 库存

      大量

    • 是否单克隆

      1

    • 保存条件

      -20°c

    • 规格

      100 ul (10 western blots)/carrier free & custom formulation / quantity

    规格:产品价格:¥请询价
    规格:100 ul (10 western blots)产品价格:¥请询价
    规格:carrier free & custom formulation / quantity产品价格:¥请询价

    pathway more info application references datasheet PDF MSDS PDF protocols

    Applications Key:  W=Western Blotting  IP=Immunoprecipitation
    Reactivity Key:  H=Human  M=Mouse  R=Rat  Hm=Hamster  Mk=Monkey  Mi=Mink
    Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

    Applications Reactivity Sensitivity MW (kDa) Isotype
    W IP H M R Hm Mk Mi Endogenous 39 Rabbit IgG
    Protocols
    Specificity / Sensitivity

    IκBα (44D4) Rabbit mAb detects endogenous levels of total IκBα protein.

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy-terminus of human IκBα.

    Western Blotting

    Western Blotting

    Western blot analysis of extracts from HeLa, NIH/3T3 and PC12 cells, using IκBα (44D4) Rabbit mAb.

    Background

    The NF-κB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins (1-3). Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-κB (3-7). IκBα phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IκB at these activating sites have been identified (8).

    1. Baeuerle, P.A. and Baltimore, D. (1988) Science 242, 540-6.
    2. Beg, A.A. and Baldwin, A.S. (1993) Genes Dev 7, 2064-70.
    3. Finco, T.S. et al. (1994) Proc Natl Acad Sci USA 91, 11884-8.
    4. Brown, K. et al. (1995) Science 267, 1485-8.
    5. Brockman, J.A. et al. (1995) Mol Cell Biol 15, 2809-18.
    6. Traenckner, E.B. et al. (1995) EMBO J 14, 2876-83.
    7. Chen, Z.J. et al. (1996) Cell 84, 853-62.
    8. Karin, M. and Ben-Neriah, Y. (2000) Annu Rev Immunol 18, 621-63.
    Application References

    Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know !

    Companion Products

    Rabbit Monoclonals Produced Using Epitomics® Technology, U.S. Patent No. 5,675,063.


    For Research Use Only. Not For Use In Diagnostic Procedures.

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    • 作者
    • 内容
    • 询问日期
    图标文献和实验
    该产品被引用文献
    [1]Eupatorium lindleyanum DC. Suppresses Cytokine Storm by Inhibiting NF-κB and PI3K-Akt Signaling in Sepsis-Associated and Virus-Related Acute Lung Injury.
    PMID:41899484Curr Issues Mol Biol2026-03-21
    [2]TRIM14 Inhibition Suppresses Microglial Polarization and Pyroptosis Through the NF-κB/NLRP3 Pathway to Enhance Spinal Cord Injury Repair.
    PMID:41250673Mediators Inflamm2025-11-09
    [3]Multi-Omics and Experimental Insights into the Protective Effects of Sesquiterpenoid Lactones from Eupatorium lindleyanum DC. in Acute Lung Injury: Regulation of PI3K-Akt and MAPK-NF-κB Pathways.
    PMID:41155638Pharmaceuticals (Basel)2025-10-10
    [4]Ginsenoside Rg5 modulates the TLR4 and BCL-2 pathways by inhibiting NOX1, thereby alleviating inflammation, apoptosis and pyroptosis in hyperuricemia nephropathy.
    PMID:40621077J Ginseng Res2025-07
    [5]Elemene as a binding stabilizer of microRNA-145-5p suppresses the growth of non-small cell lung cancer.
    PMID:40161444J Pharm Anal2025-03
    [6]High mortality of Acinetobacter baumannii infection is attributed to macrophage-mediated induction of cytokine storm but preventable by naproxen.
    PMID:39303669EBioMedicine2024-10
    [7]The cytochrome P4501A1 (CYP1A1) inhibitor bergamottin enhances host tolerance to multidrug-resistant Vibrio vulnificus infection.
    PMID:38981821Chin J Traumatol2024-09
    [8]Macrophage-specific FGFR1 deletion alleviates high-fat-diet-induced liver inflammation by inhibiting the MAPKs/TNF pathways.
    PMID:38279043Acta Pharmacol Sin2024-05
    [9]BAP31 Promotes Adhesion Between Endothelial Cells and Macrophages Through the NF-κB Signaling Pathway in Sepsis.
    PMID:38434584J Inflamm Res2024-02-26
    [10]USP10 is a potential mediator for vagus nerve stimulation to alleviate neuroinflammation in ischaemic stroke by inhibiting NF-κB signalling pathway.
    PMID:37153558Front Immunol2023-04-14
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