- 询价
- Cell Signaling Technology
- 3629
- USA
- 2026年05月29日
- W, IP
- H,M,R,Mk
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- 文献和实验
- 技术资料
- 抗体英文名：
Integrin beta-5 (D24A5) Rabbit mAb
- 抗原：
synthetic peptide corresponding to residues surrounding Lys789 of human integrin beta-5 protein
- 应用范围：
W, IP
- 库存：
大量
- 保质期：
详见说明书
- 级别：
详见MSDS文件
- 适应物种：
H,M,R,Mk
- 供应商：
CST
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W IP | H M R Mk | Endogenous | 90 | Rabbit IgG |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Integrin beta-5 (D24A5) Rabbit mAb detects endogenous levels of total integrin beta-5 protein. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys789 of human integrin beta-5 protein. 
Western blot analysis of extracts from various cell lines using Integrin beta-5 (D24A5) Rabbit mAb. |
| Background | Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins having distinct tissue distribution and overlapping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with extracellular environment (inside-out signaling) (1,2).The αVβ5 integrin is expressed in various tissues and cell types, including endothelia, epithelia and fibroblasts (4). It plays a role in matrix adhesion to VN, FN, SPARC and bone sialoprotein (5) and functions in the invasion of gliomas and metastatic carcinoma cells (6,7). αVβ5 integrin plays a major role in growth-factor-induced tumor angiogenesis, where cooperative signaling by the αVβ5 integrin and growth factors regulates endothelial cell proliferation and survival (8).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验实验助攻 | WB 实验 (Western Blot) 杂带太多？原因就这几个！
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，此，NK，Mac，Tsub[AS] 分子质量(kDa)和结构：gpl50(整合素α) 功 能：iC3b、C3dg、Fg受体，调理吞噬 CD11 CD11a, b and c all have same beta chain (CD18) Members of integrin receptor family; heterodimers of noncovalently
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