- 询价
- Cell Signaling Technology
- 4190
- USA
- 2025年12月06日
- W, IP, IF-IC
- Rabbit
- H,M,R
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
Acetyl-CoA Carboxylase 1 Antibody
- 抗原：
synthetic peptide corresponding to the sequence of human acetyl-CoA carboxylase 1 protein
- 应用范围：
W, IP, IF-IC
- 宿主：
Rabbit
- 适应物种：
H,M,R
- 库存：
大量
- 保质期：
详见说明书
- 供应商：
CST
- 级别：
详见MSDS文件
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP IF-IC | H M R | Endogenous | 265 | Rabbit |
| Protocols | |
|---|---|
| Specificity / Sensitivity | Acetyl-CoA Carboxylase 1 Antibody detects endogenous levels of total acetyl-CoA carboxylase 1 protein. Immunofluorescence data indicate that the antibody is more reactive to rodent than human proteins. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human acetyl-CoA carboxylase 1 protein. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from HeLa cells, mock transfected or transfected with either SignalSilence® ACC1 siRNA or SignalSilence® ACC2 siRNA, using Acetyl-CoA Carboxylase 1 Antibody and β-Actin (13E5) Rabbit mAb #4970. Western Blotting
Western blot analysis of extracts from various cell types using Acetyl-CoA Carboxylase 1 Antibody. IF-IC
Confocal immunofluorescent analysis of HCC827 (left) and C2C12 cells (right) using Acetyl-CoA Carboxylase 1 Antibody (green). Actin filaments have been labeled with DY-554 phalloidin (red). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye). |
| Background | Acetyl-CoA carboxylase (ACC) catalyzes the carboxylation of acetyl-CoA to malonyl-CoA (1). It is the key enzyme in the biosynthesis and oxidation of fatty acids (1). In rodents, the 265 kDa ACC1 (ACCα) form is primarily expressed in lipogenic tissues, while the 280 kDa ACC2 (ACCβ) form is the main isoform in oxidative tissues (1,2). However, in humans, ACC2 is the predominant isoform in both lipogenic and oxidative tissues (1,2). Phosphorylation by AMPK at Ser79 or by PKA at Ser1200 inhibits the enzymatic activity of ACC (3). ACC is a potential target of anti-obesity drugs (4,5). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验The study of cellular function of a particular gene can be advanced by either specifically eliminating or blocking the function of its gene product. Although antisense RNA has frequently been used for this purpose, the hammerhead ribozyme
单酰 CoA＋ ADP 磷酸。
存在于线粒体中，是催化下列不可逆反应的酶。 EC6． 4． 1． 1．丙酮酸＋ CO2 ＋ ATP＋ H2 O→草酰乙酸＋ ADP＋ Pi，Δ Go ′＝ -0.5kcal．广泛存在于动物、霉菌和酵母中，但在植物体和大部分细菌中却不含此酶。在三羧酸循环中，它是供给草酰乙酸的主要补充反应。为一种变构酶，有乙酰 CoA时，其活性存在，同时含有生物素作为和 CO2 反应的酶的辅酶。分子量约 65万，有很多亚基。最适 pH为 4.8。
技术资料暂无技术资料 索取技术资料
