Sample:
K562 (Human) Cell Lysate at 30 ug
HepG2 (Human) Cell Lysate at 30 ug
Primary: Anti-SLC40A1 (bs-4906R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 63 kD
Observed band size: 63 kD
- ￥1180 - 2800
- Bioss
- bs-4906R
- 2025年10月16日
- 产品信息以Bioss网站为准
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-4906R |
| 英文名称 | SLC40A1 Rabbit pAb |
| 中文名称 | 细胞膜铁转运蛋白FP1抗体 |
| 英文别名 | Ferroportin 1; Ferroportin-1; FPN1; HFE4; IREG1; Iron regulated transporter 1; Iron-regulated transporter 1; MTP1; S40A1_HUMAN; SLC40A1; Solute carrier family 40 member 1; MST079; MSTP079; MTP1; SLC11A3. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Dog, Pig, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human SLC40A1/FPN1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 63 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Metabolism > Pathways and Processes > Cofactors, Vitamins / minerals > Vitamins / minerals Signal Transduction > Metabolism > Vitamins / Minerals |
| 亚基 | Belongs to the S1LC40A transporter family. |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. Note=Localized to the basolateral membrane of polarized epithelial cells. |
| 组织特异性 | Expressed in placenta, intestine, muscle and spleen. |
| 相似性 | Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. |
| 功能 | May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SLC40A1 may be involved in iron export from duodenal epithelial cells and also in transfer of iron between maternal and fetal circulation. It mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4, an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
Sample:
A673(Human) Cell Lysate at 30 ug
Primary: Anti-SLC40A1 (bs-4906R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 63 kD
Observed band size: 65 kD
A673(Human) Cell Lysate at 30 ug
Primary: Anti-SLC40A1 (bs-4906R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 63 kD
Observed band size: 65 kD
Sample:
Lane 1: Human Hepg2 cell lysates
Lane 2: Human K562 cell lysates
Lane 3: Human Molt-4 cell lysates
Lane 4: Human Jurkat cell lysates
Primary: Anti-SLC40A1 (bs-4906R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 63 kDa
Observed band size: 60 kDa
Lane 1: Human Hepg2 cell lysates
Lane 2: Human K562 cell lysates
Lane 3: Human Molt-4 cell lysates
Lane 4: Human Jurkat cell lysates
Primary: Anti-SLC40A1 (bs-4906R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 63 kDa
Observed band size: 60 kDa
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文献和实验该产品被引用文献
[IF={{ 8.8 }}] {Mun SH. et al. Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons.. CELL REP. 2023 Jul;42(7):112746-112746} {Other} {}
[IF={{ 7.5 }}] {Xu Zhu. et al. Brusatol induces ferroptosis in oesophageal squamous cell carcinoma by repressing GSH synthesis and increasing the labile iron pool via inhibition of the NRF2 pathway. BIOMED PHARMACOTHER. 2023 Nov;167:115567} {WB,IHC} {Mouse}
[IF={{ 7.31 }}] {Huang Bin. et al. Dapagliflozin Ameliorates Renal Tubular Ferroptosis in Diabetes via SLC40A1 Stabilization. OXID MED CELL LONGEV. 2022;2022:9735555} {WB,IP} {Mouse,Human}
[IF={{ 5.778 }}] {Luo R et al. Clostridium perfringens beta2 toxin induced in vitro oxidative damage and its toxic assessment in porcine small intestinal epithelial cell lines. Gene. 2020 Oct 30;759:144999.} {WB} {Rat}
[IF={{ 5.778 }}] {Zixuan Liu. et al. Tetrachlorobenzoquinone exposure triggers ferroptosis contributing to its neurotoxicity. Chemosphere. 2021 Feb;264:128413} {WB} {Rat}
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SLC40A1 Rabbit pAb(bs-4906R)-50ul/100ul/200ul
￥1180 - 2800
