Sample:
Heart (Mouse) Lysate at 40 ug
Heart (Rat) Lysate at 40 ug
Primary: Anti-Atrial natriuretic factor (bs-2040R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 3/17 kD
Observed band size: 15 kD
- ￥1180 - 2800
- Bioss
- bs-2040R
- 2025年10月16日
- 产品信息以Bioss网站为准
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-2040R |
| 英文名称 | Atrial natriuretic factor Rabbit pAb |
| 中文名称 | 心房钠尿因子/心钠素/心房利钠肽/ANP抗体 |
| 英文别名 | Prepronatriodilatin; ANF_HUMAN; Cardiodilatin; ANF; Atrial natriuretic factor; CDD ANF; CDP; PND; Prepronatriodilatin; NPPa; Natriuretic peptides A; Atrial natriuretic peptide; CDD-ANF; ANP. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse, Rat (Dog, Pig, Cow, Horse, Rabbit, Sheep, GuineaPig) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human ANP |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 3/17 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Blood Cardiovascular > Blood > Blood Pressure regulation Cardiovascular > Heart > Hypertrophy Cardiovascular > Heart > Hypertrophy > Hormones Signal Transduction > Growth Factors/Hormones > Hormones |
| 亚基 | Interacts with NPR1. |
| 亚细胞定位 | Secreted. |
| 翻译后修饰 | Cleaved by CORIN upon secretion to produce the functional hormone. |
| 相似性 | Belongs to the natriuretic peptide family. |
| 功能 | Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009].. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
Paraformaldehyde-fixed, paraffin embedded Rat Heart; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with Atrial natriuretic factor Polyclonal Antibody, Unconjugated (bs-2040R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Heart; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with Atrial natriuretic factor Polyclonal Antibody, Unconjugated (bs-2040R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Mouse Heart; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with Atrial natriuretic factor Polyclonal Antibody, Unconjugated (bs-2040R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
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文献和实验该产品被引用文献
[IF={{ 4.432 }}] {Ruomiao Li. et al. Protective effects of dioscin against isoproterenol-induced cardiac hypertrophy via adjusting PKCε/ERK-mediated oxidative stress. Eur J Pharmacol. 2021 Sep;907:174277} {WB} {Rat}
[IF={{ 1.7 }}] {Straub, Rainer H., et al. "Increased extracellular water measured by bioimpedance and by increased serum levels of atrial natriuretic peptide in RA patients—signs of volume overload." Clinical Rheumatology (2016): 1-11} {IHC} {="Human"}
[IF={{ 0 }}] {Malinowski, Nadezhda. Erhöhtes extrazelluläres Wasser gemessen durch Bioimpedanz und erhöhter Serumspiegel von atrialem natriuretischen Peptid bei rheumatoider Arthritis–Anzeichen von Volumenüberlastung. Diss. 2015.} {IHC} {="Human"}
相关实验
can occur between AT receptors and receptors for atrial natriuretic factor (ANF) (2 ), bradykinin (3 ), catecholamines (4 ), adrenocorticotropin releasing hormone (5 ), vasopressin (6 ), and dopamine (7 ). Ang II is also found to indirectly modulate
Induction and Analysis of Cardiac Hypertrophy in Transgenic Animal Models
. After periods between 3 and 21 d, parameters such as cardiac hemodynamics, morphologic alterations, and expression of marker genes (e.g., the gene for atrial natriuretic peptide) are analyzed in genetically modified animals and compared with controls elucidating
因子”。但这方面还有许多问题有待阐明。有些资料也未能证实这种物质的存在。 五、心房利钠因子的作用 80年代初以来，哺乳动物心房中心房利钠因子（atrial natriuretic factor，ANF）的发现和随后一系列的研究，为人们理解体液容量和血压的调节开辟了一个新的时代，也是医学和生理学研究的一个重大进展。ANF后来也被称为心房利钠多肽（atrial natriuretic polypeptide，ANP）因为已经证明它是一种多肽。 ANP主要存在于哺乳动物其中也包括人的心房
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Atrial natriuretic factor Rabbit pAb(bs-2040R)-50ul/100ul/200ul
￥1180 - 2800
