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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-1557G |
| 英文名称 | HBsAg Goat pAb |
| 中文名称 | 山羊抗人乙肝表面抗原抗体（包被） |
| 英文别名 | L glycoprotein; L-HBsAg; LHB; Large S protein; Large surface protein; Major surface antigen; S; HBSAG_HBVC5. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | HBV |
| 抗体来源 | Goat |
| 免疫原 | Recombinant HBsAg protein |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 44 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M PBS (pH7.4) with 0.02% Proclin300. |
| 研究领域 | Microbiology > Organism > Virus > DNA Virus > double stranded DNA Virus > Hepatitis B |
| 亚基 | Li-HBsAg interacts with capsid protein and with HDV Large delta antigen. Isoform M associates with host chaperone CANX through its pre-S2 N glycan. This association may be essential for M proper secretion. |
| 亚细胞定位 | Virion membrane. |
| 翻译后修饰 | Isoform M is N-terminaly acetylated at a ratio of 90%, and N-glycosylated at the pre-S2 region.
Myristoylated. |
| 相似性 | Belongs to the orthohepadnavirus major surface antigen family. |
| 功能 | The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assumes fusion between virion membrane and endosomal membrane (Probable). In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.
The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
Lane 1: Recombinant HBsAg protein(bs-41420P)
Primary: Anti-HBsAg (bs-1557G) at 1/1000 dilution
Secondary: IRDye800CW Donkey anti-Goat IgG at 1/20000 dilution
Predicted band size: 44 kDa
Observed band size: 20 kDa
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文献和实验[IF={{ preprint }}] {Zhenzhen Shi. et al.Modeling of hepatitis B virus infection spread in primary human hepatocytes.biorxiv.2025 Feb 7:2025.02.05.636596.} {IF} {Human}
[IF={{ 8.1 }}] {Luo Chuanjin. et al. Hepatitis B surface antigen hijacks TANK-binding kinase 1 to suppress type I interferon and induce early autophagy. CELL DEATH DIS. 2025 Apr;16(1):1-16} {ICC} {Human}
[IF={{ 7.1 }}] {Satoshi Shigeno. et al. Intrahepatic Exhausted Antiviral Immunity in an Immunocompetent Mouse Model of Chronic Hepatitis B. CELL MOL GASTROENTER. 2024 Sep;:101412} {IHC} {Mouse}
[IF={{ 6.286 }}] {Yuki Takamatsu. et al. A novel anti-HBV agent, E-CFCP, restores Hepatitis B virus (HBV)-induced senescence-associated cellular marker perturbation in human hepatocytes. VIRUS RES. 2023 May;329:199094} {ICC} {Human}
[IF={{ 5.701 }}] {Ito Daisuke. et al. Spermidine enhances the efficacy of adjuvant in HBV vaccination in mice. Hepatology Communications. 2023 Mar;7(4):e0104} {IHC} {Mouse}
乙型肝炎病毒（HBV）的父婴传播已讨论多年，由于HBV至今不能分离培养，研究传播仍有一定困难。本研究以巢式多聚酶链反应（PCR）与序列分析的方法研究父儿所携HBV在分子病毒学方面的特点，试图从分子水平证明HBV父儿传播的可能，并探索在病原体未分离成功的情况下研究传播的可行方法。1. 材料与方法1.1 研究对象从1995年3月至1996年3月在湖南省某县以HBsAg为指标筛检前来终止妊娠的孕妇及其配偶。选择8名男性HBV携带者与其子宫内受染有胎儿为研究对象。携带者以ELISA检测常规五项HBV
with the Western blot procedure as usual. Example Antibody gives good positive results at 2 µg/mL. Normally nitrocellulose is incubated in a final volume of 10 mLs. Combine 20 µg of the antibody with 100 µg of the peptide in 1mL of P(T)BS-milk. Incubate
【资源】全面归类网址：毕赤酵母表达各种来源蛋白（细菌，真菌，植物，人类等）
multifunctional enzyme (perMFE-II)I[189]Rat procathepsin BS, 100 mg/L, α-MF[190, 191]Rat serotonin transporterI, inactivr514Rat tumor necrosis factor-αI, 10 mg/L, active382Sea raven type II antifreeze protein (SRAFP)S, 36 g/L, α-MF, stable[192, 193], 499Shark 17
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