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8-OHdG Rabbit pAb(bs-1278R)-50

ul/100ul/200ul

价格￥1180 - 2800

品牌Bioss
货号bs-1278R
更新日期2026年10月13日

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规格：
50ul/100ul/200ul

规格：	50ul	产品价格：	￥1180.0
规格：	100ul	产品价格：	￥1980.0
规格：	200ul	产品价格：	￥2800.0

产品编号	bs-1278R
英文名称	8-OHdG (DNA/RNA Damage) Rabbit pAb
中文名称	8-羟基脱氧鸟苷抗体
英文别名	8-hydroxy-2'-deoxyguanosine; 2'-Deoxy-8-oxoguanosine; 7, 8-Dihydro-8-oxo-2'-deoxyguanosine; 8-Oxo-7, 8-dihydro-2'-deoxyguanosine; 8-Oxo-7, 8-dihydrodeoxyguanosine; 2'-Deoxy-8-oxo-D-guanosine; 8-Oxo-7, 8-dihydro-2μ-deoxyguanosine, 8-Oxo-dG; 2'-Deoxy-8-hydroxyguanosine;
中文别名	8-OH-脱氧鸟嘌呤; 8-羟基-2'-脱氧鸟嘌呤; 2'-脱氧-7,8-二氢-8-氧代鸟苷; 8-羟基-2-脱氧鸟苷; 8-羟基脱氧鸟苷; 2'-脱氧-8-氧代鸟嘌呤; 8-氧-2'-脱氧鸟苷; 核酸氧化8-羟基脱氧鸟苷; 8-羟基-2′-脱氧鸟苷;
产品应用	IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
交叉反应	Species independent
抗体来源	Rabbit
免疫原	KLH conjugated 8-OHdG
亚型	IgG
性状	Liquid
纯化方法	affinity purified by Protein A
克隆类型	Polyclonal
理论分子量	0.283 kDa
浓度	1mg/ml
储存液	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域	Cell Biology > Other Antibodies > Oxidative Stress Epigenetics and Nuclear Signaling > DNA / RNA > DNA / Nucleotides Metabolism > Pathways and Processes > Redox metabolism > Oxidative stress
功能	Oxoguanine 8 (8-Oxoguanine) is a mutagenic oxidative damage product of guanine. Guanine is the main target for reactive oxygen species in DNA, with 8-oxoguanine being the most frequent base lesion. Thus formation of 8-oxoguanine is an important biomarker of oxidative damage to DNA. It is primarily repaired by the DNA glycosylase OGG1.
保存条件	Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料	8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer's disease.

应用	推荐稀释比例
{IHC-P}	{1:100-500}
{IHC-F}	{1:100-500}
{IF}	{1:100-500}

Tissue/cell: rat brain tissue(left panel was injury,Right panel was normal); 4% P‌‌araformaldehyde-fixed and paraffin-embedded;
_x000D_ Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
_x000D_ Incubation: Anti-8-OHdG Polyclonal Antibody, Unconjugated(bs-1278R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
_x000D_

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