- ￥2310 - 25190
- Sino Biological
- 北京
- 11084-H08H
- 2025年08月12日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20℃ to -80℃
- 保质期：
12个月
- 英文名：
Recombinant Human TREM2 Protein (ECD,His Tag)
- 库存：
99
- 供应商：
北京义翘神州科技股份有限公司
- 规格：
1.00 mg/50.00 µg/100.00 µg
| 规格： | 1.00 mg | 产品价格： | ￥25190.0 |
|---|---|---|---|
| 规格： | 50.00 µg | 产品价格： | ￥2310.0 |
| 规格： | 100.00 µg | 产品价格： | ￥3870.0 |
蛋白名称：Human TREM2 Protein (ECD,His Tag)
蛋白构建：A DNA sequence encoding the extracellular domain of human TREM2 (NP_061838.1) (Met1-Ser174) was expressed fused with a polyhistidine tag at the C-terminus.
表达宿主：HEK293 Cells
蛋白纯度：> 90 % as determined by SDS-PAGE
蛋白活性：0
蛋白内毒素：< 1.0 EU per μg of the protein as determined by the LAL method
预测N端：His 19
蛋白分子量：The secreted recombinant human TREM2 comprises 167 amino acids with a predicted molecular mass of 18.9 kDa. As a result of glycosylation, the apparent molecular mass of rhTREM2 is approximately 30-40 kDa band in SDS-PAGE under reducing conditions.
蛋白NP号：NP_061838.1
蛋白氨基酸序列：Met1-Ser174
蛋白标签：C-His
蛋白保存条件：Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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文献和实验2, Zhao Y, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.Neuron, PubMed ID: 29518356
3, Woollacott IOC, et al. Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup.Alzheimer's research & therapy, PubMed ID: 30111356
4, Jensen CS, et al. Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasma.Experimental gerontology, PubMed ID: 30980923
5, Zhao P, et al. Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice.mAbs, PubMed ID: 35921534
6, Xie M, et al. TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration.Nature neuroscience, PubMed ID: 34916658
7, Arsenault R, et al. sTREM2 Differentially Affects Cytokine Expression in Myeloid-Derived Cell Models via MAPK-JNK Signaling Pathway.Biology, PubMed ID: 38392305
8, Reichert Plaska C, et al. Evidence for reduced anti-inflammatory microglial phagocytic response in late-life major depression.Brain, behavior, and immunity, PubMed ID: 38795783
Chromatin Interaction Analysis Using Paired‐End Tag Sequencing
Analysis using Paired?End Tag sequencing (ChIA?PET) is a technique developed for large?scale, de novo analysis of higher?order chromatin structures. Cells are treated with formaldehyde to cross?link chromatin interactions, DNA segments bound by protein
HPLC With Electrochemical Detection Analysis of 3-Nitrotyrosine in Human Plasma
have been previously discussed ( 1 , 11 ). The primary focus of this chapter is to discuss the bioanalytical methodologies and techniques used to analyze 3-NO 2 -Tyr and its tyrosine variants in human plasma samples using direct HPLC-ECD. Other available bioanalytical
Purification of Human Multiprotein Complexes using OneSTrEP Technology
sufficient for visualising single protein bands by Coomassie Blue staining (Figure 1). The Strep -tag®II (SAWRHPQFGG) and its “double” sister, the One-STrEP-tag (tandem arrangement of Strep -tag®II, here called OneStrep), are reasonably small protein
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