- 询价
- StressMarq
- 加拿大
- SPR-121
- 2026年04月11日
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- 详细信息
- 技术资料
- 保存条件：
-20ºC
- 保质期：
一年
- 英文名：
Rab5 Protein
- 库存：
大量
- 供应商：
StressMarq
- 规格：
50 µg/100 µg/100 µg x2
| 规格： | 50 µg | 产品价格： | 询价 |
|---|---|---|---|
| 规格： | 100 µg | 产品价格： | 询价 |
| 规格： | 100 µg x2 | 产品价格： | 询价 |
| 产品名称 | Rab5 蛋白 |
| 产品描述 |
重组人Rab5蛋白 |
| 应用范围 | WB, SDS-PAGE |
| 浓度 | 各批次不同，请详见说明书 |
| 标记物 | His 标签 |
| 性质 | 重组 |
| 来源物种 | 人 |
| 表达系统 | 大肠杆菌 (E. coli) |
| 氨基酸序列 | MASRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANSARGRGVDLTEPTQPTRNQCCSN |
| 纯度 | >90% |
产品特性
| 储存缓冲液 | 20mM Tris/HCl, pH 7.5, 0.15M NaCl |
| 储存温度 | -20ºC |
| 运输温度 | 蓝冰或4℃ |
| 纯化方式 | 亲和纯化的 |
| Protein Size | 分子量约为26kD |
| 引用该产品 | Human Recombinant Rab5 Protein (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-121) |
| 分析证书 | 该蛋白已经通过SDS-PAGE检测证明纯度大于90%. |
生物学特性
| 别名 | Rab 5A Protein, RAS associated Protein RAB5A Protein, Ras related Protein Rab 5 A Protein |
| 研究领域 | 热休克, 癌症 |
| 细胞定位 | 细胞核, 细胞质, 细胞质基质 |
| Accession Number | BC001267 |
| GeneID | 5868 |
| Swiss Prot | P20339 |
| 科研背景 | Rab5 is a 24kDa member of the Rab family of small guanosine triphosphatases (GTPases), Ras superfamily. Rab GTPases are central regulators of membrane trafficking in the eukaryotic cell. Their regulatory capacity depends on their ability to cycle between the GDP -bound inactive and GTP-bound active states. This conversion is regulated by GDP/GTP exchange factors (GEPs), GDP dissociation inhibitors (GDIs) and GTPase-activating proteins (GAPs) (1, 2). Activation of a Rab protein is coupled to its association with intracellular membranes, allowing it to recruit downstream effector proteins to the cytoplasmic surface of a subcellular compartment (3). Through these proteins, Rab GTPases regulate vesicle formation, actin- and tubulin-dependent vesicle movement, and membrane fusion(1). Rab proteins contain conserved regions involved in guanine-nucleotide binding, and hyper variable COHO-terminal domains with a cysteine motif implicated in subcellular targeting. Post-translational modification of the cysteine motif with one or two geranyl groups is essential for the membrane association and correct intracellular localization of Rab proteins(3). Each Rab shows a characteristic subcellular distribution (4). In particular, Rab5 is ubiquitously expressed in human tissues. It localizes mainly to early endosomes, but is also present on the plasma membrane. It regulates the fusion between endocytic vesicles and early endosomes, as well as the homotypic fusion between early endosomes (5). Among the proteins recruited by the GTP-bound active Rab5 are Rabaptin-5 and EEA1 (6). Anti-Rab5 may be used as an early endosome marker. |
| 参考资料 | 1. Stenmark H., and Olkkonen V.M. (2001) Genome Biol. 2: 3007.1-3007.7. 2. Takai Y., et al. (2001) Physiol. Rev. 8:, 153-208. 3. Ali B.R., et al. (2004) J. Cell Sci. 117: 6401-6412. 4. Zerial M., and McBride H. (2001) Nat. Rev. Mol. Cell Biol. 2: 107-117. 5. Sonnichsen B., et al. (2000) J. Cell Biol. 149: 901-913 6. Woodman P.G. (2000) Traffic. 1: 695-701. |
产品图片
26kDa 人 Rab5 蛋白 SDS-PAGE (SPR-121).
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重组人Rab5蛋白
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