- ￥3220 - 21000
- Sino Biological
- 北京
- 10084-H02H
- 2025年08月12日
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- 文献和实验
- 技术资料
- 保存条件：
-20℃ to -80℃
- 保质期：
12个月
- 英文名：
Recombinant Human PD-L1 / B7-H1 / CD274 Protein (Fc Tag)
- 库存：
99
- 供应商：
北京义翘神州科技股份有限公司
- 规格：
1.00 mg/100.00 µg/200.00 µg
| 规格： | 1.00 mg | 产品价格： | ￥21000.0 |
|---|---|---|---|
| 规格： | 100.00 µg | 产品价格： | ￥3220.0 |
| 规格： | 200.00 µg | 产品价格： | ￥3870.0 |
重组人 PD-L1 / B7-H1 / CD274 蛋白 (Fc标签)（产品说明）
蛋白名称：Human PD-L1 / B7-H1 / CD274 Protein (Fc Tag)
蛋白构建：A DNA sequence encoding the N-terminal segment (Met 1-Thr 239) of the extracellular domain of human B7-H1 (NP_054862.1) was expressed with C-terminal fused Fc region of human IgG1.
表达宿主：HEK293 Cells
蛋白纯度：> 95 % as determined by SDS-PAGE
蛋白活性：1. Measured by its binding ability in a functional ELISA. Immobilized human PD-1 (Cat: HPLC-10377-H08H) at 2 μg/ml (100 μl/well) can bind human B7-H1(Cat: 10084-H02H), the EC50 of human B7-H1 is 150-600 ng/mL. 2. Using the Octet RED System, the affinity constant (Kd) of PD-L1 Protein, Human, Recombinant (Fc Tag)(10084-H02H) bound to Atezolizuma was 0.5 μM.
蛋白内毒素：< 1.0 EU per μg of the protein as determined by the LAL method
预测N端：Phe 19
蛋白分子量：The recombinant mature human B7-H1/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 459 amino acids and predicts a molecular mass of 52 kDa. As a result of glycosylation, the human B7-H1/Fc monomer migrates as an approximately 65-70 kDa protein in SDS-PAGE under reducing conditions.
蛋白NP号：NP_054862.1
蛋白氨基酸序列：Met1-Thr239
蛋白标签：C-human IgG1-Fc
蛋白保存条件：Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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文献和实验1, Li Y, et al. Dual targeting of TIGIT and PD-1 with a novel small molecule for cancer immunotherapy.Biochemical pharmacology, PubMed ID: 38527557
2, Zhang F, et al. Design, synthesis, anti-tumor activity and mechanism of novel PROTACs as degraders of PD-L1 and inhibitors of PD-1/PD-L1 interaction.Bioorganic & medicinal chemistry, PubMed ID: 39121678
3, Lobaina Y, et al. The Nucleocapsid Protein of SARS-CoV-2, Combined with ODN-39M, Is a Potential Component for an Intranasal Bivalent Vaccine with Broader Functionality. Viruses, PubMed ID:38543783
4, Williams DE, et al. Thorectidiol A Isolated from the Marine Sponge Dactylospongia elegans Disrupts Interactions of the SARS-CoV-2 Spike Receptor Binding Domain with the Host ACE2 Receptor. Journal of natural products, PubMed ID:36657039
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