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- 美国
- 2026年06月14日
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- 详细信息
- 文献和实验
- 技术资料
- 服务名称：
Aptamers Services
- 提供商：
北京安必奇生物科技有限公司
Aptamer synthesis
We can provide you with oligo library. The initial oligonucleotide library is usually 60-80mer with a 20-40 nucleotide random (N) bases that will give rise to a random oligo library.
We also can synthesize the selected aptamer according to your requirements.
Synthetic aptamers are purified by PAGE or HPLC and verified by mass spec.
Aptamer generation
We provide a complete solution of aptamer generation (library synthesis, aptamer selection and validation) for a broad range of targets. At first we synthesize the huge random oligonucleotide pools in which the copies is up to 1015 that are used as the source of the screen for aptamers. Then we use our advanced aptamer generating technologies to select high affinity aptamers from the pool, clone and sequence. Finally, we will test biological function and analytical properties of the selected aptamers by means of a variety of different molecular biological and physicochemical techniques. Affinity and specificity to the target molecule, equilibrium, kinetic, thermodynamic parameters of bio-molecular interaction and the structural stability of aptamers as affinity ligands will all be presented.
Cell SELEX
Creative Biogene also is a leading service provider for cell SELEX (cell aptamer selection). We are experienced to discover aptamers target to proteins located on the cell surface.
Cell SELEX protocol
Aptamer design and modification
After an aptamer is selected we can suggest specific modifications to improve its properties based on your requirements e.g cell delivery, nuclease resistance, duplex stability etc. Moreover, biotinylation, fluorophores, backbone modifications and other functionalizations are all available.
Other services
Services offered by Creative Biogene also include: negative selection (By means of negative selection techniques non-specific binders will be removed), aptamer-based precipitation, aptamer-based sensors and aptamer-based microarrays, allosteric/structure-switching aptamer.
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文献和实验The immobilization procedure to a biosensor surface has a major influence on the measurement results. To characterize the immobilization onto various biolayers, the interaction of DNA anti-thrombin aptamer with the protein thrombin was used
Bioinformatics Workflows and Web Services in Systems Biology Made Easy for Experimentalists
Workflows are useful to perform data analysis and integration in systems biology. Workflow management systems can help users create workflows without any previous knowledge in programming and web services. However the computational skills
Ligand-Regulated Peptide Aptamers
aptamers using the LiRP scaffold in a yeast two-hybrid system, and the screening of those peptide aptamers for a ligand-regulated interaction.
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