- ￥5820
- Sino Biological
- 北京
- 40606-V08B
- 2026年01月26日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20℃ to -80℃
- 保质期：
12个月
- 英文名：
Recombinant Human coronavirus HKU1(isolate N5)Spike Protein(S1+S2 ECD,His)
- 库存：
99
- 供应商：
北京义翘神州科技股份有限公司
- 规格：
100.00 µg
冠状病毒HCoV-HKU1 Coronavirus spike蛋白|Coronavirus spike protein|Coronavirus spike(HCoV-HKU1, C-His)（产品说明）
蛋白名称：Coronavirus spike蛋白, Coronavirus spike protein
蛋白构建：A DNA sequence encoding the human coronavirus HKU1 (isolate N5) (HCoV-HKU1) spike protein (S1+S2 ECD) (Q0ZME7.1) (Met1-Pro1295) was expressed with a polyhistidine tag at the C-terminus.
表达宿主：Baculovirus-Insect Cells
蛋白纯度：> 75 % as determined by SDS-PAGE.
蛋白活性：0
蛋白内毒素：< 1.0 EU per μg protein as determined by the LAL method.
预测N端：Ala 13
蛋白分子量：The recombinant human coronavirus HKU1 (isolate N5) (HCoV-HKU1) spike protein (S1+S2 ECD, His Tag) consists of 1294 amino acids and predicts a molecular mass of 144.4 kDa.
蛋白NP号：Q0ZME7.1
蛋白氨基酸序列：Met1-Pro1295
蛋白标签：C-His
蛋白保存条件：Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
蛋白名称：Coronavirus spike蛋白, Coronavirus spike protein
蛋白构建：A DNA sequence encoding the human coronavirus HKU1 (isolate N5) (HCoV-HKU1) spike protein (S1+S2 ECD) (Q0ZME7.1) (Met1-Pro1295) was expressed with a polyhistidine tag at the C-terminus.
表达宿主：Baculovirus-Insect Cells
蛋白纯度：> 75 % as determined by SDS-PAGE.
蛋白活性：0
蛋白内毒素：< 1.0 EU per μg protein as determined by the LAL method.
预测N端：Ala 13
蛋白分子量：The recombinant human coronavirus HKU1 (isolate N5) (HCoV-HKU1) spike protein (S1+S2 ECD, His Tag) consists of 1294 amino acids and predicts a molecular mass of 144.4 kDa.
蛋白NP号：Q0ZME7.1
蛋白氨基酸序列：Met1-Pro1295
蛋白标签：C-His
蛋白保存条件：Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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文献和实验该产品被引用文献
1, Sakharkar, M; et al. Prolonged evolution of the human B cell response to SARS-CoV-2 infection. Science immunology, PMID: 33622975
2, Klausberger, M; et al. A comprehensive antigen production and characterisation study for easy-to-implement, specific and quantitative SARS-CoV-2 serotests. EBioMedicine, PMID: 33906067
3, Jennewein, MF; et al. Isolation and characterization of cross-neutralizing coronavirus antibodies from COVID-19+ subjects. Cell reports, PMID: 34237283
4, Lin, CY; et al. Pre-existing humoral immunity to human common cold coronaviruses negatively impacts the protective SARS-CoV-2 antibody response. Cell host & microbe, PMID: 34965382
5, Narowski, TM; et al. SARS-CoV-2 mRNA vaccine induces robust specific and cross-reactive IgG and unequal neutralizing antibodies in naive and previously infected people. Cell reports, PMID: 35090596
6, Pattinson, D; et al. A Novel Method to Reduce ELISA Serial Dilution Assay Workload Applied to SARS-CoV-2 and Seasonal HCoVs. Viruses, PMID: 35336970
7, Minervina, AA; et al. SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8 T cells. medRxiv : the preprint server for health sciences, PMID: 34341799
8, Lanz, TV; et al. Limited Neutralization of Omicron by Antibodies from the BNT162b2 Vaccination against SARS-CoV-2. Research square, PMID: 35441169
9, Minervina, AA; et al. SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells. Nature immunology, PMID: 35383307
10, Sun, X; et al. Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2. Nature microbiology, PMID: 35773398
11, Anderson, EM; et al. SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared with SARS-CoV-2 mRNA vaccinations. Cell reports, PMID: 36261003 1
2, Li, Z; et al. Affinity-independent memory B cell origin of the early antibody-secreting cell response in naive individuals upon SARS-CoV-2 vaccination. Immunity, PMID: 39168129
2, Klausberger, M; et al. A comprehensive antigen production and characterisation study for easy-to-implement, specific and quantitative SARS-CoV-2 serotests. EBioMedicine, PMID: 33906067
3, Jennewein, MF; et al. Isolation and characterization of cross-neutralizing coronavirus antibodies from COVID-19+ subjects. Cell reports, PMID: 34237283
4, Lin, CY; et al. Pre-existing humoral immunity to human common cold coronaviruses negatively impacts the protective SARS-CoV-2 antibody response. Cell host & microbe, PMID: 34965382
5, Narowski, TM; et al. SARS-CoV-2 mRNA vaccine induces robust specific and cross-reactive IgG and unequal neutralizing antibodies in naive and previously infected people. Cell reports, PMID: 35090596
6, Pattinson, D; et al. A Novel Method to Reduce ELISA Serial Dilution Assay Workload Applied to SARS-CoV-2 and Seasonal HCoVs. Viruses, PMID: 35336970
7, Minervina, AA; et al. SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8 T cells. medRxiv : the preprint server for health sciences, PMID: 34341799
8, Lanz, TV; et al. Limited Neutralization of Omicron by Antibodies from the BNT162b2 Vaccination against SARS-CoV-2. Research square, PMID: 35441169
9, Minervina, AA; et al. SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells. Nature immunology, PMID: 35383307
10, Sun, X; et al. Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2. Nature microbiology, PMID: 35773398
11, Anderson, EM; et al. SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared with SARS-CoV-2 mRNA vaccinations. Cell reports, PMID: 36261003 1
2, Li, Z; et al. Affinity-independent memory B cell origin of the early antibody-secreting cell response in naive individuals upon SARS-CoV-2 vaccination. Immunity, PMID: 39168129
相关实验
全球首次！分离的新冠病毒中和抗体，还可同时抗 SARS 病毒
抗原表位，为预防和治疗新型冠状病毒肺炎 COVID- 19 提供了可能。图片来源：bioRxiv通常，冠状病毒中和抗体主要靶向介导进入宿主细胞的病毒表面三聚体刺突糖蛋白（Spike Glycoproteins，S 蛋白）。S 蛋白具有介导细胞附着的两个功能亚基：负责受体识别的 S1 亚基（存在四个核心结构域 S1 A/B/C/D）以及促使病毒与细胞膜融合的 S2 亚基。强大的中和抗体通常会靶向 S1 中的受体相互作用位点，从而使受体相互作用失效。之前的研究表明，SARS-CoV- 2 和 SARS-CoV
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Sino Biological 冠状病毒HKU1 Spike重组蛋白 S1+S2 ECD C-His标签
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