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ATCC/DSMZ/ECACC
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人或动物
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- 规格：
T25
| 种属 | 小鼠 |
| 组织来源 | 正常腹腔主动脉组织 |
| 传代比例 | 1:2传代 |
| 完全培养基配置 | 基础培养基500ml ；生长添加剂5ml ；胎牛血清25ml ；双抗5ml |
| 简介 | 腹腔主动脉是人体的大动脉 ，直接延续于发自左心室的主动脉 ，胸腔主动脉 ，沿脊柱左侧下行 ，主要负责腹腔脏器和 腹壁的血液供应。腹腔主动脉内皮细胞组成了主动脉内壁 ，并持续受到血流剪切应力的影响。内皮细胞在切应力的作 用下 ，分泌不同的内皮因子并进而影响血管收缩和生长。主动脉内皮细胞也调节细胞黏附分子的表达来控制和精确调 节炎症反应和组织纤维化。体外培养的原代主动脉内皮细胞可有效地帮助研究者研究内皮功能失调的机理 ，动脉粥样 化等疾病的发病机理以及发展新的治疗方法。 |
TP53 mutation status could be useful in stratifying cancer patients responsive to a certain immunotherapy.Identifying strategies to improve the ef ficacy of immune checkpoint blockade (ICB) remains a major clinical need. Here, we show that therapeutically targeting the prognostic workflow in triple-negative (TNBC) and HER2-positive breast cancer, as well as many other solid tumors. This recognition has come about thanks to standardized visual reporting guidelines, which helped to reduce inter-reader variability. Now, there are ripe opportunities to
Objective: The objective was to assess the roles of 68Ga-PSMA PET/CT and 18F-NaF PET/CT in evaluation of skeletal metastatic lesions in prostate cancer.
Methods: Two hundred consecutive prostate cancer patients who had undergone 68Ga-PSMA PET/CT and 18F-NaF PET/CT at baseline evaluation (n = 80) and following suspected recurrence or disease progression (restaging) (n = 120) were analyzed retrospectively.
Results: PSMA and NAF scans were positive for skeletal metastatic lesions in 67% (134 patients) and negative in 33% (66 patients). The scans were concordant in 80% (160 patients: 66 negative and 94 positive) and discordant in 20% (40 patients). Among 40 discordant results, 14 were baseline and 26 were restaging studies. PSMA detected more number of lesions in 11 (nine baseline and two restaging). These were true positive marrow or lytic metastatic lesions. NaF revealed more number of lesions in 29 (5 initial and 24 restaging). These were false positive on follow-up imaging. No statistical difference (P value = 0.7 by McNemar test) between the two scans for identifying absence or presence of at least one skeletal lesion was noted at baseline staging.
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文献和实验/COX-2/PGE2/EP2-4 pathway with widely used non-steroidal and steroidal anti-inflammatory drugs synergized with ICB in mouse cancer models. We exploited a bilateral surgery model to distinguish responders from non-responders shortly following treatment and identified acute
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