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Biomedical product—P450 Solution
- 规格：
200 µg/ml
Pharmacogenomics is a powerful tool to investigate how an individual's genetic inheritance affects their body's response to drugs. At present, due to drug safety and efficacy issues, approximately one in three drugs has been discontinued during the course of clinical trials[1]. Thus, there is growing interest in the use of pharmacogenomics to predict safety and efficacy of medications in patients. A key component of predictive toxicology is the ability to understand a patient’s genetic composition of cytochrome P450 (CYP450), which is involved in first-pass drug metabolism function of the liver.
The CYP450 family is a major subset of drug-metabolizing enzymes. To date, up to 58 distinct CYP450 genes have been identified for Homo sapiens[2-3]. Their genetic polymorphisms could be used to predict drug efficacy or severe adverse effects, optimize drug dosing and identify distinct subgroups of patients based on their ability to metabolize various drugs.
Currently used CYP450 genotyping tests, such as AmpliChip® (Roche Molecular Systems, Inc.) for testing and CYP2C19, are based on just one or a few polymorphism sites/variants. However, many drugs are metabolized to varying degrees by more than one gene and variant. For all but a small proportion of drugs, identification of single or multiple variants in one or more CYP450 genes may not be sufficient to explain individual differences in metabolism and resulting efficacy or toxicity
Addressing this shortcoming, BGI developed a target region sequencing based methodology, enriching selected genomic regions of the 58 identified CYP450 genes, applying comprehensive pharmacogenomics analysis to predict drug efficacy and toxicity and thus define the patients who will benefit most from the drug. To our knowledge, the product is the first time to analyze by far all identified 58 distinct human CYP450 genes by a single chip at one time. This is an economical, high-throughput and time-saving revolutionary methodology. It can enrich selected genomic regions from dozens of pooled samples’ genomic DNA in a single step, in order to assist physicians seek appropriate treatment for each patient in clinical trials or hospital treatments.
As described below, we examined the data profile of selected CYP450 targeted sequencing to test the performance of this method.
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文献和实验指植物体的两个或两个以上不同性质的单位（从细胞到器官发育的任一阶段）愈合而又重新分离的现象。偶而在畸形的不同花轮之间，可以看到这种愈合后而再分离的现象，例如下位子房向上位子房的复原，就是子房与杯状花托间的解体。
由于各种目的，向血管内或皮下补给血液以外的液体的总称。根据目的不同，可用电解质、氨基酸、糖溶液等。在日本，有时使病人口服这些溶液（补液）也称输液。
Hyperpolarized Molecules in Solution
of dynamic nuclear polarization (DNP) and para-hydrogen induced polarization (PHIP), two methods used to generate hyperpolarized molecules in aqueous solution.
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