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Tocris货号3742-10mg与50mg现货RepSox
上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商- ￥3038.01
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 库存：
30⁺瓶
- 英文名：
RepSox
- CAS号：
446859-33-2
- 保质期：
1年
- 供应商：
上海睿安生物19121878899
- 保存条件：
2-8°C
- 规格：
10mg/瓶
Tocris货号3742-10mg现货RepSox上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商
Tocris货号3742-50mg现货RepSox上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商
Description:Potent and selective inhibitor of TGF-βRI
Alternative Names:E-616452,SJN 2511,ALK5 Inhibitor II
Chemical Name:2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
Purity:≥99%
Biological Activity
RepSox is a potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 values are 4 and 23 nM for TGF-β type I receptor autophosphorylation and binding respectively). RepSox is selective for TGF-β type I receptor over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 μM). Enhances the efficiency of cellular reprogramming (see our protocols below); also used in protocols to generate CiPSCs from MEFs or β cells from hPSCs (see below); used in protocols to generate pancreatic beta cells from hPSCs or CiPSCs from MEFs. Replaces Sox2 by inducing Nanog expression.
RepSox synthesized to Ancillary Material Grade also available.
For more information about how RepSox may be used, see our protocols: Highly Efficient Generation of CiPSCs from MEFs, Generation of β cells from hPSCs, Reprogramming MEFs into Skeletal Muscle Progenitors.
Technical Data
M.Wt:287.32
Formula:C17H13N5
Solubility:Soluble to 100mM in DMSO and to 20 mM in ethanol
Purity:≥99%
Storage:Store at +4°C
CAS No:446859-33-2
The technical data provided above is for guidance only.For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only,unless stated otherwise.
Background References
- Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors
KF Cogger, A Sinha, F Sarangi, EC McGaugh, D Saunders, C Dorrell, S Mejia-Guer, Y Aghazadeh, JL Rourke, RA Screaton, M Grompe, PR Streeter, AC Powers, M Brissova, T Kislinger, MC Nostro
Nat Commun, 2017;8(1):331. - The metalloprotease ADAM12 regulates the effector function of human Th17 cells.
Zhou A, El Hed A, Mercer F, Kozhaya L, Unutmaz D
PLoS ONE, 2013;8(11):e81146. - GARP-TGF-beta complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo.
Zhou A, Kozhaya L, Fujii H, Unutmaz D
J Immunol, 2013;190(10):5057-64. - Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-γ type I receptor inhibitors.
Gellibert et al.
J.Med.Chem., 2004;47:4494 - Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors.
Li et al.
Cell Stem Cell, 2009;4:16 - A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog.
Ichida et al.
Cell Stem Cell, 2009;5:491 - Stem-Cell-Derived beta-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity
TM Triolo, JQ Matuschek, R Castro-Gut, AH Shilleh, SPM Williams, MS Hansen, K McDaniel, JM Barra, A Michels, HA Russ
Cells, 2022;11(23):.
Citations for RepSox
The citations listed below are publications that use Tocris products. Selected citations for RepSox include:
9 Citations: Showing 1 - 9
- Generation of induced pluripotent stem cell-derived beta-cells in blood amino acids-like medium.
Authors: Yusuke Et al.
Biol Open 2023;12 - Preventing VEGF-Mediated Vascular Permeability by Experimentally Potentiating BBB Characteristics in Endothelial Cells.
Authors: Peter D Et al.
Methods Mol Biol 2022;2475:259-274 - Sufu- And Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals.
Authors: Yung Et al.
Nat.Commun. 2019;10:4647 - Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors.
Authors: Segal Et al.
Nat Commun 2019;10:3350 - Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages.
Authors: Lichtenberger Et al.
Nat Commun 2016;7:10537 - Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
Authors: Mou Et al.
Cell: Stem Cell 2016;19:217 - Differential TGF-β Signaling in Glial Subsets Underlies IL-6-Mediated Epileptogenesis in Mice.
Authors: Alon Et al.
J Immunol 2015;195:1713-22 - GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo.
Authors: Zhou Et al.
J Immunol 2013;190:5057 - Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments.
Authors: Li Et al.
Am J Physiol Renal Physiol 2013;13:1969
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.
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文献和实验该产品被引用文献
Tocris货号3742-10mg现货RepSox上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商
Tocris货号3742-50mg现货RepSox上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商
Description:Potent and selective inhibitor of TGF-βRI
Alternative Names:E-616452,SJN 2511,ALK5 Inhibitor II
Chemical Name:2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
Purity:≥99%
Biological Activity
RepSox is a potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 values are 4 and 23 nM for TGF-β type I receptor autophosphorylation and binding respectively). RepSox is selective for TGF-β type I receptor over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 μM). Enhances the efficiency of cellular reprogramming (see our protocols below); also used in protocols to generate CiPSCs from MEFs or β cells from hPSCs (see below); used in protocols to generate pancreatic beta cells from hPSCs or CiPSCs from MEFs. Replaces Sox2 by inducing Nanog expression.
RepSox synthesized to Ancillary Material Grade also available.
For more information about how RepSox may be used, see our protocols: Highly Efficient Generation of CiPSCs from MEFs, Generation of β cells from hPSCs, Reprogramming MEFs into Skeletal Muscle Progenitors.
Technical Data
M.Wt:287.32
Formula:C17H13N5
Solubility:Soluble to 100mM in DMSO and to 20 mM in ethanol
Purity:≥99%
Storage:Store at +4°C
CAS No:446859-33-2
The technical data provided above is for guidance only.For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only,unless stated otherwise.
Background References
- Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors
KF Cogger, A Sinha, F Sarangi, EC McGaugh, D Saunders, C Dorrell, S Mejia-Guer, Y Aghazadeh, JL Rourke, RA Screaton, M Grompe, PR Streeter, AC Powers, M Brissova, T Kislinger, MC Nostro
Nat Commun, 2017;8(1):331. - The metalloprotease ADAM12 regulates the effector function of human Th17 cells.
Zhou A, El Hed A, Mercer F, Kozhaya L, Unutmaz D
PLoS ONE, 2013;8(11):e81146. - GARP-TGF-beta complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo.
Zhou A, Kozhaya L, Fujii H, Unutmaz D
J Immunol, 2013;190(10):5057-64. - Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-γ type I receptor inhibitors.
Gellibert et al.
J.Med.Chem., 2004;47:4494 - Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors.
Li et al.
Cell Stem Cell, 2009;4:16 - A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog.
Ichida et al.
Cell Stem Cell, 2009;5:491 - Stem-Cell-Derived beta-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity
TM Triolo, JQ Matuschek, R Castro-Gut, AH Shilleh, SPM Williams, MS Hansen, K McDaniel, JM Barra, A Michels, HA Russ
Cells, 2022;11(23):.
Citations for RepSox
The citations listed below are publications that use Tocris products. Selected citations for RepSox include:
9 Citations: Showing 1 - 9
- Generation of induced pluripotent stem cell-derived beta-cells in blood amino acids-like medium.
Authors: Yusuke Et al.
Biol Open 2023;12 - Preventing VEGF-Mediated Vascular Permeability by Experimentally Potentiating BBB Characteristics in Endothelial Cells.
Authors: Peter D Et al.
Methods Mol Biol 2022;2475:259-274 - Sufu- And Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals.
Authors: Yung Et al.
Nat.Commun. 2019;10:4647 - Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors.
Authors: Segal Et al.
Nat Commun 2019;10:3350 - Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages.
Authors: Lichtenberger Et al.
Nat Commun 2016;7:10537 - Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
Authors: Mou Et al.
Cell: Stem Cell 2016;19:217 - Differential TGF-β Signaling in Glial Subsets Underlies IL-6-Mediated Epileptogenesis in Mice.
Authors: Alon Et al.
J Immunol 2015;195:1713-22 - GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo.
Authors: Zhou Et al.
J Immunol 2013;190:5057 - Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments.
Authors: Li Et al.
Am J Physiol Renal Physiol 2013;13:1969
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.
文献支持
Tocris货号3742-10mg与50mg现货RepSox上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商
￥3038.01
