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- 文献和实验
- 技术资料
- CAS号：
25518-54-1
- 保存条件：
2-8°C
- 保质期：
1年
- 英文名：
Lauroyl-L-carnitine
- 库存：
100⁺瓶
- 供应商：
上海睿安生物13611631389
- 规格：
50mg/瓶
Sigma货号39953-10mg月桂酰-L-肉碱(Lauroyl-L-carnitine)上海睿安生物13611631389
Sigma货号39953-50mg月桂酰-L-肉碱(Lauroyl-L-carnitine)上海睿安生物13611631389
月桂酰-L-肉碱
≥95.0%(HPLC)
别名:(-)-月桂酰肉碱，十二烷酰基肉碱，(2 R )-3-羧基- N 、N、N-三甲基-2-[（1-氧代十二烷基)氧基]-1-丙胺 内盐，L-十二酰肉碱酯，C12-肉碱，十二酰-L-肉碱
说明
一般描述
月桂酰-L-肉碱，也称十二烷酰肉碱，是一种酰肉碱化合物，在能量代谢中起关键作用。这种赖氨酸的代谢产物是在肝脏中由蛋氨酸合成，它是各种代谢过程中必必不可少的物质，也是生物化学和代谢组学研究的重要试剂。其浓度可作为诊断的指标，特别是在肉碱缺乏症患者中，它对疾病活动的评估以及HIV和慢性乙肝炎感染等疾病的诊断非常重要。此外，月桂酰-L-肉碱与脂肪酸氧化障碍(包括长链酰基辅酶A 脱氢酶缺乏症、肉碱棕榈酰转移酶 I/II缺乏症)有关，这一点进一步增强了它与代谢研究和诊断的相关性。在癌症组织和人血清和组织活检中也检测出了这种酰肉碱化合物，这一点扩宽了它的应用和对各种代谢组学研究领域的潜在贡献。
应用:月桂酰-L-肉碱可用于生化研究和代谢组学研究。
生化/生理作用:月桂酰-L-肉碱是一种酰基肉碱，存在于长链酰基CoA脱氢酶缺乏症、肉碱棕榈酰转移酶Ⅰ缺乏症、肉碱棕榈酰转移酶Ⅱ缺乏症等脂肪酸氧化障碍中。
特点和优势
- 可用于代谢组学和生物化学研究
- 用于多种研究应用的优质化合物
同行评审论文(部分文献)
Targeting Peripheral CB1 Receptors Reduces Ethanol Intake via a Gut-Brain Axis.
Grzegorz Godlewski et al.
Cell metabolism, 29(6), 1320-1333 (2019-05-21)
Endocannabinoids acting on the cannabinoid-1 receptor (CB1R) or ghrelin acting on its receptor (GHS-R1A) both promote alcohol-seeking behavior, but an interaction between the two signaling systems has not been explored. Here, we report that the peripheral CB1R inverse agonist JD5037
The pattern of urinary acylcarnitines determined by electrospray mass spectrometry: a new tool in the diagnosis of diabetes mellitus.
M Möder et al.
Analytical and bioanalytical chemistry, 375(2), 200-210 (2003-02-01)
l-Carnitine and its esters are products of intermediary metabolism of organisms. The distribution pattern or the favored excretion of individual acylcarnitines tells something about metabolic diseases. The determination of the urinary acylcarnitine pattern by flow injection analysis (FIA)-electrospray ionization (ESI)-mass
Mitochondrial very-long-chain acyl-coenzyme A dehydrogenase deficiency: clinical characteristics and diagnostic considerations in 30 patients.
C Vianey-Saban et al.
Clinica chimica acta; international journal of clinical chemistry, 269(1), 43-62 (1998-03-14)
Very-long-chain acyl-CoA dehydrogenase (VLCAD) is an enzyme catalyzing the dehydrogenation of long-chain fatty acids in the first step of mitochondrial fatty acid oxidation. Using an ETF (electron transfer flavoprotein, the physiological electron acceptor of VLCAD) reduction assay, we identified VLCAD
Selective screening for fatty acid oxidation disorders by tandem mass spectrometry: difficulties in practical discrimination.
Yosuke Shigematsu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 792(1), 63-72 (2003-06-28)
In a selective screening for fatty acid oxidation disorders by tandem mass spectrometry, we tested the diagnostic ratios and acylcarnitine concentrations in sera or blood spots, which were reported to be specific to very long-chain acyl CoA dehydrogenase deficiency, carnitine
Isolation of acylcarnitines from urine: a comparison of methods and application to long-chain acyl-CoA dehydrogenase deficiency.
R J Morrow et al.
Clinica chimica acta; international journal of clinical chemistry, 211(1-2), 73-81 (1992-10-15)
Carnitine esters from acetylcarnitine (C2 acyl chain) to octadecanoylcarnitine (C18 acyl chain) can be extracted from urine with recoveries of greater than 80%. However, to obtain such recoveries, it is important to choose the method of extraction appropriate to the
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文献和实验该产品被引用文献
Sigma货号39953-10mg月桂酰-L-肉碱(Lauroyl-L-carnitine)上海睿安生物13611631389
Sigma货号39953-50mg月桂酰-L-肉碱(Lauroyl-L-carnitine)上海睿安生物13611631389
月桂酰-L-肉碱
≥95.0%(HPLC)
别名:(-)-月桂酰肉碱，十二烷酰基肉碱，(2 R )-3-羧基- N 、N、N-三甲基-2-[（1-氧代十二烷基)氧基]-1-丙胺 内盐，L-十二酰肉碱酯，C12-肉碱，十二酰-L-肉碱
说明
一般描述
月桂酰-L-肉碱，也称十二烷酰肉碱，是一种酰肉碱化合物，在能量代谢中起关键作用。这种赖氨酸的代谢产物是在肝脏中由蛋氨酸合成，它是各种代谢过程中必必不可少的物质，也是生物化学和代谢组学研究的重要试剂。其浓度可作为诊断的指标，特别是在肉碱缺乏症患者中，它对疾病活动的评估以及HIV和慢性乙肝炎感染等疾病的诊断非常重要。此外，月桂酰-L-肉碱与脂肪酸氧化障碍(包括长链酰基辅酶A 脱氢酶缺乏症、肉碱棕榈酰转移酶 I/II缺乏症)有关，这一点进一步增强了它与代谢研究和诊断的相关性。在癌症组织和人血清和组织活检中也检测出了这种酰肉碱化合物，这一点扩宽了它的应用和对各种代谢组学研究领域的潜在贡献。
应用:月桂酰-L-肉碱可用于生化研究和代谢组学研究。
生化/生理作用:月桂酰-L-肉碱是一种酰基肉碱，存在于长链酰基CoA脱氢酶缺乏症、肉碱棕榈酰转移酶Ⅰ缺乏症、肉碱棕榈酰转移酶Ⅱ缺乏症等脂肪酸氧化障碍中。
特点和优势
- 可用于代谢组学和生物化学研究
- 用于多种研究应用的优质化合物
同行评审论文(部分文献)
Targeting Peripheral CB1 Receptors Reduces Ethanol Intake via a Gut-Brain Axis.
Grzegorz Godlewski et al.
Cell metabolism, 29(6), 1320-1333 (2019-05-21)
Endocannabinoids acting on the cannabinoid-1 receptor (CB1R) or ghrelin acting on its receptor (GHS-R1A) both promote alcohol-seeking behavior, but an interaction between the two signaling systems has not been explored. Here, we report that the peripheral CB1R inverse agonist JD5037
The pattern of urinary acylcarnitines determined by electrospray mass spectrometry: a new tool in the diagnosis of diabetes mellitus.
M Möder et al.
Analytical and bioanalytical chemistry, 375(2), 200-210 (2003-02-01)
l-Carnitine and its esters are products of intermediary metabolism of organisms. The distribution pattern or the favored excretion of individual acylcarnitines tells something about metabolic diseases. The determination of the urinary acylcarnitine pattern by flow injection analysis (FIA)-electrospray ionization (ESI)-mass
Mitochondrial very-long-chain acyl-coenzyme A dehydrogenase deficiency: clinical characteristics and diagnostic considerations in 30 patients.
C Vianey-Saban et al.
Clinica chimica acta; international journal of clinical chemistry, 269(1), 43-62 (1998-03-14)
Very-long-chain acyl-CoA dehydrogenase (VLCAD) is an enzyme catalyzing the dehydrogenation of long-chain fatty acids in the first step of mitochondrial fatty acid oxidation. Using an ETF (electron transfer flavoprotein, the physiological electron acceptor of VLCAD) reduction assay, we identified VLCAD
Selective screening for fatty acid oxidation disorders by tandem mass spectrometry: difficulties in practical discrimination.
Yosuke Shigematsu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 792(1), 63-72 (2003-06-28)
In a selective screening for fatty acid oxidation disorders by tandem mass spectrometry, we tested the diagnostic ratios and acylcarnitine concentrations in sera or blood spots, which were reported to be specific to very long-chain acyl CoA dehydrogenase deficiency, carnitine
Isolation of acylcarnitines from urine: a comparison of methods and application to long-chain acyl-CoA dehydrogenase deficiency.
R J Morrow et al.
Clinica chimica acta; international journal of clinical chemistry, 211(1-2), 73-81 (1992-10-15)
Carnitine esters from acetylcarnitine (C2 acyl chain) to octadecanoylcarnitine (C18 acyl chain) can be extracted from urine with recoveries of greater than 80%. However, to obtain such recoveries, it is important to choose the method of extraction appropriate to the
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