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Tocris货号4248-10mg与50mg现货Torin
2上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商- ￥3500.01
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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
Torin 2
- CAS号：
1223001-51-1
- 保质期：
1年
- 保存条件：
2-8°C
- 库存：
30⁺瓶
- 供应商：
上海睿安生物19121878899
- 规格：
10mg/瓶
Tocris货号4248-10mg与50mg现货Torin 2上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商
Description:Potent and selective mTOR inhibitor
Chemical Name:9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
Purity:≥98%
Biological Activity
Torin 2 is a potent and selective mTOR inhibitor(IC50 = 2.1 nM).Displays 800-fold cellular selectivity for mTOR over PI3K(cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively).Activates autophagy.Orally available.Technical Data
M.Wt:432.4
Formula:C24H15F3N4O
Solubility:Soluble to 20 mM in DMSO
Purity:≥98%
Storage:Store at +4°C
CAS No:1223001-51-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Licensing Caveats:
Sold under license from Whitehead Institute for Biomedical Research.
Background References
- Parallel measurement of dynamic changes in translation rates in single cells.
Han, Kyuho, Jaimovich, Ariel, Dey, Gautam, Ruggero, Davide, Meyuhas, Oded, Sonenberg, Nahum, Meyer, Tobias
Nat Methods, 2014;11(1):86-93. - Protein phosphatase 2A isoforms utilizing Abeta scaffolds regulate differentiation through control of Akt protein.
Hwang J, Jiang T, Kulkarni S, Faure N, Schaffhausen B
J Biol Chem, 2013;288(44):32064-73. - Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
Galluzzi et al.
Nat.Rev.Drug.Discov., 2017; - Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.
Liu et al.
J.Med.Chem., 2011;54:1473 - Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation.
Simioni et al.
Oncotarget, 2014;30:10034 - The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABAA receptors in rat glaucoma models
M Ishikawa, S Takaseki, T Yoshitomi, DF Covey, CF Zorumski, Y Izumi
Autophagy, 2020;0(0):1-18.
Citations for Torin 2
The citations listed below are publications that use Tocris products. Selected citations for Torin 2 include:
27 Citations: Showing 1 - 10
- HCN1 channels mediate mu opioid receptor long-term depression at insular cortex inputs to the dorsal striatum.
Authors: Fuqin Et al.
J Physiol 2022;600:4917-4938 - mTORC1 and mTORC2 Complexes Regulate the Untargeted Metabolomics and Amino Acid Metabolites Profile through Mitochondrial Bioenergetic Functions in Pancreatic Beta Cells.
Authors: Rinat R Et al.
Nutrients 2022;14 - RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.
Authors: Steven A Et al.
Nat Commun 2022;13:3181 - Visual barcodes for clonal-multiplexing of live microscopy-based assays.
Authors: Varda Et al.
Nat Commun 2022;13:2725 - Liquid culture system for efficient depletion of the endogenous nutrients in Arabidopsis seedlings.
Authors: Yan Et al.
STAR Protoc 2021;2:100922 - Translation Inhibitors Activate Autophagy Master Regulators TFEB and TFE3.
Authors: Sung Hoon Et al.
Int J Mol Sci 2021;22 - Comparing mTOR inhibitor Rapamycin with Torin-2 within the RIST molecular-targeted regimen in neuroblastoma cells.
Authors: Selim Et al.
Int J Med Sci 2021;18:137-149 - The Synergistic Effect of an ATP-Competitive Inhibitor of mTOR and Metformin on Pancreatic Tumor Growth.
Authors: Pankaj K Et al.
Curr Dev Nutr 2020;4:nzaa131 - Advances in respiratory virus therapeutics - A meeting report from the 6th isirv Antiviral Group conference.
Authors: Amy C Et al.
Antiviral Res 2019;167:45-67 - Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity.
Authors: Ginzberg Et al.
Elife 2018;7
Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL.
Authors: Feehan Et al.
Cell Signal 2018;52:35
Direct Targeting of the mTOR (Mammalian Target of Rapamycin) Kinase Improves Endothelial Permeability in Drug-Eluting Stents-Brief Report.
Authors: Harari Et al.
Arterioscler Thromb Vasc Biol 2018;38:2217
SYK kinase mediates brown fat differentiation and activation.
Authors: Lei Et al.
Nat Commun 2017;8:2115
Effects of MET and a Mammalian Target of Rapamycin (mTOR) ATP-Competitive Inhibitor on Targeted Metabolomics in Pancreatic Cancer Cell Line.
Authors: Soliman Et al.
Metabolomics (Los Angel) 2017;6
The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury.
Authors: Al-Ali Et al.
J Neurosci 2017;37:7079
Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas.
Authors: Jennewein Et al.
Oncotarget 2016;7:20016
PI3K/mTORC2 regulates TGF-β/AVNsignalling by modulating Smad2/3 activity via linker phosphorylation.
Authors: Yu Et al.
BMC Biochem 2015;6:7212
Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors.
Authors: Markus A Et al.
Carcinogenesis 2015;36:487-97
Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium.
Authors: Toops Et al.
Nat Commun 2015;26:41640
Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of cisp. in Epithelial Ovarian Cancer.
Authors: Hussain Et al.
Mol Med 2015;21:466
Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.
Authors: Brown Et al.
Mol Biol Cell 2014;88:13149
High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma.
Authors: Ahmed Et al.
Carcinogenesis 2014;35:1564
mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading.
Authors: Martin Et al.
Am J Physiol Endocrinol Metab 2014;306:E1397
Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages.
Authors: Zullo Et al.
Cell 2014;15:4
Parallel measurement of dynamic changes in translation rates in single cells.
Authors: Han Et al.
Nat Methods 2014;11:86
ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
Authors: Montané and Menand
J Virol 2013;64:4361
Protein phosphatase 2A isoforms utilizing Aβ scaffolds regulate differentiation through control of Akt protein.
Authors: Hwang Et al.
J Biol Chem 2013;288:32064
Authors: Feehan Et al.
Cell Signal 2018;52:35
Direct Targeting of the mTOR (Mammalian Target of Rapamycin) Kinase Improves Endothelial Permeability in Drug-Eluting Stents-Brief Report.
Authors: Harari Et al.
Arterioscler Thromb Vasc Biol 2018;38:2217
SYK kinase mediates brown fat differentiation and activation.
Authors: Lei Et al.
Nat Commun 2017;8:2115
Effects of MET and a Mammalian Target of Rapamycin (mTOR) ATP-Competitive Inhibitor on Targeted Metabolomics in Pancreatic Cancer Cell Line.
Authors: Soliman Et al.
Metabolomics (Los Angel) 2017;6
The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury.
Authors: Al-Ali Et al.
J Neurosci 2017;37:7079
Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas.
Authors: Jennewein Et al.
Oncotarget 2016;7:20016
PI3K/mTORC2 regulates TGF-β/AVNsignalling by modulating Smad2/3 activity via linker phosphorylation.
Authors: Yu Et al.
BMC Biochem 2015;6:7212
Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors.
Authors: Markus A Et al.
Carcinogenesis 2015;36:487-97
Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium.
Authors: Toops Et al.
Nat Commun 2015;26:41640
Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of cisp. in Epithelial Ovarian Cancer.
Authors: Hussain Et al.
Mol Med 2015;21:466
Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.
Authors: Brown Et al.
Mol Biol Cell 2014;88:13149
High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma.
Authors: Ahmed Et al.
Carcinogenesis 2014;35:1564
mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading.
Authors: Martin Et al.
Am J Physiol Endocrinol Metab 2014;306:E1397
Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages.
Authors: Zullo Et al.
Cell 2014;15:4
Parallel measurement of dynamic changes in translation rates in single cells.
Authors: Han Et al.
Nat Methods 2014;11:86
ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
Authors: Montané and Menand
J Virol 2013;64:4361
Protein phosphatase 2A isoforms utilizing Aβ scaffolds regulate differentiation through control of Akt protein.
Authors: Hwang Et al.
J Biol Chem 2013;288:32064
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文献和实验该产品被引用文献
Tocris货号4248-10mg与50mg现货Torin 2上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商
Description:Potent and selective mTOR inhibitor
Chemical Name:9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
Purity:≥98%
Biological Activity
Torin 2 is a potent and selective mTOR inhibitor(IC50 = 2.1 nM).Displays 800-fold cellular selectivity for mTOR over PI3K(cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively).Activates autophagy.Orally available.Technical Data
M.Wt:432.4
Formula:C24H15F3N4O
Solubility:Soluble to 20 mM in DMSO
Purity:≥98%
Storage:Store at +4°C
CAS No:1223001-51-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Licensing Caveats:
Sold under license from Whitehead Institute for Biomedical Research.
Background References
- Parallel measurement of dynamic changes in translation rates in single cells.
Han, Kyuho, Jaimovich, Ariel, Dey, Gautam, Ruggero, Davide, Meyuhas, Oded, Sonenberg, Nahum, Meyer, Tobias
Nat Methods, 2014;11(1):86-93. - Protein phosphatase 2A isoforms utilizing Abeta scaffolds regulate differentiation through control of Akt protein.
Hwang J, Jiang T, Kulkarni S, Faure N, Schaffhausen B
J Biol Chem, 2013;288(44):32064-73. - Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
Galluzzi et al.
Nat.Rev.Drug.Discov., 2017; - Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.
Liu et al.
J.Med.Chem., 2011;54:1473 - Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation.
Simioni et al.
Oncotarget, 2014;30:10034 - The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABAA receptors in rat glaucoma models
M Ishikawa, S Takaseki, T Yoshitomi, DF Covey, CF Zorumski, Y Izumi
Autophagy, 2020;0(0):1-18.
Citations for Torin 2
The citations listed below are publications that use Tocris products. Selected citations for Torin 2 include:
27 Citations: Showing 1 - 10
- HCN1 channels mediate mu opioid receptor long-term depression at insular cortex inputs to the dorsal striatum.
Authors: Fuqin Et al.
J Physiol 2022;600:4917-4938 - mTORC1 and mTORC2 Complexes Regulate the Untargeted Metabolomics and Amino Acid Metabolites Profile through Mitochondrial Bioenergetic Functions in Pancreatic Beta Cells.
Authors: Rinat R Et al.
Nutrients 2022;14 - RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.
Authors: Steven A Et al.
Nat Commun 2022;13:3181 - Visual barcodes for clonal-multiplexing of live microscopy-based assays.
Authors: Varda Et al.
Nat Commun 2022;13:2725 - Liquid culture system for efficient depletion of the endogenous nutrients in Arabidopsis seedlings.
Authors: Yan Et al.
STAR Protoc 2021;2:100922 - Translation Inhibitors Activate Autophagy Master Regulators TFEB and TFE3.
Authors: Sung Hoon Et al.
Int J Mol Sci 2021;22 - Comparing mTOR inhibitor Rapamycin with Torin-2 within the RIST molecular-targeted regimen in neuroblastoma cells.
Authors: Selim Et al.
Int J Med Sci 2021;18:137-149 - The Synergistic Effect of an ATP-Competitive Inhibitor of mTOR and Metformin on Pancreatic Tumor Growth.
Authors: Pankaj K Et al.
Curr Dev Nutr 2020;4:nzaa131 - Advances in respiratory virus therapeutics - A meeting report from the 6th isirv Antiviral Group conference.
Authors: Amy C Et al.
Antiviral Res 2019;167:45-67 - Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity.
Authors: Ginzberg Et al.
Elife 2018;7
Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL.
Authors: Feehan Et al.
Cell Signal 2018;52:35
Direct Targeting of the mTOR (Mammalian Target of Rapamycin) Kinase Improves Endothelial Permeability in Drug-Eluting Stents-Brief Report.
Authors: Harari Et al.
Arterioscler Thromb Vasc Biol 2018;38:2217
SYK kinase mediates brown fat differentiation and activation.
Authors: Lei Et al.
Nat Commun 2017;8:2115
Effects of MET and a Mammalian Target of Rapamycin (mTOR) ATP-Competitive Inhibitor on Targeted Metabolomics in Pancreatic Cancer Cell Line.
Authors: Soliman Et al.
Metabolomics (Los Angel) 2017;6
The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury.
Authors: Al-Ali Et al.
J Neurosci 2017;37:7079
Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas.
Authors: Jennewein Et al.
Oncotarget 2016;7:20016
PI3K/mTORC2 regulates TGF-β/AVNsignalling by modulating Smad2/3 activity via linker phosphorylation.
Authors: Yu Et al.
BMC Biochem 2015;6:7212
Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors.
Authors: Markus A Et al.
Carcinogenesis 2015;36:487-97
Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium.
Authors: Toops Et al.
Nat Commun 2015;26:41640
Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of cisp. in Epithelial Ovarian Cancer.
Authors: Hussain Et al.
Mol Med 2015;21:466
Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.
Authors: Brown Et al.
Mol Biol Cell 2014;88:13149
High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma.
Authors: Ahmed Et al.
Carcinogenesis 2014;35:1564
mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading.
Authors: Martin Et al.
Am J Physiol Endocrinol Metab 2014;306:E1397
Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages.
Authors: Zullo Et al.
Cell 2014;15:4
Parallel measurement of dynamic changes in translation rates in single cells.
Authors: Han Et al.
Nat Methods 2014;11:86
ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
Authors: Montané and Menand
J Virol 2013;64:4361
Protein phosphatase 2A isoforms utilizing Aβ scaffolds regulate differentiation through control of Akt protein.
Authors: Hwang Et al.
J Biol Chem 2013;288:32064
Authors: Feehan Et al.
Cell Signal 2018;52:35
Direct Targeting of the mTOR (Mammalian Target of Rapamycin) Kinase Improves Endothelial Permeability in Drug-Eluting Stents-Brief Report.
Authors: Harari Et al.
Arterioscler Thromb Vasc Biol 2018;38:2217
SYK kinase mediates brown fat differentiation and activation.
Authors: Lei Et al.
Nat Commun 2017;8:2115
Effects of MET and a Mammalian Target of Rapamycin (mTOR) ATP-Competitive Inhibitor on Targeted Metabolomics in Pancreatic Cancer Cell Line.
Authors: Soliman Et al.
Metabolomics (Los Angel) 2017;6
The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury.
Authors: Al-Ali Et al.
J Neurosci 2017;37:7079
Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas.
Authors: Jennewein Et al.
Oncotarget 2016;7:20016
PI3K/mTORC2 regulates TGF-β/AVNsignalling by modulating Smad2/3 activity via linker phosphorylation.
Authors: Yu Et al.
BMC Biochem 2015;6:7212
Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors.
Authors: Markus A Et al.
Carcinogenesis 2015;36:487-97
Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium.
Authors: Toops Et al.
Nat Commun 2015;26:41640
Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of cisp. in Epithelial Ovarian Cancer.
Authors: Hussain Et al.
Mol Med 2015;21:466
Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.
Authors: Brown Et al.
Mol Biol Cell 2014;88:13149
High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma.
Authors: Ahmed Et al.
Carcinogenesis 2014;35:1564
mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading.
Authors: Martin Et al.
Am J Physiol Endocrinol Metab 2014;306:E1397
Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages.
Authors: Zullo Et al.
Cell 2014;15:4
Parallel measurement of dynamic changes in translation rates in single cells.
Authors: Han Et al.
Nat Methods 2014;11:86
ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
Authors: Montané and Menand
J Virol 2013;64:4361
Protein phosphatase 2A isoforms utilizing Aβ scaffolds regulate differentiation through control of Akt protein.
Authors: Hwang Et al.
J Biol Chem 2013;288:32064
文献支持
Tocris货号4248-10mg与50mg现货Torin 2上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商
￥3500.01
