Erythropoietin R/EPOR重组蛋白|Recombinant Human EPO Receptor / EPOR Protein (ECD, His Tag)
- ￥2310 - 25190
- Sino Biological
- 北京
- 10707-H08H
- 2026年01月23日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20℃ to -80℃
- 保质期：
12个月
- 英文名：
Recombinant Human EPO Receptor / EPOR Protein (ECD, His Tag)
- 库存：
99
- 供应商：
北京义翘神州科技股份有限公司
- 规格：
1.00 mg/50.00 µg/100.00 µg
| 规格： | 1.00 mg | 产品价格： | ￥25190.0 |
|---|---|---|---|
| 规格： | 50.00 µg | 产品价格： | ￥2310.0 |
| 规格： | 100.00 µg | 产品价格： | ￥3870.0 |
蛋白名称：Human EPO Receptor / EPOR Protein (ECD, His Tag)
蛋白构建：A DNA sequence encoding the extracellular domain (Met 1-Pro 250) of human erythropoietin receptor (NP_000112.1) precursor was fused with a polyhistidine tag at the C-terminus.
表达宿主：HEK293 Cells
蛋白纯度：> 98 % as determined by SDS-PAGE
蛋白活性：Measured by its ability to inhibit EPO-dependent proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is typically 15-60 ng/mL in the presence of 0.1 U/mL Recombinant Human EPO.
蛋白内毒素：< 1.0 EU per μg of the protein as determined by the LAL method
预测N端：Ala 25
蛋白分子量：The secreted recombinant human EPOR consists of 237 amino acids and has a predicted molecular mass of 26.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhEPOR is approximately 34 kDa due to glycosylation.
蛋白NP号：NP_000112.1
蛋白氨基酸序列：Met1-Pro250
蛋白标签：C-His
蛋白保存条件：Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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文献和实验2, Liu, L; et al. Method Development of Pegmolesatide for Doping Analysis: A Novel Synthetic Erythropoietin-Mimetic Agent. Drug testing and analysis, PMID: 40675650
3, Adams, JJ; et al. An asymmetric tetrabody is a potent and efficacious agonist of the erythropoietin receptor in vitro and in vivo. Protein science : a publication of the Protein Society, PMID: 40960423
Epo and Non-hematopoietic Cells: What Do We Know
with targeted deletion of Epo or the Epo receptor (EpoR) show impaired erythropoiesis, lack mature erythrocytes, and die in utero around embryonic day 13.5 (Wu et al. Cell 83:59–67, 1995; Lin et al. Genes Dev. 10:154–164, 1996
请教一个弱智的问题, 帮忙把genebank上查的report逐个解释一下, 不要遗漏信息!
LOCUS NM_017002 1524 bp mRNA linear ROD 28-OCT-2004 DEFINITION Rattus norvegicus erythropoietin receptor (Epor), mRNA. ACCESSION NM_017002 VERSION NM_017002.1 GI:8393318 KEYWORDS . SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus
生成素（erythropoietin,EPO）受体胞膜外区体在氨基酸序列上有较高的同源性，分子结构上也有较大的相似性，故得名。 （1）ERS的成员：属于ERS的成员有EPOR、血小板生成素R、IL-2β链（CD122）、IL-2Rγ链、IL-3Rα链（CD123）、IL-3Rβ、IIL-4R（CDw124）、IL-5Rα链、IL-5βα链、IL-5Rβ链、IL-6Rα链（CD126）、gp130(CDw123)、IL-7R、IL-9R、IL-11R、IL-1240kDa亚单位、G-CSFR、GM-CSFRα链、GM
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