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Tocris货号3509现货BMS 493上海睿安生物R&D

Systems-Tocris官方正式授权代理19121878899
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  • ¥3640.01
  • Tocris bioscience
  • 3509
  • made in USA
  • 2025年12月17日
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    • 文献和实验
    • 技术资料
    • 英文名

      BMS 493

    • CAS号

      215030-90-3

    • 保质期

      1年

    • 保存条件

      2-8°C

    • 库存

      30⁺瓶

    • 供应商

      上海睿安生物19121878899

    • 规格

      10mg/瓶

    Tocris货号3509-10mg现货BMS 493上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899

     

    Tocris货号3509-50mg现货BMS 493上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899

    Description:Pan-RAR inverse agonist

    Chemical Name:4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoic acid

    Purity:≥98%

    Biological Activity

    BMS 493 is a pan-retinoic acid receptor (pan-RAR) inverse agonist. Enhances nuclear corepressor (NCoR) interaction with RARs. Binding induces analogous conformational changes in all RAR types (RARα, RARβ and RARγ).

    Technical Data

    M.Wt:404.5
    Formula:C29H24O2
    Solubility:Soluble to 100 mM in DMSO
    Purity:≥98%
    Storage:Store at +4°C
    CAS No:215030-90-3

    The technical data provided above is for guidance only.For batch specific data refer to the Certificate of Analysis.
    Tocris products are intended for laboratory research use only,unless stated otherwise.

     

    Background References

    1. Anti-inflammatory effects of minocycline are mediated by retinoid signaling
      V Clemens, F Regen, N Le Bret, I Heuser, J Hellmann-R
      BMC Neurosci, 2018;19(1):58.
    2. Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.
      Raverdeau M, Gely-Pernot A, Feret B, Dennefeld C, Benoit G, Davidson I, Chambon P, Mark M, Ghyselinck N
      Proc Natl Acad Sci U S A, 2012;109(41):16582-7.
    3. Anti-inflammatory effects of minocycline are mediated by retinoid signaling
      V Clemens, F Regen, N Le Bret, I Heuser, J Hellmann-R
      BMC Neurosci, 2018;19(1):58.
    4. Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation
      JP Ng-Blichfe, A Schrik, RK Kortekaas, JA Noordhoek, IH Heijink, PS Hiemstra, J Stolk, M Königshoff, R Gosens
      EBioMedicine, 2018;36(0):461-474.
    5. Higher-Order Kidney Organogenesis from Pluripotent Stem Cells
      A Taguchi, R Nishinakam
      Cell Stem Cell, 2017;0(0):.
    6. Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells
      F Pei, J Jiang, S Bai, H Cao, L Tian, Y Zhao, C Yang, H Dong, Y Ma
      Stem Cell Res, 2017;19(0):94-103.
    7. Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea.
      Thiede B, Mann Z, Chang W, Ku Y, Son Y, Lovett M, Kelley M, Corwin J
      Nat Commun, 2014;5(0):3840.
    8. Systemic bud induction and retinioic acid signaling underlie whole body regeneration in the urochordate Botrylloides leachi.
      Rinkevich et al.
      PLoS Biology., 2007;5:e71
    9. Differential action on coregulator interaction defines retinoid agonists and neutral antagonists.
      Germain et al.
      Chem.Biol., 2009;16:479
    10. Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection.
      Christoph Wilhelm, Oliver J Harrison, Vanessa Schmitt, Martin Pelletier, Sean P Spencer, Joseph F Urban, Michelle Ploch, Thirumalai R Ramalinga, Richard M Siegel, Yasmine Belkaid
      The Journal of Experimental Medicine, 2016;0(0):1540-9538.

    Citations for BMS 493(部分:文献)

    The citations listed below are publications that use Tocris products. Selected citations for BMS 493 include:

    29 Citations: Showing 1 - 10

    1.  Retinoic acid inhibitors mitigate vision loss in a mouse model of retinal degeneration.
      Authors: Richard H Et al.
      Sci Adv  2022;8:eabm4643
    2.  Tenogenic Induction From Induced Pluripotent Stem Cells Unveils the Trajectory Towards Tenocyte Differentiation.
      Authors: Yasuyuki Et al.
      Front Cell Dev Biol  2022;10:780038
    3.  Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency.
      Authors: Jennifer Et al.
      Cell Stem Cell  2021;28:453-471.e8
    4.  Retinoic acid signaling is directly activated in cardiomyocytes and protects mouse hearts from apoptosis after myocardial infarction.
      Authors: Norbert B Et al.
      Elife  2021;10
    5.  Retinoic acid signalling in fibro/adipogenic progenitors robustly enhances muscle regeneration.
      Authors: Min Et al.
      EBioMedicine  2020;60:103020
    6.  Retinoic Acid Signal Negatively Regulates Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells.
      Authors: Jinsong Et al.
      Stem Cells Int  2020;2020:5891783
    7.  Local retinoic acid signaling directs emergence of the extraocular muscle functional unit.
      Authors: Comai Et al.
      PLoS Biol.  2020;18:e3000902
    8.  Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression.
      Authors: M Celeste Et al.
      Cell  2020;180:1098-1114.e16
    9.  A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages.
      Authors: Wendy Et al.
      Immunity  2019;51:119-130.e5
    10.  A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult.
      Authors: Tim Et al.
      Immunity  2019;50:1276-1288.e5
     Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin.
    Authors: Kelly A Et al.
    Cell Host Microbe  2019;25:777-788.e8
     Delayed onset of smooth muscle cell differentiation leads to hydroureter formation in mice with conditional loss of the zinc finger transcription factor gene Gata2 in the ureteric mesenchyme.
    Authors: Rannar Et al.
    J Pathol  2019;248:452-463
     Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression.
    Authors: Cordeiro Et al.
    Structure  2019;
     Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation.
    Authors: Ng-Blichfeldt Et al.
    EBioMedicine  2018;36:461
     RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation.
    Authors: Metzler Et al.
    Development  2018;145
     Retinoic acid signaling maintains epithelial and mesenchymal progenitors in the developing mouse ureter.
    Authors: Bohnenpoll
    Sci Rep  2017;7(1):14803
     A Gene Regulatory Network Balances Neural and Mesoderm Specification during Vertebrate Trunk Development.
    Authors: James Et al.
    Dev Cell  2017;41:243-261.e7
     Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+adipose progenitors.
    Authors: Wang Et al.
    Cell Discov  2017;3:17036
     Retinoic acid signaling regulates Krt5 and Krt14 independently of stem cell markers in submandibular salivary gland epithelium.
    Authors: Abashev Et al.
    Dev Dyn  2017;246:135
     Higher-Order Kidney Organogenesis from Pluripotent Stem Cells.
    Authors: Ryuichi Et al.
    Cell Stem Cell  2017;21:730-746.e6
     Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells.
    Authors: Pei Et al.
    Stem Cell Res  2017;19:94
     Maternal Retinoids Increase PDGFRα+ Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development.
    Authors: Wang Et al.
    EBioMedicine  2017;18:288
     Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell- Mediated Immunity in Colorectal Cancer
    Authors: Bhattacharya Et al.
    Immunity  2016;45:1
     Retinoic acid regulates embryonic development of mammalian submandibular salivary glands.
    Authors: Lisa L Et al.
    Dev Biol  2015;407:57-67
     Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea.
    Authors: Thiede Et al.
    Nat Commun  2014;5:3840
     Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity.
    Authors: Pavert Et al.
    Nature  2014;508:123
     Retinoic acid receptor alpha is associated with tamox. resistance in breast cancer.
    Authors: Johansson Et al.
    Nat Commun  2013;4:2175
     Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus.
    Authors: Rankin Et al.
    J Biol Chem  2012;139:3010
     Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.
    Authors: Raverdeau Et al.
    Proc Natl Acad Sci U S A  2012;109:16582

      产品细节图片1产品细节图片2产品细节图片3产品细节图片4

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      图标文献和实验
      该产品被引用文献

      Tocris货号3509-10mg现货BMS 493上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899

       

      Tocris货号3509-50mg现货BMS 493上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899

      Description:Pan-RAR inverse agonist

      Chemical Name:4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoic acid

      Purity:≥98%

      Biological Activity

      BMS 493 is a pan-retinoic acid receptor (pan-RAR) inverse agonist. Enhances nuclear corepressor (NCoR) interaction with RARs. Binding induces analogous conformational changes in all RAR types (RARα, RARβ and RARγ).

      Technical Data

      M.Wt:404.5
      Formula:C29H24O2
      Solubility:Soluble to 100 mM in DMSO
      Purity:≥98%
      Storage:Store at +4°C
      CAS No:215030-90-3

      The technical data provided above is for guidance only.For batch specific data refer to the Certificate of Analysis.
      Tocris products are intended for laboratory research use only,unless stated otherwise.

       

      Background References

      1. Anti-inflammatory effects of minocycline are mediated by retinoid signaling
        V Clemens, F Regen, N Le Bret, I Heuser, J Hellmann-R
        BMC Neurosci, 2018;19(1):58.
      2. Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.
        Raverdeau M, Gely-Pernot A, Feret B, Dennefeld C, Benoit G, Davidson I, Chambon P, Mark M, Ghyselinck N
        Proc Natl Acad Sci U S A, 2012;109(41):16582-7.
      3. Anti-inflammatory effects of minocycline are mediated by retinoid signaling
        V Clemens, F Regen, N Le Bret, I Heuser, J Hellmann-R
        BMC Neurosci, 2018;19(1):58.
      4. Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation
        JP Ng-Blichfe, A Schrik, RK Kortekaas, JA Noordhoek, IH Heijink, PS Hiemstra, J Stolk, M Königshoff, R Gosens
        EBioMedicine, 2018;36(0):461-474.
      5. Higher-Order Kidney Organogenesis from Pluripotent Stem Cells
        A Taguchi, R Nishinakam
        Cell Stem Cell, 2017;0(0):.
      6. Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells
        F Pei, J Jiang, S Bai, H Cao, L Tian, Y Zhao, C Yang, H Dong, Y Ma
        Stem Cell Res, 2017;19(0):94-103.
      7. Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea.
        Thiede B, Mann Z, Chang W, Ku Y, Son Y, Lovett M, Kelley M, Corwin J
        Nat Commun, 2014;5(0):3840.
      8. Systemic bud induction and retinioic acid signaling underlie whole body regeneration in the urochordate Botrylloides leachi.
        Rinkevich et al.
        PLoS Biology., 2007;5:e71
      9. Differential action on coregulator interaction defines retinoid agonists and neutral antagonists.
        Germain et al.
        Chem.Biol., 2009;16:479
      10. Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection.
        Christoph Wilhelm, Oliver J Harrison, Vanessa Schmitt, Martin Pelletier, Sean P Spencer, Joseph F Urban, Michelle Ploch, Thirumalai R Ramalinga, Richard M Siegel, Yasmine Belkaid
        The Journal of Experimental Medicine, 2016;0(0):1540-9538.

      Citations for BMS 493(部分:文献)

      The citations listed below are publications that use Tocris products. Selected citations for BMS 493 include:

      29 Citations: Showing 1 - 10

      1.  Retinoic acid inhibitors mitigate vision loss in a mouse model of retinal degeneration.
        Authors: Richard H Et al.
        Sci Adv  2022;8:eabm4643
      2.  Tenogenic Induction From Induced Pluripotent Stem Cells Unveils the Trajectory Towards Tenocyte Differentiation.
        Authors: Yasuyuki Et al.
        Front Cell Dev Biol  2022;10:780038
      3.  Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency.
        Authors: Jennifer Et al.
        Cell Stem Cell  2021;28:453-471.e8
      4.  Retinoic acid signaling is directly activated in cardiomyocytes and protects mouse hearts from apoptosis after myocardial infarction.
        Authors: Norbert B Et al.
        Elife  2021;10
      5.  Retinoic acid signalling in fibro/adipogenic progenitors robustly enhances muscle regeneration.
        Authors: Min Et al.
        EBioMedicine  2020;60:103020
      6.  Retinoic Acid Signal Negatively Regulates Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells.
        Authors: Jinsong Et al.
        Stem Cells Int  2020;2020:5891783
      7.  Local retinoic acid signaling directs emergence of the extraocular muscle functional unit.
        Authors: Comai Et al.
        PLoS Biol.  2020;18:e3000902
      8.  Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression.
        Authors: M Celeste Et al.
        Cell  2020;180:1098-1114.e16
      9.  A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages.
        Authors: Wendy Et al.
        Immunity  2019;51:119-130.e5
      10.  A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult.
        Authors: Tim Et al.
        Immunity  2019;50:1276-1288.e5
       Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin.
      Authors: Kelly A Et al.
      Cell Host Microbe  2019;25:777-788.e8
       Delayed onset of smooth muscle cell differentiation leads to hydroureter formation in mice with conditional loss of the zinc finger transcription factor gene Gata2 in the ureteric mesenchyme.
      Authors: Rannar Et al.
      J Pathol  2019;248:452-463
       Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression.
      Authors: Cordeiro Et al.
      Structure  2019;
       Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation.
      Authors: Ng-Blichfeldt Et al.
      EBioMedicine  2018;36:461
       RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation.
      Authors: Metzler Et al.
      Development  2018;145
       Retinoic acid signaling maintains epithelial and mesenchymal progenitors in the developing mouse ureter.
      Authors: Bohnenpoll
      Sci Rep  2017;7(1):14803
       A Gene Regulatory Network Balances Neural and Mesoderm Specification during Vertebrate Trunk Development.
      Authors: James Et al.
      Dev Cell  2017;41:243-261.e7
       Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+adipose progenitors.
      Authors: Wang Et al.
      Cell Discov  2017;3:17036
       Retinoic acid signaling regulates Krt5 and Krt14 independently of stem cell markers in submandibular salivary gland epithelium.
      Authors: Abashev Et al.
      Dev Dyn  2017;246:135
       Higher-Order Kidney Organogenesis from Pluripotent Stem Cells.
      Authors: Ryuichi Et al.
      Cell Stem Cell  2017;21:730-746.e6
       Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells.
      Authors: Pei Et al.
      Stem Cell Res  2017;19:94
       Maternal Retinoids Increase PDGFRα+ Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development.
      Authors: Wang Et al.
      EBioMedicine  2017;18:288
       Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell- Mediated Immunity in Colorectal Cancer
      Authors: Bhattacharya Et al.
      Immunity  2016;45:1
       Retinoic acid regulates embryonic development of mammalian submandibular salivary glands.
      Authors: Lisa L Et al.
      Dev Biol  2015;407:57-67
       Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea.
      Authors: Thiede Et al.
      Nat Commun  2014;5:3840
       Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity.
      Authors: Pavert Et al.
      Nature  2014;508:123
       Retinoic acid receptor alpha is associated with tamox. resistance in breast cancer.
      Authors: Johansson Et al.
      Nat Commun  2013;4:2175
       Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus.
      Authors: Rankin Et al.
      J Biol Chem  2012;139:3010
       Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.
      Authors: Raverdeau Et al.
      Proc Natl Acad Sci U S A  2012;109:16582

        引用文献图片1引用文献图片2引用文献图片3引用文献图片4

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        Tocris货号3509现货BMS 493上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899
        ¥3640.01