相关产品推荐更多 >

Tocris货号1465-1mg现货Rat Ghrelin上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899
¥8134.01
Sigma货号MAK307-1KT孔雀绿磷酸盐检测试剂盒13611631389上海睿安生物
¥3244.47
Sigma货号N2752-1g现货4-硝(xiāo)基苯棕榈酸酯13611631389上海睿安生物
¥496
Sigma货号E4378-250g现货EGTA乙二醇双(2-氨基乙基醚)四乙酸19121878899上海睿安生物
¥3963.03
Biodragon博奥龙KX0110041现货QuickShuttle-Basic基础型QuickShuttle转染试剂13611631389上海睿安生物
¥840.01
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 英文名:
BMS 493
- CAS号:
215030-90-3
- 保质期:
1年
- 保存条件:
2-8°C
- 库存:
30⁺瓶
- 供应商:
上海睿安生物19121878899
- 规格:
10mg/瓶
Tocris货号3509-10mg现货BMS 493上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899
Tocris货号3509-50mg现货BMS 493上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899
Chemical Name:4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoic acid
Purity:≥98%
Biological Activity
BMS 493 is a pan-retinoic acid receptor (pan-RAR) inverse agonist. Enhances nuclear corepressor (NCoR) interaction with RARs. Binding induces analogous conformational changes in all RAR types (RARα, RARβ and RARγ).Technical Data
The technical data provided above is for guidance only.For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only,unless stated otherwise.
Background References
- Anti-inflammatory effects of minocycline are mediated by retinoid signaling
V Clemens, F Regen, N Le Bret, I Heuser, J Hellmann-R
BMC Neurosci, 2018;19(1):58. - Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.
Raverdeau M, Gely-Pernot A, Feret B, Dennefeld C, Benoit G, Davidson I, Chambon P, Mark M, Ghyselinck N
Proc Natl Acad Sci U S A, 2012;109(41):16582-7. - Anti-inflammatory effects of minocycline are mediated by retinoid signaling
V Clemens, F Regen, N Le Bret, I Heuser, J Hellmann-R
BMC Neurosci, 2018;19(1):58. - Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation
JP Ng-Blichfe, A Schrik, RK Kortekaas, JA Noordhoek, IH Heijink, PS Hiemstra, J Stolk, M Königshoff, R Gosens
EBioMedicine, 2018;36(0):461-474. - Higher-Order Kidney Organogenesis from Pluripotent Stem Cells
A Taguchi, R Nishinakam
Cell Stem Cell, 2017;0(0):. - Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells
F Pei, J Jiang, S Bai, H Cao, L Tian, Y Zhao, C Yang, H Dong, Y Ma
Stem Cell Res, 2017;19(0):94-103. - Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea.
Thiede B, Mann Z, Chang W, Ku Y, Son Y, Lovett M, Kelley M, Corwin J
Nat Commun, 2014;5(0):3840. - Systemic bud induction and retinioic acid signaling underlie whole body regeneration in the urochordate Botrylloides leachi.
Rinkevich et al.
PLoS Biology., 2007;5:e71 - Differential action on coregulator interaction defines retinoid agonists and neutral antagonists.
Germain et al.
Chem.Biol., 2009;16:479 - Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection.
Christoph Wilhelm, Oliver J Harrison, Vanessa Schmitt, Martin Pelletier, Sean P Spencer, Joseph F Urban, Michelle Ploch, Thirumalai R Ramalinga, Richard M Siegel, Yasmine Belkaid
The Journal of Experimental Medicine, 2016;0(0):1540-9538.
Citations for BMS 493(部分:文献)
The citations listed below are publications that use Tocris products. Selected citations for BMS 493 include:
29 Citations: Showing 1 - 10
- Retinoic acid inhibitors mitigate vision loss in a mouse model of retinal degeneration.
Authors: Richard H Et al.
Sci Adv 2022;8:eabm4643 - Tenogenic Induction From Induced Pluripotent Stem Cells Unveils the Trajectory Towards Tenocyte Differentiation.
Authors: Yasuyuki Et al.
Front Cell Dev Biol 2022;10:780038 - Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency.
Authors: Jennifer Et al.
Cell Stem Cell 2021;28:453-471.e8 - Retinoic acid signaling is directly activated in cardiomyocytes and protects mouse hearts from apoptosis after myocardial infarction.
Authors: Norbert B Et al.
Elife 2021;10 - Retinoic acid signalling in fibro/adipogenic progenitors robustly enhances muscle regeneration.
Authors: Min Et al.
EBioMedicine 2020;60:103020 - Retinoic Acid Signal Negatively Regulates Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells.
Authors: Jinsong Et al.
Stem Cells Int 2020;2020:5891783 - Local retinoic acid signaling directs emergence of the extraocular muscle functional unit.
Authors: Comai Et al.
PLoS Biol. 2020;18:e3000902 - Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression.
Authors: M Celeste Et al.
Cell 2020;180:1098-1114.e16 - A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages.
Authors: Wendy Et al.
Immunity 2019;51:119-130.e5 - A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult.
Authors: Tim Et al.
Immunity 2019;50:1276-1288.e5
Authors: Kelly A Et al.
Cell Host Microbe 2019;25:777-788.e8
Delayed onset of smooth muscle cell differentiation leads to hydroureter formation in mice with conditional loss of the zinc finger transcription factor gene Gata2 in the ureteric mesenchyme.
Authors: Rannar Et al.
J Pathol 2019;248:452-463
Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression.
Authors: Cordeiro Et al.
Structure 2019;
Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation.
Authors: Ng-Blichfeldt Et al.
EBioMedicine 2018;36:461
RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation.
Authors: Metzler Et al.
Development 2018;145
Retinoic acid signaling maintains epithelial and mesenchymal progenitors in the developing mouse ureter.
Authors: Bohnenpoll
Sci Rep 2017;7(1):14803
A Gene Regulatory Network Balances Neural and Mesoderm Specification during Vertebrate Trunk Development.
Authors: James Et al.
Dev Cell 2017;41:243-261.e7
Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+adipose progenitors.
Authors: Wang Et al.
Cell Discov 2017;3:17036
Retinoic acid signaling regulates Krt5 and Krt14 independently of stem cell markers in submandibular salivary gland epithelium.
Authors: Abashev Et al.
Dev Dyn 2017;246:135
Higher-Order Kidney Organogenesis from Pluripotent Stem Cells.
Authors: Ryuichi Et al.
Cell Stem Cell 2017;21:730-746.e6
Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells.
Authors: Pei Et al.
Stem Cell Res 2017;19:94
Maternal Retinoids Increase PDGFRα+ Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development.
Authors: Wang Et al.
EBioMedicine 2017;18:288
Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell- Mediated Immunity in Colorectal Cancer
Authors: Bhattacharya Et al.
Immunity 2016;45:1
Retinoic acid regulates embryonic development of mammalian submandibular salivary glands.
Authors: Lisa L Et al.
Dev Biol 2015;407:57-67
Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea.
Authors: Thiede Et al.
Nat Commun 2014;5:3840
Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity.
Authors: Pavert Et al.
Nature 2014;508:123
Retinoic acid receptor alpha is associated with tamox. resistance in breast cancer.
Authors: Johansson Et al.
Nat Commun 2013;4:2175
Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus.
Authors: Rankin Et al.
J Biol Chem 2012;139:3010
Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.
Authors: Raverdeau Et al.
Proc Natl Acad Sci U S A 2012;109:16582




风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Tocris货号3509-10mg现货BMS 493上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899
Tocris货号3509-50mg现货BMS 493上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899
Chemical Name:4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoic acid
Purity:≥98%
Biological Activity
BMS 493 is a pan-retinoic acid receptor (pan-RAR) inverse agonist. Enhances nuclear corepressor (NCoR) interaction with RARs. Binding induces analogous conformational changes in all RAR types (RARα, RARβ and RARγ).Technical Data
The technical data provided above is for guidance only.For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only,unless stated otherwise.
Background References
- Anti-inflammatory effects of minocycline are mediated by retinoid signaling
V Clemens, F Regen, N Le Bret, I Heuser, J Hellmann-R
BMC Neurosci, 2018;19(1):58. - Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.
Raverdeau M, Gely-Pernot A, Feret B, Dennefeld C, Benoit G, Davidson I, Chambon P, Mark M, Ghyselinck N
Proc Natl Acad Sci U S A, 2012;109(41):16582-7. - Anti-inflammatory effects of minocycline are mediated by retinoid signaling
V Clemens, F Regen, N Le Bret, I Heuser, J Hellmann-R
BMC Neurosci, 2018;19(1):58. - Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation
JP Ng-Blichfe, A Schrik, RK Kortekaas, JA Noordhoek, IH Heijink, PS Hiemstra, J Stolk, M Königshoff, R Gosens
EBioMedicine, 2018;36(0):461-474. - Higher-Order Kidney Organogenesis from Pluripotent Stem Cells
A Taguchi, R Nishinakam
Cell Stem Cell, 2017;0(0):. - Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells
F Pei, J Jiang, S Bai, H Cao, L Tian, Y Zhao, C Yang, H Dong, Y Ma
Stem Cell Res, 2017;19(0):94-103. - Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea.
Thiede B, Mann Z, Chang W, Ku Y, Son Y, Lovett M, Kelley M, Corwin J
Nat Commun, 2014;5(0):3840. - Systemic bud induction and retinioic acid signaling underlie whole body regeneration in the urochordate Botrylloides leachi.
Rinkevich et al.
PLoS Biology., 2007;5:e71 - Differential action on coregulator interaction defines retinoid agonists and neutral antagonists.
Germain et al.
Chem.Biol., 2009;16:479 - Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection.
Christoph Wilhelm, Oliver J Harrison, Vanessa Schmitt, Martin Pelletier, Sean P Spencer, Joseph F Urban, Michelle Ploch, Thirumalai R Ramalinga, Richard M Siegel, Yasmine Belkaid
The Journal of Experimental Medicine, 2016;0(0):1540-9538.
Citations for BMS 493(部分:文献)
The citations listed below are publications that use Tocris products. Selected citations for BMS 493 include:
29 Citations: Showing 1 - 10
- Retinoic acid inhibitors mitigate vision loss in a mouse model of retinal degeneration.
Authors: Richard H Et al.
Sci Adv 2022;8:eabm4643 - Tenogenic Induction From Induced Pluripotent Stem Cells Unveils the Trajectory Towards Tenocyte Differentiation.
Authors: Yasuyuki Et al.
Front Cell Dev Biol 2022;10:780038 - Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency.
Authors: Jennifer Et al.
Cell Stem Cell 2021;28:453-471.e8 - Retinoic acid signaling is directly activated in cardiomyocytes and protects mouse hearts from apoptosis after myocardial infarction.
Authors: Norbert B Et al.
Elife 2021;10 - Retinoic acid signalling in fibro/adipogenic progenitors robustly enhances muscle regeneration.
Authors: Min Et al.
EBioMedicine 2020;60:103020 - Retinoic Acid Signal Negatively Regulates Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells.
Authors: Jinsong Et al.
Stem Cells Int 2020;2020:5891783 - Local retinoic acid signaling directs emergence of the extraocular muscle functional unit.
Authors: Comai Et al.
PLoS Biol. 2020;18:e3000902 - Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression.
Authors: M Celeste Et al.
Cell 2020;180:1098-1114.e16 - A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages.
Authors: Wendy Et al.
Immunity 2019;51:119-130.e5 - A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult.
Authors: Tim Et al.
Immunity 2019;50:1276-1288.e5
Authors: Kelly A Et al.
Cell Host Microbe 2019;25:777-788.e8
Delayed onset of smooth muscle cell differentiation leads to hydroureter formation in mice with conditional loss of the zinc finger transcription factor gene Gata2 in the ureteric mesenchyme.
Authors: Rannar Et al.
J Pathol 2019;248:452-463
Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression.
Authors: Cordeiro Et al.
Structure 2019;
Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation.
Authors: Ng-Blichfeldt Et al.
EBioMedicine 2018;36:461
RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation.
Authors: Metzler Et al.
Development 2018;145
Retinoic acid signaling maintains epithelial and mesenchymal progenitors in the developing mouse ureter.
Authors: Bohnenpoll
Sci Rep 2017;7(1):14803
A Gene Regulatory Network Balances Neural and Mesoderm Specification during Vertebrate Trunk Development.
Authors: James Et al.
Dev Cell 2017;41:243-261.e7
Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+adipose progenitors.
Authors: Wang Et al.
Cell Discov 2017;3:17036
Retinoic acid signaling regulates Krt5 and Krt14 independently of stem cell markers in submandibular salivary gland epithelium.
Authors: Abashev Et al.
Dev Dyn 2017;246:135
Higher-Order Kidney Organogenesis from Pluripotent Stem Cells.
Authors: Ryuichi Et al.
Cell Stem Cell 2017;21:730-746.e6
Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells.
Authors: Pei Et al.
Stem Cell Res 2017;19:94
Maternal Retinoids Increase PDGFRα+ Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development.
Authors: Wang Et al.
EBioMedicine 2017;18:288
Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell- Mediated Immunity in Colorectal Cancer
Authors: Bhattacharya Et al.
Immunity 2016;45:1
Retinoic acid regulates embryonic development of mammalian submandibular salivary glands.
Authors: Lisa L Et al.
Dev Biol 2015;407:57-67
Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea.
Authors: Thiede Et al.
Nat Commun 2014;5:3840
Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity.
Authors: Pavert Et al.
Nature 2014;508:123
Retinoic acid receptor alpha is associated with tamox. resistance in breast cancer.
Authors: Johansson Et al.
Nat Commun 2013;4:2175
Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus.
Authors: Rankin Et al.
J Biol Chem 2012;139:3010
Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.
Authors: Raverdeau Et al.
Proc Natl Acad Sci U S A 2012;109:16582









