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- 详细信息
- 文献和实验
- 技术资料
- 库存：
30⁺瓶
- 英文名：
Calcipotriol
- CAS号：
112965-21-6
- 保质期：
1年
- 供应商：
上海睿安生物19121878899
- 保存条件：
-20°C
- 规格：
10mg/瓶
Tocris货号2700-10mg现货Calcipotriol上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899
Tocris货号2700-50mg现货Calcipotriol上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899
Chemical Name:(1α,3β,5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol
Purity:≥98%
Biological Activity
Calcipotriol is a vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60/MX2, keratinocytes, MCF-7, T47D, SCC-25, and mouse WEHI-3 cancer cell lines. Calcipotriol suppresses skin cancer development in mice in a thymic stromal lymphopoietin (TSLP)-dependent manner. Calcipotriol promotes the differentiation of keratinocytes. In human T cells and in psoriatic skin, Calcipotriol increases IL-10 secretion, induces secretion of type 2 cytokines by T cells and modulates the differentiation of dendritic cells and T cells.Technical Data
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only,unless stated otherwise.
Background References
- Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo.
Binderu
Pharmacol.Toxicol., 1993;72:240 - Pharmacokinetics and systemic effect on calcium homeostasis of 1α,24-dihydroxyvitamin D2 in rats.
Knutson et al.
Biochem.Pharmacol., 1997;53:829 - Antitumor properties of diastereomeric and geometric analogs of vitamin D3.
Wietrzyk et al.
Anticancer Drugs, 2007;18:447 - Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch
SK Mishra, JJ Wheeler, S Pitake, H Ding, C Jiang, T Fukuyama, JS Paps, P Ralph, J Coyne, M Parkington, J DeBrecht, LC Ehrhardt-H, GP Cruse, W Bäumer, RR Ji, MC Ko, T Olivry
Cell Rep, 2020;31(1):107472.
Citations for Calcipotriol(部分:文献)
The citations listed below are publications that use Tocris products. Selected citations for Calcipotriol include:
3 Citations:Showing 1 - 3
- RORα-expressing T regulatory cells restrain allergic skin inflammation.
Authors: Malhotra Et al.
Sci Immunol 2018;3 - Vitamin D switches BAF complexes to protect β cells.
Authors: Wei Et al.
Cell 2018;173:1135 - TSLP is differentially regulated by vitamin D3 and cytokines in human skin.
Authors: Landheer Et al.
Dev.Biol. 2015;3:32
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文献和实验Tocris货号2700-10mg现货Calcipotriol上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899
Tocris货号2700-50mg现货Calcipotriol上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899
Chemical Name:(1α,3β,5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol
Purity:≥98%
Biological Activity
Calcipotriol is a vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60/MX2, keratinocytes, MCF-7, T47D, SCC-25, and mouse WEHI-3 cancer cell lines. Calcipotriol suppresses skin cancer development in mice in a thymic stromal lymphopoietin (TSLP)-dependent manner. Calcipotriol promotes the differentiation of keratinocytes. In human T cells and in psoriatic skin, Calcipotriol increases IL-10 secretion, induces secretion of type 2 cytokines by T cells and modulates the differentiation of dendritic cells and T cells.Technical Data
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only,unless stated otherwise.
Background References
- Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo.
Binderu
Pharmacol.Toxicol., 1993;72:240 - Pharmacokinetics and systemic effect on calcium homeostasis of 1α,24-dihydroxyvitamin D2 in rats.
Knutson et al.
Biochem.Pharmacol., 1997;53:829 - Antitumor properties of diastereomeric and geometric analogs of vitamin D3.
Wietrzyk et al.
Anticancer Drugs, 2007;18:447 - Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch
SK Mishra, JJ Wheeler, S Pitake, H Ding, C Jiang, T Fukuyama, JS Paps, P Ralph, J Coyne, M Parkington, J DeBrecht, LC Ehrhardt-H, GP Cruse, W Bäumer, RR Ji, MC Ko, T Olivry
Cell Rep, 2020;31(1):107472.
Citations for Calcipotriol(部分:文献)
The citations listed below are publications that use Tocris products. Selected citations for Calcipotriol include:
3 Citations:Showing 1 - 3
- RORα-expressing T regulatory cells restrain allergic skin inflammation.
Authors: Malhotra Et al.
Sci Immunol 2018;3 - Vitamin D switches BAF complexes to protect β cells.
Authors: Wei Et al.
Cell 2018;173:1135 - TSLP is differentially regulated by vitamin D3 and cytokines in human skin.
Authors: Landheer Et al.
Dev.Biol. 2015;3:32
Characterization of Histaminergic Receptors
4 Agonists Histamine 6500 33,000 7.0 8.1 d Sigma Imetit 30,000 39,000 0.40 2.7 d RBI Immepip 22,000 >100,000 2.8 9.0 d Tocris Cookson
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