- ¥1380 - 2200
- LMAI Bio
- LM-0991R
- 进口/国产
- 2025年07月14日
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, HPV18
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-0991R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
HPV18 E6 protein
- 抗体名：
人类乳头状瘤病毒18 E6抗体
- 宿主：
Rabbit
- 适应物种：
Human, HPV18
- 免疫原：
Synthetic peptide from the HPV18 E6 protein conjugated to KLH:75-158/158
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | HPV18 E6 protein |
| 中文名称 | 人类乳头状瘤病毒18 E6抗体 |
| 别 名 | E6; Human Papilloma Virus; Human papillomavirus type 18 E6; Human papillomavirus type 18 (E6); Human papillomavirus type 18 E6; Human papillomavirus type 18 E6 protein; Protein E6; HPV18 E6 protein; VE6_HPV18. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 肿瘤 细菌及病毒 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, HPV18 |
| 产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 11kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | Synthetic peptide from the HPV18 E6 protein conjugated to KLH:75-158/158 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro. Function: Transcriptional transactivator. Binds double stranded DNA (By similarity). Has transforming activity. Inactivates, with E6-AP ubiquitin-protein ligase, the human p53/TP53 tumor suppressor protein by targeting it to degradation. Binds and targets human MUPP1/MPDZ protein to degradation. Those two functions presumably contribute to transforming activity. Interaction with human FBLN1 protein also seems to be linked to cell transformation. Subunit: Forms a complex with E6-AP ubiquitin-protein ligase which interacts with human P53. Binds to human FBLN1, MAGI3 and MPDZ. Subcellular Location: Host nucleus matrix (By similarity). Similarity: Belongs to the papillomaviridae E6 protein family. SWISS: P06463 Gene ID: 1489088 Database links: Entrez Gene: 1489088 HPV18 E6 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 人类乳头状瘤病毒18（HPV18-E6）是导致女性宫颈癌的主要病毒型（包括人类乳头状瘤病毒16） |
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文献和实验红的是E6的开放读码，兰色的是E7的开放读码，中间有几个碱基，在基因组中E6和E7就是这样排列的， 请教各位高手，我如果简单的把上述E6E7的完整片段插到真核表达系统，能否做到E6E7的共同表达？如何分析，请指教 关于双基因的表达问题：我查了一些资料，里面很有学问。
In Vitro Assays of Substrate Degradation Induced by High-Risk HPV E6 Oncoproteins
was the p53 tumor suppressor protein, and since then many other substrates for E6-induced degradation have been described. All of these require the presence of high-risk mucosal E6 together with the E1, E2, and E3 enzymes of the ubiquitin pathway
Immortalization of Human Prostate Cells With the Human Papillomavirus Type 16 E6 Gene
A survey of the Medline titles for the years 2000–2001 revealed 125 papers whose titles included the name of the androgen-sensitive prostate cancer cell line LNCaP, and 36 papers also included PC3, the most common androgen independent line
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