CD14内毒素受体抗体

CD14内毒素受体抗体

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  • ¥780 - 2200
  • LMAI Bio
  • LM-1192R
  • 进口/国产
  • 2025年07月11日
  • WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
  • Rabbit
  • Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, 
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    • 详细信息
    • 技术资料
    • 供应商

      上海联迈生物工程有限公司

    • 库存

      大量

    • 目录编号

      LM-1192R

    • 克隆性

      多克隆

    • 抗原来源

      Rabbit

    • 保质期

      1年

    • 抗体英文名

      CD14

    • 抗体名

      内毒素受体抗体

    • 宿主

      Rabbit

    • 适应物种

      Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, 

    • 免疫原

      KLH conjugated synthetic peptide derived from mouse CD14:201-300/366 

    • 亚型

      IgG

    • 形态

      Lyophilized or Liquid

    • 应用范围

      WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)

    • 浓度

      1mg/ml

    • 保存条件

      Store at -20 °C

    • 规格

      50ul  100ul  200ul

    CD14内毒素受体抗体
    英文名称 CD14
    中文名称 内毒素受体抗体
    别    名 CD14 antigen; CD14 molecule; Lipopolysaccharide receptor; LPSR; Monocyte Differentiation Antigen 14; Monocyte differentiation antigen CD14; Myeloid cell specific leucine rich glycoprotein; CD14_MOUSE; Myeloid cell-specific leucine-rich glycoprotein.  
    CD14内毒素受体抗体 Specific References  (6)     |     bs-1192R has been referenced in 6 publications.
    [IF=3.48] Chen, Xiaoming, et al. " Sargassum fusiforme polysaccharide activates nuclear factor kappa-B (NF-κB) and induces cytokine production via Toll-like receptors." Carbohydrate Polymers (2014).  other ;  Rat.  
    PubMed:24708959
    [IF=7.81] Chen, Yen‐Ta, et al. "Melatonin Treatment further Improves Adipose‐Derived Mesenchymal Stem Cell Therapy for Acute Interstitial Cystitis in Rat." Journal of Pineal Research (2014).  IHC-P ;  Rat.  
    PubMed:25132326
    [IF=2.14] Nau, Christoph, et al. "Alteration of Masquelets induced membrane characteristics by different kinds of antibiotic enriched bone cement in a critical size defect model in the rats femur." Injury (2015).  IHC-P ;  Rat.  
    PubMed:26652225
    [IF=1.58] Sun, Bing, et al. "Tight junction proteins and gap junction proteins play important roles in high fat dietary atherosclerosis pathogenesis." Int J Clin Exp Pathol 9.8 (2016): 7969-7976.  IHC-P ;  Rat.  
    PubMed:0
    [IF=0.52] "Utomo, Pamudji, et al. ""Decreasing SDF1-CXCR4 Expression after Adipose-Derived Mesenchymal Stem Cells (ASCS) Treatment Combined with Freeze-Dried Amniotic Membrane Wrapping in Rat Sciatic Nerve Injury."" International Journal of ChemTech Research. "  IF(ICC) ;  Rat.  
    PubMed:0
    [IF=3.15] Sun, Cheuk-Kwan, et al. "Melatonin treatment enhances therapeutic effects of exosomes against acute liver ischemia-reperfusion injury." Am J Transl Res 9.4 (2017): 1543-1560.  IHC-P ;  Rat.  
    PubMed:28469765
    规格价格 50ul/780元 购买    100ul/1380元 购买    200ul/2200元 购买    大包装/询价
    说 明 书 50ul  100ul  200ul
    研究领域 细胞生物  免疫学  干细胞  细胞表面分子  细胞类型标志物  淋巴细胞  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, 
    产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 35/40kDa
    细胞定位 细胞膜 
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from mouse CD14:201-300/366 
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    PubMed PubMed
    产品介绍 background:
    The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]

    Function:
    Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.

    Subunit:
    Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4.

    Subcellular Location:
    Cell membrane; Lipid-anchor, GPI-anchor.

    Similarity:
    Contains 11 LRR (leucine-rich) repeats.

    SWISS:
    P10810

    Gene ID:
    12475

    Database links:

    Entrez Gene: 929 Human

    Entrez Gene: 12475 Mouse

    Omim: 158120 Human

    SwissProt: P08571 Human

    Unigene: 163867 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

    CD14又称内毒素受体,属细胞表面糖蛋白家族成员之一。在机体免疫、防御系统引起的一系列反应中介导细胞识别LPS并引起细胞酪氨酸磷酸化、核因子NF-κB转位、触发细胞因子释放和氧自由基产生。CD14在细胞因子产生的调控方面起重要作用,因而对于CD14结构、功能及其临床意义的研究日益受到重视。
    产品图片 CD14内毒素受体抗体
    Protein: mouse lung lysate; 
    Primary: rabbit Anti-CD14(bs-1192R) at 1:300; 
    Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000; 
    Predicted band size: 40 kD
    Observed band size: 40 kD
    CD14内毒素受体抗体
    Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; 
    Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; 
    Incubation: Anti-CD14 Polyclonal Antibody, Unconjugated(bs-1192R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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