Immortalization of Human Prostate Cells With the Human Papillomavirus Type 16 E6 Gene

A survey of the Medline titles for the years 2000–2001 revealed 125 papers whose titles included the name of the androgen-sensitive prostate cancer cell line LNCaP, and 36 papers also included PC3, the most common androgen independent line. With the addition of DU145 the list of human experimental prostate cell systems is almost exhausted, although recently new sets of cell lines, immortalized by viral and nonviral genes, have begun to appear to augment the list (1 –5 ).