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- Sino Biological
- 10433-H03H
- 2025年08月12日
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100 µg
蛋白名称：VE-Cadherin蛋白, VE-Cadherin protein
蛋白构建：A DNA sequence encoding the extracellular domain of human CDH5 (NP_001786.2) (Met 1-Gln 593) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
表达宿主：HEK293 Cells
蛋白纯度：> 85 % as determined by SDS-PAGE
蛋白活性：0
蛋白内毒素：< 1.0 EU per μg of the protein as determined by the LAL method
预测N端：Ala 26
蛋白分子量：The recombinant human CDH5/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 815 amino acids after removal of the signal peptide and has a predicted molecular mass of 92 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh CDH5/Fc monomer is approximately 120 kDa due to glycosylation.
蛋白NP号：NP_001786.2
蛋白氨基酸序列：Met1-Gln593
蛋白标签：C-human IgG1-Fc & His
蛋白保存条件：Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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文献和实验钙粘着蛋白(cadherin)是细胞质膜中的细胞粘着分子,但是这种分子介导的细胞粘着受Ca2 的调节。钙粘着分子家族中比较熟知的属于膜整合糖蛋白的成员有:E-钙粘着蛋白(主要在表皮组织中)、N-钙粘着蛋白(存在神经组织中)、P-钙粘着蛋白(主要存在于胎盘)。钙粘着蛋白的细胞外部分有600个氨基酸残基,组成四个重复的Ca2 结合结构域,细胞质部分有150个氨基酸。
human E-cadherin-IgG Fc domain fusion protein (E-cad-Fc) has recently been shown to be extremely efficient in facilitating the culture of human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells under completely defined conditions
Cadherin-Mediated Cell-Cell Interactions
-4) Human, mouse, chicken, Xenopus Eye (retina, pigmented epithelium), brain, skeletal muscle, pancreas, gastrointestinal tract VE-Cadherin (cadherin-5
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