
全局信号转导网络Global Signal Transduc
tion Network- 询价
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- 2025年07月09日
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全局信号转导网络—Global Signal Transduction Network
利用数据库中KEGG、BIND、HPRD等信号传递通路,以及基因、蛋白质、化合物之间的作用关系,构建目标基因群中,基因与基因产物间的信号传递网络,通过信号转导网络得到基因间的相互作用关系,信号转导网络通过图论分析方法可以得到网络的核心调节基因,反映样本在全局层面的基因调节机制。
文章案例1:研究构建H2AX低表达A549细胞,与对照A549细胞进行表达谱检测,经差异分析和功能通路富集分析后,构建全局信号转导网络,根据属性值degree筛选排名前十的基因,进一步采用PCR验证。(芯片检测+数据分析由中康博提供)
参考文献:Chengrong Lu et al. Genome-wide transcriptional analysis of apoptosis-related genes and pathways regulated by H2AX in lung cancer A549 cells. Apoptosis. 2013 .
文章案例2:实验分为对照组 和SiNPs处理组,斑马鱼为研究对象,对两分组3:3样本进行表达谱检测, 经差异和功能通路富集后,进一步构建全局信号转导网络,筛选出核心的差异基因,并根据degree值及自身研究选择个基因(如jak1、jak2a)进一步验证。(芯片检测+数据分析由中康博提供)
参考文献:Genome-wide transcriptional analysis of cardiovascular-related genes and pathways induced by PM2.5 in human myocardial cells. 2017. Environ Sci Pollut Res.
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文献和实验The Phosphoinositide Signal Transduction System
components can contribute to the phosphoinositide second-messenger system to transduce signals. However, most commonly the phosphoinositide signal transduction system is considered to consist of receptors with seven membrane-spanning domains containing
The Role of Redox in Signal Transduction
be dictated by the presence of pro-oxidants and antioxidants. Here, the chemistry of redox modification of amino acids is introduced, and a general overview of the role of redox in mediating signal transduction is given.
Computer Simulation of MAPK Signal Transduction
We predict that computational modeling platforms will soon become standard tools in experimental laboratories involved in the study of complex regulatory networks of various cellular processes—a field of research where an avalanche of genomic
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