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- bs-4278R
- 2025年10月24日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-4278R |
| 英文名称 | FAT Rabbit pAb |
| 中文名称 | 钙粘蛋白家族成员7抗体 |
| 英文别名 | Cadherin family member 7; cadherin family member 7 precursor; cadherin ME5; Cadherin related tumor suppressor; Cadherin related tumor suppressor homolog; cadherin related tumor suppressor homolog precursor; Cadherin related tumor suppressor homolog precursor(FAT protein homolog); CDHF 7; CDHF7; FAT 1; FAT tumor suppressor 1; FAT tumor suppressor homolog 1; FAT1; hFat 1; hFAT; hFat1; homolog of Drosophila FAT protein; homolog of Drosophila FAT protein precursor; homolog of Drosophila tumor suppressor FAT precursor; ME 5; ME5; Protein fat homolog. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Rat (Human, Mouse, Dog, Pig, Cow, Horse) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human FAT/CDHF7 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 506 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cell cycle > Cell cycle inhibitors Cancer > Invasion/microenvironment > ECM > Cell adhesion > Cadherins Cell Biology > Cell Cycle > Cell Cycle Inhibitors Epigenetics and Nuclear Signaling > Transcription > Cancer susceptibility > Tumor Suppressors Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Cadherins |
| 亚基 | Interacts (via the C-terminus 4300-4400 AA) with ATN1. Interacts with RERE. Interacts (via EVH1 domains) with ENAH. Interacts (via cytoplasmic domain) with CTNNB1. |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. Nucleus Cytoplasm, perinuclear region. |
| 组织特异性 | Expressed in many epithelial and some endothelial and smooth muscle cells. |
| 翻译后修饰 | Undergoes proteolytic cleavage. The extracellular domain is cleaved off and the cytoplasmic domain (about 400 AA) shuttles to the nucleus. |
| 功能 | Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq]. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
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文献和实验= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
).You will need a medium size (longish but not too fat)stir bar that will still spin when the module is inserted (IMPORTANT)and also place the frozen buffer dam in next to the module.Add enough buffer to fill but not overflow.2.Transfer at 41 volts (about 160-180 mA
results. Incubate. 3. Dump out the antigen solution and add 100 µL of blocking buffer (1% BSA, 0.1 M KPi, 0.1% Tween-20, 0.02% thimerisol, pH 7). If your carrier protein for injection was BSA, then substitute 1% non-fat dry milk for the BSA. Incubate
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