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- 2025年10月16日
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产品信息以Bioss网站为准
- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-7531R |
| 英文名称 | Insulin Receptor R Rabbit pAb |
| 中文名称 | 胰岛素受体相关受体抗体 |
| 英文别名 | INSRR; Insulin receptor related receptor precursor; IR related receptor; IRR; Sirr; Insulin receptor-related protein; IR-related receptor; Insulin receptor-related protein beta chain; INSRR_HUMAN. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Dog, Pig, Cow, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Insulin receptor-related protein beta chain |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 129 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Atherosclerosis > Diabetes associated Metabolism > Types of disease > Cancer Metabolism > Types of disease > Diabetes Metabolism > Types of disease > Heart disease Neuroscience > Neurology process > Metabolism Signal Transduction > Growth Factors/Hormones > Insulin / Insulin-like Signal Transduction > Protein Phosphorylation > Tyrosine Kinases > Receptor Tyrosine Kinases |
| 亚基 | Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 翻译后修饰 | Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5. |
| 相似性 | Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 3 fibronectin type-III domains. Contains 1 protein kinase domain. Contains 1 protein kinase domain. |
| 功能 | Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The insulin receptor related receptor (IRR) is a heterotetrameric transmembrane receptor composed of two alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Member of the insulin RTK family, IRR shares high homology with the insulin (IR) and the insulin-like growth factor-1 receptor (IGF-1R), but doesn’t bind any of IR and IGF-1R known ligands. In contrast to the widespread patterns of expression to IR and IGF-1R, IRR demonstrates a very restricted cellular distribution in a subset of tissues of neuronal origin and its biological functions are still unknown. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
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文献和实验Characterization of CGRP Receptor Binding
Chatterjee, T.K. and Fisher, R.A. 1991. Multiple affinity forms of the calcitonin gene‐related peptide receptor in rat cerebellum. Mol. Pharmacol. 39:798‐804. Choksi, T
Assessment of Insulin-Like Growth Factors and Mutagen Sensitivity as Predictors of Lung Cancer Risk
-2), two types of cell membrane receptors (IGF-1R and IGF-2R), and six binding proteins (IGFBP1-6) (1 ,2 ). This family of growth factors has several important functions. IGF-mediated activation of the IGF-1 receptor stimulates the signal transduction pathway
Overview of Receptor Allosterism
. Bruns, R.F. and Fergus, J.H. 1990. Allosteric enhancement of adenosine A1 receptor binding and function by 2‐amino‐3‐benzoylthiophenes. Mol. Pharmacol. 38:939‐949.
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