ADAR | ADAR1 Rabbit pAb(bs-2168R)-50ul/100ul/200ul产品图
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ADAR | ADAR1 Rabbit pAb(bs-216

8R)-50ul/100ul/200ul
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  • ￥1180 - 2800
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  • bs-2168R
  • 2026年10月13日
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    北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-2168R
    英文名称ADAR1 Rabbit pAb
    中文名称双链RNA腺苷酸脱氨基酶（C端）抗体
    英文别名136kDa double stranded RNA binding protein; Adar 1; ADAR; Adar1; Adenosine deaminase RNA specific 1; Adenosine deaminase RNA specific; Adenosine deaminase that act on RNA; AV242451; Double stranded RNA specific adenosine deaminase; Double-stranded RNA-specific editase Adar; Drada; Dsh; Dsrad; dsRNA adenosine deaminase; EC 3.5.4.-; G1P1; IFI 4; IFI4; Ifi4 protein; Interferon induced protein 4; Interferon inducible protein 4; K88dsrbp; mZaADAR; p136; Pre-mRNA adenosine deaminase; RNA adenosine deaminase 1; RNA-editing deaminase 1; RNA-editing enzyme 1.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse, Rat
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human DRADA
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量135 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    亚基Homodimer. Isoform 1 interacts with ILF2/NF45 and ILF3/NF90.
    亚细胞定位Cytoplasm. Nucleus, nucleolus. Isoform 1: Cytoplasm. Note=Found predominantly in cytoplasm but appears to shuttle between the cytoplasm and nucleus. Isoform 5: Nucleus, nucleolus.
    组织特异性Ubiquitously expressed, highest levels were found in brain and lung.
    翻译后修饰Sumoylation reduces RNA-editing activity.
    相似性Contains 1 A to I editase domain._x000D_
    Contains 2 DRADA repeats._x000D_
    Contains 3 DRBM (double-stranded RNA-binding) domains.
    功能Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site-selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料ADAR1 converts adenosine to inosine in dsRNA, which destabilizes the dsRNA helix. This activity is important for various functions like site-specific RNA editing of transcripts of the glutamate receptors and modifying viral RNA genomes (which may be responsible for hypermutation of certain negative-stranded viruses, e.g., measles virus). ADAR1 also binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. This protein is ubiquitously expressed, with the highest levels being found in brain and lung.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    P‌‌araformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ADAR1) Polyclonal Antibody, Unconjugated (bs-2168R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody (sp-0023) for 20 minutes and DAB staining.
    产品细节图片2
    Sample:
    _x000D_ A549(Human) Cell Lysate at 30 ug
    _x000D_ Primary: Anti-ADAR1 (bs-2168R) at 1/1000 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 135 kD
    _x000D_ Observed band size: 110 kD
    产品细节图片3
    Sample:
    _x000D_ NIH/3T3(Mouse) Cell Lysate at 30 ug
    _x000D_ Cerebrum (Mouse) Lysate at 40 ug
    _x000D_ Primary: Anti-ADAR1 (bs-2168R) at 1/1000 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 135 kD
    _x000D_ Observed band size: 110 kD
    产品细节图片4
    Sample:
    _x000D_ HepG2(Human) Cell Lysate at 30 ug
    _x000D_ Primary: Anti-ADAR1 (bs-2168R) at 1/1000 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 135 kD
    _x000D_ Observed band size: 110 kD

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    图标文献和实验
    该产品被引用文献
    [1]A novel mechanism for A-to-I RNA-edited CYP1A1 in promoting cancer progression in NSCLC.
    PMID:40175891Cell Mol Biol Lett2025-04
    [2]Integrated analysis of RNA methylation regulators crosstalk and immune infiltration for predictive and personalized therapy of diabetic nephropathy.
    PMID:36765416Hum Genomics2023-02-10
    [3]circHtra1/miR-3960/GRB10 Axis Promotes Neuronal Loss and Immune Deficiency in Traumatic Brain Injury.
    PMID:35571247Oxid Med Cell Longev2022-05-06
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    ADAR | ADAR1 Rabbit pAb(bs-2168R)-50ul/100ul/200ul
    ￥1180 - 2800