CD163 Rabbit pAb(bs-2527R)-50ul/100ul/200ul
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CD163 Rabbit pAb(bs-2527R)-50u

l/100ul/200ul
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  • ￥1180 - 2800
  • Bioss已认证
  • bs-2527R
  • 2025年10月16日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-2527R
    英文名称CD163 Rabbit pAb
    中文名称CD163抗体
    英文别名Scavenger receptor cysteine-rich type 1 protein M130; CD 163; CD163 antigen; CD163 molecule; Hemoglobin Scavenger Receptor; M130; M130 antigen precursor; Macrophage associated antigen; MM130; C163A_HUMAN.
    产品应用IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Rat, Mouse
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human CD163
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量130 kDa
    实际分子量134(non-reduced)/155kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cardiovascular > Atherosclerosis > Vascular Inflammation > Innate and adaptive immunity

    Immunology > Cell Type Markers > CD > Myeloid Cells

    Immunology > Innate Immunity > Macrophage / Inflamm.

    亚细胞定位Secreted and Cell membrane. Isoform 1 and isoform 2 show a lower surface expression when expressed in cells.
    组织特异性Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.
    翻译后修饰A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs. Phosphorylated.
    相似性Contains 9 SRCR domains.
    功能Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}
    {WB}{1:500-2000}

     

    CD163 Rabbit pAb(bs-2527R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Rat Lung; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with CD163 Polyclonal Antibody, Unconjugated (bs-2527R) at 1:100 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    CD163 Rabbit pAb(bs-2527R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Human Lung; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with CD163 Polyclonal Antibody, Unconjugated (bs-2527R) at 1:100 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    CD163 Rabbit pAb(bs-2527R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Mouse Lung; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with CD163 Polyclonal Antibody, Unconjugated (bs-2527R) at 1:100 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    CD163 Rabbit pAb(bs-2527R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Rat Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with CD163 Polyclonal Antibody, Unconjugated (bs-2527R) at 1:100 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    CD163 Rabbit pAb(bs-2527R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Human Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with CD163 Polyclonal Antibody, Unconjugated (bs-2527R) at 1:100 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    CD163 Rabbit pAb(bs-2527R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Mouse Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with CD163 Polyclonal Antibody, Unconjugated (bs-2527R) at 1:100 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    CD163 Rabbit pAb(bs-2527R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Rat Spleen; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with CD163 Polyclonal Antibody, Unconjugated (bs-2527R) at 1:100 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    CD163 Rabbit pAb(bs-2527R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Human Spleen; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with CD163 Polyclonal Antibody, Unconjugated (bs-2527R) at 1:100 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    CD163 Rabbit pAb(bs-2527R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Rat Placenta; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with CD163 Polyclonal Antibody, Unconjugated (bs-2527R) at 1:100 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    CD163 Rabbit pAb(bs-2527R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Human Placenta; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with CD163 Polyclonal Antibody, Unconjugated (bs-2527R) at 1:100 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    CD163 Rabbit pAb(bs-2527R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Human Lung Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with CD163 Polyclonal Antibody, Unconjugated (bs-2527R) at 1:100 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    CD163 Rabbit pAb(bs-2527R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Human Colon Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with CD163 Polyclonal Antibody, Unconjugated (bs-2527R) at 1:100 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    CD163 Rabbit pAb(bs-2527R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Human Ovarian mucinous carcinoma; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with CD163 Polyclonal Antibody, Unconjugated (bs-2527R) at 1:100 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    CD163 Rabbit pAb(bs-2527R)-50u
    25 ug total protein per lane of various lysates (see on figure) probed with CD163 polyclonal antibody, unconjugated (bs-2527R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
    CD163 Rabbit pAb(bs-2527R)-50u
    25 ug total protein per lane of various lysates (see on figure) probed with CD163 polyclonal antibody, unconjugated (bs-2527R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
    CD163 Rabbit pAb(bs-2527R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Human Colon; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with CD163 Polyclonal Antibody, Unconjugated (bs-2527R) at 1:200 overnight at 4°C. Followed by conjugated Goat Anti-Rabbit IgG antibody (green, bs-0295G-BF488), DAPI (blue, C02-04002) was used to stain the cell nuclei.
    CD163 Rabbit pAb(bs-2527R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Human Placenta; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with CD163 Polyclonal Antibody, Unconjugated (bs-2527R) at 1:200 overnight at 4°C. Followed by conjugated Goat Anti-Rabbit IgG antibody (green, bs-0295G-BF488), DAPI (blue, C02-04002) was used to stain the cell nuclei.

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    图标文献和实验
    该产品被引用文献

    [IF={{ 9.4 }}] {Aldona Mzyk. et al. Quantum sensing to monitor changes in free radical generation by intracellular vesicles of polarized macrophages. ACTA BIOMATER. 2025 Apr;:} {FC} {Mouse}

    [IF={{ 9.071 }}] {Giorgio Caratti. et al. Macrophagic AMPKα1 orchestrates regenerative inflammation induced by glucocorticoids. EMBO REP. 2022 Dec 15} {IF} {Mouse}

    [IF={{ 8.947 }}] {Junpeng Chen. et al. An all-in-one CO gas therapy-based hydrogel dressing with sustained insulin release, anti-oxidative stress, antibacterial, and anti-inflammatory capabilities for infected diabetic wounds. ACTA BIOMATER. 2022 Apr;:} {WB,IF} {Mouse}

    [IF={{ 8.897 }}] {Liu, Houli. et al. Immunomodulatory hybrid bio-nanovesicle for self-promoted photodynamic therapy. Nano Res. 2022 Feb;:1-10} {WB} {Mouse}

    [IF={{ 8.579 }}] {Tong L et al. ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma. Theranostics. 2020 May 1;10(13):5943-5956.} {IHC} {Mouse}

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    文献支持
    CD163 Rabbit pAb(bs-2527R)-50ul/100ul/200ul
    ￥1180 - 2800