Esomeprazole potassium salt是一种

Esomeprazole potassium salt  (Synonyms: 艾美拉唑钾盐; (S)-Omeprazole potassium salt; (-)-Omeprazole potassium salt)

Esomeprazole potassium salt ((S)-Omeprazole potassium salt) 是一种有效的具有口服活性质子泵抑制剂，可通过抑制胃壁细胞中的 H⁺, K⁺-ATPase 来降低酸分泌，并可用于胃食管反流疾病的研究。

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生物活性    
Esomeprazole potassium salt ((S)-Omeprazole potassium salt) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole potassium salt has the potential for symptomatic gastroesophageal reflux disease research[1][2][3].

IC50 & Target    
H+, K+-ATPase[1][2]

体外研究
(In Vitro)    
Esomeprazole (25-100 µM; 20 hours; MDA-MB-468 cells) treatment suppresses growth of triple-negative breast cancer cell in vitro in a dose-dependent manner through increase in their intracellular acidification[1].


Cell Viability Assay[1]

Cell Line:    MDA-MB-468 cells
Concentration:    25 µM, 50 µM, 75 µM, 100 µM
Incubation Time:    20 hours
Result:    Suppressed growth of triple-negative breast cancer cell in vitro in a dose-dependent manner.

体内研究
(In Vivo)    
Esomeprazole (30-300 mg/kg; oral gavage; daily; for 19 or 11 days; C57BL/6J mice) treatment significantly inhibits the progression of fibrosis throughout the lungs of the animals. Esomeprazole also reduces circulating markers of inflammation and fibrosis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:    C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury[2]
Dosage:    30 mg/kg, 300 mg/kg
Administration:    Oral gavage; daily; for 19 or 11 days
Result:    Significantly inhibited the progression of fibrosis throughout the lungs of the animals.

分子量    
383.51

Formula    
C17H18KN3O3S

CAS 号    
161796-84-5

中文名称    
埃索美拉唑钾盐

运输条件    
Room temperature in continental US; may vary elsewhere.

储存方式    
Please store the product under the recommended conditions in the Certificate of Analysis.