- ￥2570 - 3220
- Sino Biological
- 北京
- 10676-H07B
- 2025年08月12日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20℃ to -80℃
- 保质期：
12个月
- 英文名：
Recombinant Human PLK1 / PLK-1 Protein (His Tag)
- 库存：
99
- 供应商：
北京义翘神州科技股份有限公司
- 规格：
20.00 µg/50.00 µg
| 规格： | 20.00 µg | 产品价格： | ￥2570.0 |
|---|---|---|---|
| 规格： | 50.00 µg | 产品价格： | ￥3220.0 |
蛋白名称：Human PLK1 / PLK-1 Protein (His Tag)
蛋白构建：A DNA sequence encoding the human PLK1 (NP_005021.2) (Met 1-Ser 603) was expressed, with a polyhistidine tag at the N-terminus.
表达宿主：Baculovirus-Insect Cells
蛋白纯度：> 90 % as determined by SDS-PAGE
蛋白活性：The specific activity was determined to be ＞3 nmol/min/mg using casein as substrate.
蛋白内毒素：< 1.0 EU per μg of the protein as determined by the LAL method
预测N端：His
蛋白分子量：The recombinant human PLK1 consists of 621 amino acids and predicts a molecular mass of 70.5 kDa. It migrates as an approximately 66 kDa band in SDS-PAGE under reducing conditions.
蛋白NP号：NP_005021.2
蛋白氨基酸序列：Met1-Ser603
蛋白标签：N-His
蛋白保存条件：Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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文献和实验2, Chapagai D, et al. Structural Basis for Variations in Polo-like Kinase 1 Conformation and Intracellular Stability Induced by ATP-Competitive and Novel Noncompetitive Abbapolin Inhibitors.ACS chemical biology, PubMed ID: 37433100
3, Gao Z, et al. Polo-like kinase 1 promotes sepsis-induced myocardial dysfunction.International immunopharmacology, PubMed ID: 37879229
4, Zhang Y, et al. Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis.Cell reports, PubMed ID: 38968071
Polo-like kinase 1 (Plk1) is a key player in mitosis and has been widely recognized as a therapeutic target for many human cancer types. Apart from its kinase domain, Plk1 harbors a protein–protein interaction domain dubbed “polo-box domain
Chromatin Interaction Analysis Using Paired‐End Tag Sequencing
Analysis using Paired?End Tag sequencing (ChIA?PET) is a technique developed for large?scale, de novo analysis of higher?order chromatin structures. Cells are treated with formaldehyde to cross?link chromatin interactions, DNA segments bound by protein
.3 ). Concatamers of tags are cloned and sequenced to yield a STAGE library. Tags in the library represent DNA fragments that were occupied by the DNA?binding protein, and mapping these tag sequences to the genome identifies the binding loci of the DNA?binding
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