TBK1/NAK Antibody产品图

TBK1/NAK Antibody

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  • 询价
  • Cell Signaling Technology已认证
  • USA
  • 2026年05月28日
  • W, IP
  • Rabbit
  • H,M,R,Mk
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    • 详细信息
    • 询价记录
    • 文献和实验
    • 技术资料
    • 抗体英文名

      TBK1/NAK Antibody

    • 抗原

      synthetic peptide corresponding to residues near the carboxy-terminus of TBK1/NAK

    • 应用范围

      W, IP

    • 宿主

      Rabbit

    • 库存

      大量

    • 供应商

      CST

    • 适应物种

      H,M,R,Mk

    • 级别

      详见MSDS文件

    • 保质期

      详见说明书

    • 是否单克隆

      2

    • 保存条件

      -20°c

    • 规格

      100 ul (10 western blots)/carrier free & custom formulation / quantity

    规格:产品价格:¥请询价
    规格:100 ul (10 western blots)产品价格:¥请询价
    规格:carrier free & custom formulation / quantity产品价格:¥请询价

    pathway more info application references datasheet PDF MSDS PDF protocols

    Applications Key:  W=Western Blotting  IP=Immunoprecipitation
    Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Monkey
    Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

    Applications Reactivity Sensitivity MW (kDa) Source
    W IP H M R Mk Endogenous 84 Rabbit
    Protocols
    Specificity / Sensitivity

    TBK1 Antibody detects endogenous levels of total TBK1/NAK protein.

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy-terminus of TBK1/NAK. Antibodies were purified by protein A and peptide affinity chromatography.

    Western Blotting

    Western Blotting

    Western blot analysis of extracts from HeLa (human), BaF3 (mouse) and KNRK (rat) cell lines, using TBK1/NAK Antibody.

    Background

    TBK1 (TANK-binding kinase 1)/NAK (NF-κB activating kinase) is an IκB kinase (IKK)-activating kinase and can activate IKK through direct phosphorylation (1). TBK1 was identified through association with the TRAF binding protein, TANK, and found to function upstream of NIK and IKK in the activation of NF-κB (2). TBK1/NAK induces IκB degradation and NF-κB activity through IKKβ. NAK may mediate IKK and NF-κB activation in response to growth factors that stimulate PKCε activity (1). TBK1 plays a pivotal role in the activation of IRF3 in the innate immune response (3).

    1. Tojima, Y. et al. (2000) Nature 404, 778-82.
    2. Pomerantz, J.L. and Baltimore, D. (1999) EMBO J 18, 6694-704.
    3. Fitzgerald, K.A. et al. (2003) Nat Immunol 4, 491-6.
    Application References

    Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know !

    Companion Products

    For Research Use Only. Not For Use In Diagnostic Procedures.

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    图标文献和实验
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    相关实验
    • Generation of Antibody Molecules Through Antibody Engineering

      been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional

    • The Antibody Molecule

      The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera

    • Antibody Storage

        General comments: Antibodies, like most proteins, do not like to be freeze-thawed. Avoid repetitive freezing of your solution. The best way to store your antibody is to keep a high protein concentration (>1 mg/ml), add some protease

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