- 询价
- Cell Signaling Technology
- 3372
- USA
- 2025年08月14日
- W, IP
- Rabbit
- H,M,R,Mk
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
Erk5 Antibody
- 抗原：
synthetic peptide corresponding to human Erk5
- 应用范围：
W, IP
- 宿主：
Rabbit
- 保质期：
详见说明书
- 供应商：
CST
- 级别：
详见MSDS文件
- 库存：
大量
- 适应物种：
H,M,R,Mk
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP | H M R Mk | Endogenous | 115 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Erk5 Antibody detects endogenous levels of total Erk5 protein. This antibody does not cross-react with Erk1 or Erk2. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to human Erk5. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from HeLa cells, untreated or sorbitol-treated and NIH/3T3 cells, untreated or PDGF-treated, using Erk5 Antibody. |
| Background | ERK5 (Mitogen-activated protein kinase 7, Big mitogen-activated protein kinase 1) is a member of the MAPK superfamily implicated in the regulation numerous cellular processes including proliferation, differentiation and survival (1,5-7). Like other MAPK family members, ERK5 contains a canonical activation loop TEY motif (Thr218/Tyr220) which is specifically phosphorylated by MAP2K5 (MEK5) in a growth factor-dependent, Ras-independent mechanism (2-4). For example, EGF stimulation promotes ERK5 phosphorylation which induces its traslocation to the nucleus where it phosphorylates MEF2C and other transcriptional targets (2,3). ERK5 is also activated in response to granulocyte colony-stimulating factor (G-CSF) in hematopoetic progenitor cells where is promotes survival and proliferation (4). In neuronal cells, ERK5 is required for NGF-induced neurite outgrowth neuronal homeostatis and survival (11,12). ERK5 is thought to play a role in blood vessel integrity via maintainence of endothelial cell migration and barrier function (8-10). Although broadly expressed, mice lacking erk5 display numerous cardiac defects, suggesting ERK5 plays a critical role in vascular development and homeostasis (1,5).
|
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验Investigating the Cellular BMK1/ERK5 Signaling Pathway
Big mitogen-activated protein kinase 1 (BMK1), also known as extracellular signal-regulated kinase 5 (ERK5), is the most recently identified member of the mammalian mitogen-activated protein kinase (MAPK) family (1 ,2 ). Cellular activation
相关专题 MAPK信号通路专题 丝裂原活化蛋白激酶(MAPK)信号通路 是在体内的信号转导系统的一个重要。亚科包括ERK1 / 2，JNK，p38和电子档案保管系统。最近的研究发现，ERK5细胞增殖，分化和调节细胞功能中起着重要的作用，在参与一些疾病的发生和发展。 The Erk5 MAPK signaling pathway, also known as the big MAP kinase
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
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