- 询价
- R&D
- 美国/中国
- xy-563P
- 2025年07月12日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 文献和实验
- 技术资料
- 形态：
液态/粉状
- 保存条件：
-20℃保存
- 克隆性：
多克隆
- 标记物：
见说明书
- 适应物种：
人，大鼠，小鼠，兔
- 宿主：
Goat，Rabbit，Mouse
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 靶点：
来电咨询
- GABAA Receptor α1 Subunit N-Terminus Polyclonal Antibody详细信息：
-
Description A Receptor α1 Subunit N-Terminus Polyclonal Antibody - NEUROSCIENCE" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> Polyclonal Antibody against GABAA Receptor α1 Subunit N-Terminus Form 
Affinity Purified Antibody in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA and 50% glycerol. Host Rabbit Species Reactivity Rat. Mouse and rat have 100% amino acid sequence identity with the antigen used to raise the antibody. Specificity A Receptor α1 Subunit N-Terminus Polyclonal Antibody - NEUROSCIENCE" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> GABAA Receptor α1 Subunit N-Terminus Polyclonal AntibodyGamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA-Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α and β subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a γ subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α subunits of the receptor. Lastly, phosphorylation of β subunits of the receptor has been shown to modulate GABAA-R function.
This antibody was raised against an N-terminal peptide of the rat GABAA receptor α1 subunit coupled to KLH. It was subsequently purified by chromatography on the N-terminus peptide column. PRB-563P is specific for the 51k band of GABAA α1-subunit in rat brain membrane fractions.Uses A Receptor α1 Subunit N-Terminus Polyclonal Antibody - NEUROSCIENCE" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> This antibody is effective in immunoblotting; other applications not yet determined. Suggested Working Dilution A Receptor α1 Subunit N-Terminus Polyclonal Antibody - NEUROSCIENCE" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> GABAA Receptor α1 Subunit N-Terminus Polyclonal AntibodyThe optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior written approval. - Western blot: 1:500-1:1,000*
- Dot blot: 1:500-1:1,000
Notes A Receptor α1 Subunit N-Terminus Polyclonal Antibody - NEUROSCIENCE" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> *Predicted MW = 51kD Storage A Receptor α1 Subunit N-Terminus Polyclonal Antibody - NEUROSCIENCE" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Long term storage should be at -80°C. This shelf-life of this product is approximately 1 year.
References Kittler JT, McAinsh K, Moss SJ. Mechanisms of GABA A receptor assembly and trafficking - Implications for the modulation of inhibitory neurotransmission. Mol. Neurobiol. 26:2251 - 268, 2002.
Whiting PJ, McKernan RM, Wafford KA. Structure and pharmacology of vertebrate, GABAA receptor subtypes. In: International Review of Neurobiology (Bradley RJ, Harris RA, eds.), pp 95, San Diego: Academic Press, 1995.
Zezula J, Fuchs K, Sieghart W. Separation of alpha-1, alpha-2 and alpha-3 subunits of the GABAA-benzodiazepine receptor complex by immunoaffinity chromatography.Brain Res. 563:325 -328, 1991.
Olsen RW, Tobin AJ. Molecular biology of GABAA receptors. FASEB 4:1469 - 1480, 1990.
Pritchett DB, Sontheimer H, Shivers BD, Yner S, Kettenman H, Schofield PR, Seeburg PH. Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology.Nature (London) 338:582-585, 1989.
Blair LAC, Levitan ES, Marshall J, Dionne VE, Barnard EA. Single subunits of the GABAA receptor form ion channels with properties of the native receptor. Science 242:577-579, 1988.Warranty/Conditions A Receptor α1 Subunit N-Terminus Polyclonal Antibody - NEUROSCIENCE" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> Covance products may not be resold or modified for resale without prior written approval. - GABAA Receptor α1 Subunit N-Terminus Polyclonal Antibody
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xy-1210xy BRCA2(Breast cancer susceptbility gene 2)乳腺癌易感基因2抗原
xy-0182xy PTP-1B (Protein-tyrosine phosphatase, non-receptor )蛋白酪氨酸磷酸酶-1B（抗原）
xy-0251xy RAR-Alpha (Retinoic acid -R-Alpha)维甲酸受体-α 多肽
xy-0319xy glycoprotein (E1 glycoprotein) [Rubella virus]风疹病毒糖蛋白多肽片段
xy-0121xy SAP-1 (Synapse associated protein-I) peptide突触相关蛋白-1（多肽抗原）
xy-0130xy SARS S-protein(抗原)
xy-0132xy SARS putative orflab polyprotein (SARS coronavirus CUHK-W1)(抗原)
xy-1954xy BSEP peptide胆汁酸盐输出泵蛋白抗原
xy-0088xy Secretin分泌素（抗原）
xy-0089xy Secretin receptor分泌素受体（抗原）
xy-0113xy Socs 1 (suppressor of cytokine signaling 1)细胞激酶信号-1抑制剂（抗原）
xy-0259xy SM-MHC(Cardiac myosin heavy chain)心肌肌凝蛋白多肽
xy-0009xy Alpha-Synuclein核突触蛋白（抗原）
xy-0012xy Alpha-Synuclein核突触蛋白（抗原）
xy-1239xy CA15-3 peptide乳腺癌相关抗原抗原
xy-0064xy Substance P Receptor (Neurokinin receptor1;Tachykinin receptor1)P物质受体（抗原）
xy-2082xy p-Caldesmon(phosphor-Ser789)磷酸化钙介质素抗原
xy-0123xy NK-2R peptide神经激肽A受体（多肽抗原）
xy-1099xy Calpain 1钙蛋白酶（多肽）
xy-0277xy Tanis/SELS (Selenoprotein S)又称SELS炎症负调控因子蛋白（抗原）
xy-0157xy Tau protein微管相关蛋白（抗原）
xy-0233xy Telomerase (TE)端粒酶（催化亚单位）（多肽抗原）
xy-0066xy TGF-Alpha (Ttansforming Growth Factor –Alpha)转移生长因子–α（抗原）
xy-0564xy CaMK2a(calcium/calmodulin-dependent protein kinase II alpha)钙/钙调素依赖蛋白激酶2α抗原
xy-1809xy Camk1g(Calcium/calmodulin dependent protein kinase IG)钙/钙调蛋白依赖蛋白激酶IG抗原
xy-0103xy TGF- Beta1 (Ttansforming Growth Factor – Beta1)转移生长因子–β1（抗原）
xy-0541xy CaMK2b(calcium/calmodulin-dependent protein kinase II beita)钙/钙调素依赖蛋白激酶2b抗原
xy-1306xy CAP1/Park7/DJ-1Park7/DJ-1/CAP1抗原
xy-1616xy CAP2(Adenylyl cyclase-associated protein 2)环化酶相关蛋白CAP-2抗原
xy-0100xy TGF beta 2 Propeptide转移生长因子–β2前体肽
xy-0099xy TGF- Beta3 (Ttansforming Growth Factor – Beta3)转移生长因子–β3（抗原）
xy-0117xy TGF- Beta R2 peptide转移生长因子β受体2（多肽抗原）
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GABAA Receptor α1 Subunit N-Terminus Polyclonal Antibody
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