- 询价
- R&D
- ZK-0101536
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
1 年钻石会员
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- GABAA Receptor α1 Subunit N-Terminus Polyclonal Antibody详细信息：
-
Description Polyclonal Antibody against GABAA Receptor α1 Subunit N-Terminus Form Affinity Purified Antibody in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA and 50% glycerol. Host Rabbit Species Reactivity Rat. Mouse and rat have 100% amino acid sequence identity with the antigen used to raise the antibody. Specificity GABAA Receptor α1 Subunit N-Terminus Polyclonal AntibodyGamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA-Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α and β subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a γ subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α subunits of the receptor. Lastly, phosphorylation of β subunits of the receptor has been shown to modulate GABAA-R function.
This antibody was raised against an N-terminal peptide of the rat GABAA receptor α1 subunit coupled to KLH. It was subsequently purified by chromatography on the N-terminus peptide column. PRB-563P is specific for the 51k band of GABAA α1-subunit in rat brain membrane fractions.Uses This antibody is effective in immunoblotting; other applications not yet determined. Suggested Working Dilution GABAA Receptor α1 Subunit N-Terminus Polyclonal AntibodyThe optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior written approval. - Western blot: 1:500-1:1,000*
- Dot blot: 1:500-1:1,000
Notes *Predicted MW = 51kD Storage Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Long term storage should be at -80°C. This shelf-life of this product is approximately 1 year.
References Kittler JT, McAinsh K, Moss SJ. Mechanisms of GABA A receptor assembly and trafficking - Implications for the modulation of inhibitory neurotransmission. Mol. Neurobiol. 26:2251 - 268, 2002.
Whiting PJ, McKernan RM, Wafford KA. Structure and pharmacology of vertebrate, GABAA receptor subtypes. In: International Review of Neurobiology (Bradley RJ, Harris RA, eds.), pp 95, San Diego: Academic Press, 1995.
Zezula J, Fuchs K, Sieghart W. Separation of alpha-1, alpha-2 and alpha-3 subunits of the GABAA-benzodiazepine receptor complex by immunoaffinity chromatography.Brain Res. 563:325 -328, 1991.
Olsen RW, Tobin AJ. Molecular biology of GABAA receptors. FASEB 4:1469 - 1480, 1990.
Pritchett DB, Sontheimer H, Shivers BD, Yner S, Kettenman H, Schofield PR, Seeburg PH. Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology.Nature (London) 338:582-585, 1989.
Blair LAC, Levitan ES, Marshall J, Dionne VE, Barnard EA. Single subunits of the GABAA receptor form ion channels with properties of the native receptor. Science 242:577-579, 1988.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - GABAA Receptor α1 Subunit N-Terminus Polyclonal Antibody
- zk-0179zk PSD-95 突触后密度蛋白95（抗原）
zk-1210zk BRCA2(Breast cancer susceptbility gene 2)乳腺癌易感基因2抗原
zk-0182zk PTP-1B (Protein-tyrosine phosphatase, non-receptor )蛋白酪氨酸磷酸酶-1B（抗原）
zk-0251zk RAR-Alpha (Retinoic acid -R-Alpha)维甲酸受体-α 多肽
zk-0319zk glycoprotein (E1 glycoprotein) [Rubella virus]风疹病毒糖蛋白多肽片段
zk-0121zk SAP-1 (Synapse associated protein-I) peptide突触相关蛋白-1（多肽抗原）
zk-0130zk SARS S-protein(抗原)
zk-0132zk SARS putative orflab polyprotein (SARS coronavirus CUHK-W1)(抗原)
zk-1954zk BSEP peptide胆汁酸盐输出泵蛋白抗原
zk-0088zk Secretin分泌素（抗原）
zk-0089zk Secretin receptor分泌素受体（抗原）
zk-0113zk Socs 1 (suppressor of cytokine signaling 1)细胞激酶信号-1抑制剂（抗原）
zk-0259zk SM-MHC(Cardiac myosin heavy chain)心肌肌凝蛋白多肽
zk-0009zk Alpha-Synuclein核突触蛋白（抗原）
zk-0012zk Alpha-Synuclein核突触蛋白（抗原）
zk-1239zk CA15-3 peptide乳腺癌相关抗原抗原
zk-0064zk Substance P Receptor (Neurokinin receptor1;Tachykinin receptor1)P物质受体（抗原）
zk-2082zk p-Caldesmon(phosphor-Ser789)磷酸化钙介质素抗原
zk-0123zk NK-2R peptide神经激肽A受体（多肽抗原）
zk-1099zk Calpain 1钙蛋白酶（多肽）
zk-0277zk Tanis/SELS (Selenoprotein S)又称SELS炎症负调控因子蛋白（抗原）
zk-0157zk Tau protein微管相关蛋白（抗原）
zk-0233zk Telomerase (TE)端粒酶（催化亚单位）（多肽抗原）
zk-0066zk TGF-Alpha (Ttansforming Growth Factor –Alpha)转移生长因子–α（抗原）
zk-0564zk CaMK2a(calcium/calmodulin-dependent protein kinase II alpha)钙/钙调素依赖蛋白激酶2α抗原
zk-1809zk Camk1g(Calcium/calmodulin dependent protein kinase IG)钙/钙调蛋白依赖蛋白激酶IG抗原
zk-0103zk TGF- Beta1 (Ttansforming Growth Factor – Beta1)转移生长因子–β1（抗原）
zk-0541zk CaMK2b(calcium/calmodulin-dependent protein kinase II beita)钙/钙调素依赖蛋白激酶2b抗原
zk-1306zk CAP1/Park7/DJ-1Park7/DJ-1/CAP1抗原
zk-1616zk CAP2(Adenylyl cyclase-associated protein 2)环化酶相关蛋白CAP-2抗原
zk-0100zk TGF beta 2 Propeptide转移生长因子–β2前体肽
zk-0099zk TGF- Beta3 (Ttansforming Growth Factor – Beta3)转移生长因子–β3（抗原）
zk-0117zk TGF- Beta R2 peptide转移生长因子β受体2（多肽抗原）
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
GABAA Receptor α1 Subunit N-Terminus Polyclonal Antibody
询价
