Stemolecule™ PD0325901

Stemolecule™ PD0325901详细信息：
Product Overview

PD0325901是具有生物效应的小分子，作用于MEK，具有潜在的抗肿瘤药性。PD0325901是MEK抑制剂CI-1040的衍生物，选择性的与之结合并抑制MEK，抑制MAPK/ERK的激活和磷酸化，并且抑制肿瘤细胞的增殖。
PD0325901 is an orally bioavailable, synthetic organic molecule targeting mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. PD0325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation1,2.

Stemolecule™ PD0325901Product Specifications

Chemical Formula C16H14F3IN2O4
Structure [structure graphics]
Molecular Weight 482.19
Purity >98% by HPLC analysis
Formulation Pale purple solid
Solubility Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 415 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
Storage 4°C protected from light. Following reconstitution, store aliquots at -20°C
Stability Stock solutions stable at -20°C for 6 months
Quality Control The purity of PD0325901 was determined by HPLC analysis. The accurate mass and structure of PD0325901 was determined by mass spectrometry and NMR, respectively. Cellular toxicity of PD0325901 was tested by using HeLa and HEK293 cells.
Stemolecule™ PD0325901
xy11612 大鼠肝星形细胞,CFSC-3H & 5H细胞
xy11613 大鼠肝星形细胞,CFSC-2G细胞
xy11614 大鼠肝细胞瘤细胞,H-4-Ⅱ-E细胞
xy11615 大鼠肝细胞瘤 H4-II-E-C3细胞
xy11616 大鼠肝细胞,IAR20细胞
xy11617 大鼠肝细胞,BRL细胞
xy11618 大鼠肝细胞,BRL大鼠Buffalo细胞
xy11619 大鼠肝细胞,BRL 3A细胞
xy11620 大鼠肝上皮样干细胞,WB-F344细胞
xy11621 大鼠肝癌细胞（乳腺癌细胞接种到肝脏成瘤） Walker-256细胞
xy11622 大鼠肝癌细胞（wistar 大鼠） CBRH7919细胞
xy11623 大鼠肝癌细胞,Walker-256细胞,
xy11624 大鼠肝癌细胞,RH-35细胞
xy11625 大鼠肝癌细胞,H4-II-E-C3细胞
xy11626 大鼠肝癌细胞,H4-ⅡE细胞
xy11627 大鼠肝癌细胞,CRL-1548细胞
xy11628 大鼠肝癌细胞,CBRH-7919细胞
xy11629 大鼠肝癌 R15细胞,
xy11630 大鼠肺上皮Ⅱ型细胞,RLE-6TN细胞
xy11631 大鼠肺泡巨噬细胞,NR8383细胞
xy11632 大鼠埀体瘤细胞,GH3细胞
xy11633 大鼠垂体细胞,RPC细胞
xy11634 大鼠垂体瘤细胞,MMQ细胞
xy11635 大鼠垂体瘤细胞,GH3细胞
xy11636 大鼠成纤维细胞,208F细胞
xy11637 大鼠成肌细胞(分化）\L6细胞
xy11638 大鼠成肌细胞,L6细胞,
xy11639 大鼠成骨细胞,ROS1728细胞
xy11640 大鼠鼻咽癌细胞,FAT细胞
xy11641 大丽花轮枝孢
xy11642 大黄鱼肾细胞,PCK细胞
xy11643 大黄鱼EPC细胞,EPC细胞
xy11644 大肠杆菌
xy11645 大肠埃希氏菌O157：H7
xy11646 大肠埃希氏菌(大肠杆菌)
xy11647 大肠埃希氏菌
xy11648 大肠埃氏菌
xy11649 大孢绿僵菌=金龟子绿僵菌大孢变种
xy11650 痤疮丙酸杆菌
xy11651 脆弱拟杆菌
xy11652 刺孢吸水链霉菌昆明变种
Stemolecule™ PD0325901xy11653 刺孢吸水链霉菌
xy11654 创伤弧菌
xy11655 串珠镰刀菌