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- 详细信息
- 技术资料
- 保存条件：
4℃保存
- 保质期：
6个月
- 英文名：
Stemolecule PD0325901
- 库存：
1
- 供应商：
上海信裕
- Stemolecule PD0325901保存于运输说明：
- 4°C protected from light. Following reconstitution, store aliquots at -20°C
- 详细信息：
-
Stemolecule™ PD0325901
PD0325901是具有生物效应的小分子，作用于MEK，具有潜在的抗肿瘤药性。PD0325901是MEK抑制剂CI-1040的衍生物，选择性的与之结合并抑制MEK，抑制MAPK/ERK的激活和磷酸化，并且抑制肿瘤细胞的增殖。
PD0325901 is an orally bioavailable, synthetic organic molecule targeting mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. PD0325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation1,2. View Poster
Stemolecule PD0325901产品参数
Chemical Formula C16H14F3IN2O4 Structure Molecular Weight 482.19 Purity >98% by HPLC analysis Formulation Pale purple solid Solubility Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 415 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%. Storage Stemolecule PD0325901 4°C protected from light. Following reconstitution, store aliquots at -20°C Stability Stock solutions stable at -20°C for 6 months Quality Control The purity of PD0325901 was determined by HPLC analysis. The accurate mass and structure of PD0325901 was determined by mass spectrometry and NMR, respectively. Cellular toxicity of PD0325901 was tested by using HeLa and HEK293 cells. References - Bain, J. et al., Biochem. J. 408:297-315 (2007).
- Sebolt-Leopold, J. S. ∓ Herrera, R. Nature Rev. Cancer 4:937-947 (2004).
- Tongxiang Lin, Rajesh Ambasudhan, Xu Yuan, Wenlin Li, Simon Hilcove, Ramzey Abujarour, Xiangyi Lin, Heung Sik Hahm, Ergeng Hao, Alberto Hayek & Sheng Ding. (2009) A chemical platform for improved induction of human iPSCs. Nat Meth 1393.
- Stemolecule PD0325901
- xy-1747xy DRD5 receptor(dopamine D5 receptor)多巴胺受体-D5抗原
xy-0596xy DBH (Dopamine- Beta-Hydroxylase)多巴胺β羟化酶（抗原）
xy-0592xy DCC (Deleted in colorectal cancer gene)结直肠癌缺失基因抗原
xy-1269xy DCX(Doublecortin)双皮质素抗原
xy-2599xy DDB2(DNA damage-binding protein 2)损伤DNA结合蛋白2抗原
xy-1163xy Defensin Beta1防御素β1抗原
xy-2165xy Defensin Beta1(human)防御素β1抗原(人)
xy-1295xy Defensin Beta2/beta-defensin 2/BD-2(mouse)防御素β2抗原（小鼠）
xy-1296xy Defensin Beta2/beta-defensin 2/BD-2(rat)防御素β2抗原（大鼠）
xy-1687xy DAPK1(Death associated protein kinase 1)凋亡相关蛋白激酶1抗原
xy-2197xy DHAV(duck hepatitis A virus)鸭甲型肝炎A病毒抗原
xy-1026xy Des(Desmin)结蛋白抗原
xy-2162xy DKK1(Dickkopf 1)抑癌蛋白DKK1抗原
xy-0595xy DMBT1 (Deleted in malignant brain tumor 1)DMBT1抑癌基因抗原
xy-1359xy DNA-PKcs peptideDNA依赖蛋白激酶催化亚基多肽抗原
xy-0597xy DPPA2 (developmental pluripotency associated gene2)多能发育相关基因2抗原
xy-0591xy DR4/APO2/TRAILR1 (Death receptor 4)死亡受体4抗原
xy-1696xy DR5/TNFRSF10B/CD262 (Death receptor 5)肿瘤细胞调亡素/死亡受体5抗原
xy-1748xy DP-I/DSP(desmoplakin I )桥粒斑蛋白1抗原
xy-0598xy DVL1 (dishevelled 1)蓬乱蛋白1
xy-0574xy Dynamin 2(Anti-Human Dynamin-2 )鸟苷三磷酸酶－发动蛋白2抗体
xy-0831xy Nadrin peptide发育调节蛋白多肽抗原
xy-0599xy E2F1转录因子E2F-1
xy-1001xy E2F2转录因子E2F-2抗原
xy-1399xy E2F4转录因子E2F-4抗原
xy-1750xy E2F6转录因子E2F-6抗原
xy-2071xy E2 tagE2 tag多肽抗原
xy-1752xy EAAT3(Excitatory amino acid transporters 3)胶质细胞谷氨酸运载蛋白3抗原
xy-0820xy EBNA-3 (Epstein barr nuclear antigens 3)EB病毒编码核蛋白-3
xy-1190xy ECE1(Endothelin Converting Enzyme 1)内皮素转化酶1抗原
xy-1753xy ECE2(Endothelin Converting Enzyme 2)内皮素转化酶2抗原
xy-1754xy ECP(eosinophil cationic protein)mouse rat嗜酸性粒细胞阳离子蛋白抗原
xy-1149xy ED-1 (Ectodermal Dysplasia 1)外胚层发育不良抗原
xy-1755xy EGFL7(EGF-like domain containing protein 7)类表皮生长因子域7抗原
xy-1076xy Egr-1(Early growth response 1)早期反应基因-1/应急反应生长基因1抗原
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Stemolecule PD0325901
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