Stemolecule™ PD173074

Stemolecule™ PD173074详细信息：
Product Overview



Stemolecule™ PD173074 is a potent, cell-permeable and ATP-competitive inhibitor of fibroblast growth factor (FGF) receptor1. Inhibition of the FGF signaling pathway leads to self-renewal of stem cells in many systems. Treatment of FGF2-expressing human multipotent adipose-derived stem cells with PD173074 significantly decreased their clonogenicity and differentiation potential2. Also, differentiation of mouse embryonic stem (ES) cells requires auto-inductive stimulation of the mitogen-activated protein kinase pathway by FGF43,4 including autocrine FGF45.

Stemolecule™ PD173074Product Specifications

Chemical Formula C28H41N7O3
Alternate Name 1-t-Butyl-3-(6-(3,5- dimethoxyphenyl)-2- (4-diethylaminobutylamino)- pyrido[2,3-d]pyrimidin- 7-yl)urea
Structure structure
Molecular Weight 523.7
CAS Number 219580-11-7
Purity >98.8% by HPLC analysis
Formulation Yellow solid
Solubility Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 382 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
Storage 4°C protected from light. Following reconstitution, store aliquots at -20°C
Stability Stock solutions stable at -20°C for 6 months
Quality Control The purity of PD173074 was determined by HPLC analysis. The accurate mass and structure of PD173074 was determined by mass spectrometry and NMR, respectively. Cellular toxicity of PD173074 was tested by using HeLa and HEK293 cells.
Stemolecule™ PD173074
xy11569 大鼠胰岛素细胞,INS-1细胞
xy11570 大鼠血管平滑肌细胞,USMC细胞
xy11571 大鼠雪旺细胞,RSC96细胞,
xy11572 大鼠胸主动脉平滑肌细胞，ATCC：A10 VSMC细胞
xy11573 大鼠胸大动脉平滑肌细胞,A7r5细胞,
xy11574 大鼠心肌细胞,H9c2(2-1)细胞,
xy11575 大鼠小肠隐窝上皮细胞,IEC-6细胞
xy11576 大鼠嗜碱性细胞白血病细胞,RBL-2H3细胞,
xy11577 大鼠嗜碱性粒细胞性白血病细胞,RBL-1细胞
xy11578 大鼠嗜铬细胞瘤 PC-12细胞,
xy11579 大鼠肾小球系膜细胞EC (HBZY－1) HBZY－1细胞
xy11580 大鼠肾小球系膜细胞,HBZY-1细胞,
xy11581 大鼠肾小管上皮细胞，ATCC：CRL-6509 NRK细胞
xy11582 大鼠肾细胞,NRK细胞
xy11583 大鼠肾细胞,NRK-52E细胞
xy11584 大鼠肾上腺嗜铬细胞瘤细胞(未分化) PC-12细胞
xy11585 大鼠肾上腺嗜铬细胞瘤细胞,PC12细胞
xy11586 大鼠肾成纤微细胞,NRK-49F细胞
xy11587 大鼠神经胶质瘤细胞,C6细胞
xy11588 大鼠乳腺腺癌细胞系 MADB106细胞
xy11589 大鼠乳腺癌细胞,SHZ-88细胞,
xy11590 大鼠乳腺癌细胞,MADB-106细胞
xy11591 大鼠肉瘤细胞,WK256细胞
xy11592 大鼠气管上皮细胞,RTE细胞
xy11593 大鼠皮层神经元细胞,RN-c细胞
xy11594 大鼠脑膜细胞,RMC细胞
xy11595 大鼠脑胶质瘤细胞,F98-RFP-puro细胞
xy11596 大鼠脑胶质瘤细胞,C6细胞,
xy11597 大鼠脑胶质瘤细胞,C6-RFP细胞
xy11598 大鼠脑胶质瘤细胞,C6-EGFP-puro细胞
xy11599 大鼠脑间质细胞,DI TNC1细胞
xy11600 大鼠卵巢癌细胞株 NUTU-19细胞
xy11601 大鼠巨噬细胞,MC细胞
xy11602 大鼠胶质瘤细胞,C6细胞
xy11603 大鼠回肠细胞,IEC-18细胞,
xy11604 大鼠滑膜细胞
xy11605 大鼠骨髓瘤细胞IR983F细胞
xy11606 大鼠骨髓瘤细胞,Y3-Ag1.2.3细胞
xy11607 大鼠骨肉瘤细胞,UMR-106细胞,
xy11608 大鼠骨肉瘤 VMR106细胞
xy11609 大鼠骨骼肌成肌细胞,L6细胞
Stemolecule™ PD173074xy11610 大鼠肝星形细胞,HSC-T6细胞,
xy11611 大鼠肝星形细胞,CFSC-8B细胞